The invention provides a multi-channel respiratory physiological signal wireless monitoring system, which comprises a sensor, a data acquisition sending terminal, a data receiving terminal and a PC and the sensor, the data acquisition sending terminal, the data receiving terminal and the PC are connected in sequence. The sensor is arranged on a diaphragm signal detection tube or a multi-functional respiratory signal detection tube of a patient; the acquisition sending terminal comprises a power supply module and a multi-channel signal amplifier module, an AD conversion module, an MCU acquisition and a transmission control module and a wireless transmission module, the multi-channel signal amplifier module, the AD conversion module, the MCU acquisition and the transmission control module and the wireless transmission module are connected in sequence. The power supply module is respectively connected with the multi-channel signal amplifier module, the AD conversion module, the MCU acquisition and transmission control module and the wireless transmission module. The receiving terminal comprises a wireless receiving module and an MCU receiving control module which are mutually connected and the MCU receiving control module is connected with the PC. The patient carrying the acquisition sending terminal can transmit 5-channel diaphragm myoelectric signal or cardiac electric signal, 3-channel respiratory pressure and flow signal to a remote monitoring center by the way of wireless, thus achieving the real-time display, storage, analysis and treatment of multi-channel signal.