Drugs to treat radiation pneumonitis

A technology of traditional Chinese medicine and composition, applied in the field of medicines for the treatment of radiation pneumonia, can solve the problems of inability to effectively control the development of lung injury, large adverse reactions, dysbacteriosis, etc., and achieve the effects of improving quality of life, significant curative effect, and small side effects

Inactive Publication Date: 2016-11-30
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is still no safe and effective treatment for radiation pneumonitis at home and abroad. Clinically, adrenocorticosteroids combined with antibiotics supplemented by oxygen inhalation, asthma relief, cough relief and other symptomatic support treatments are used, but the adverse reactions are large, and it is easy to cause superinfection. Bacterial imbalance, immunosuppression, etc., and despite the use of glucocorticoids, a considerable number of patients cannot effectively control the development of lung injury, and eventually progress to pulmonary fibrosis

Method used

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preparation example Construction

[0055]The present invention also provides a preparation method of the above-mentioned Chinese medicine composition, when the Chinese medicine composition is prepared into an oral liquid, specifically:

[0056] In the first step, the components are mixed in proportion, placed in an ultrafine pulverizer and pulverized for 20 to 40 minutes, and the pulverized mixture is dissolved in ethanol with an alcohol concentration of 80% to 90%, and extracted twice by reflux ~4 times, filter, combine the filtrates, concentrate under reduced pressure to remove ethanol, and obtain a dry paste, wherein the amount of ethanol added is 2 to 4 times the quality of the mixture in the first step, followed by drying and pulverizing with a superfine pulverizer for 20 Minutes to 40 minutes, dissolve the pulverized powder in water 3 to 5 times its mass, filter, add hydrochloric acid with a concentration of 10% to adjust the pH to 3 to 4, stand still for 2 to 4 hours, filter, and the filtrate Extract wit...

Embodiment 1

[0063] The preparation of embodiment 1 oral liquid 1

[0064] Rehmannia glutinosa 25g, Radix Asparagus 35g, Paeoniae Alba 30g, Campanulaceae 20g, Cordyceps sinensis 35g, Fritillaria sichuanensis 25g, sarcocarpus 20g, Eclipta chinensis 25g, Cornus officinalis 35g, loquat leaves 20g, Shouwu vine 30g, Scrophularia scrophulariae 25g, Mix 35g honeysuckle, 30g baicalensis, 20g licorice, 35g sealwort, 45g American ginseng, 25g three-lens grass, 30g native ginseng, 25g celery, 20g golden buckwheat, 15g wintersweet and 15g peacock tail, mix them in a superfine pulverizer In 30 minutes, the pulverized mixture was dissolved in 1.8 kg of ethanol with an alcohol concentration of 90%, extracted 3 times by reflux, filtered, combined filtrates, concentrated under reduced pressure to remove ethanol, and obtained a dry paste, which was subsequently dried and used Pulverize with a pulverizer for 30 minutes, dissolve the pulverized powder in water three times its mass, filter, add 10% hydrochlori...

Embodiment 2

[0065] The preparation of embodiment 2 oral liquid 2

[0066] Rehmannia glutinosa 23g, Radix Asparagus 33g, Paeoniae Alba 28g, Campanulaceae 18g, Cordyceps sinensis 33g, Fritillaria sichuanensis 23g, sarcocarpus 18g, Eclipta chinensis 23g, Cornus officinalis 33g, loquat leaves 18g, Shouwu vine 28g, Scrophularia scrophulariae 23g, Mix 33g honeysuckle, 28g baicalensis, 18g licorice, 33g sealwort, 43g American ginseng, 23g three-lens grass, 28g native ginseng, 23g duck celery, 18g golden buckwheat, 13g wintersweet and 13g peacock tail, mix them in a superfine pulverizer For 30 minutes, the pulverized mixture was dissolved in 1.5kg of ethanol with an alcohol concentration of 90%, extracted 3 times by reflux, filtered, combined filtrates, concentrated under reduced pressure to remove ethanol, and obtained a dry paste, which was subsequently dried and used Pulverize with a pulverizer for 30 minutes, dissolve the pulverized powder in water three times its mass, filter, add 10% hydroc...

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Abstract

The invention provides a traditional Chinese medicine composition for treating radiation pneumonitis. The raw materials of the traditional Chinese medicine composition include Rehmannia glutinosa, Radix Asparagus, Radix Paeoniae Alba, Platycodon grandiflorum, Cordyceps sinensis, Fritillaria sichuanensis, sarcophagus, Eclipta chinensis, Dogwood, loquat leaves, Shouwu vine, scrophulariaceae, honeysuckle, scutellaria baicalensis, licorice, sealwort, American ginseng, three-lens grass, native ginseng, duck celery, golden buckwheat, wintersweet and peacock tail. It not only has the definite effect of anti-radiation pneumonitis, but also can strengthen the whole body and enhance immunity, thus reducing and delaying the recurrence and metastasis of tumors. , significant curative effect, less side effects, and can improve the quality of life of patients, it is worthy of clinical promotion and use.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a medicine for treating radiation pneumonitis. Background technique [0002] Worldwide, the incidence and mortality of lung cancer are increasing year by year. According to statistics, there are 1.2 million new cases every year in the world, accounting for 12.1% of the total incidence of cancer. Among cancer deaths, lung cancer accounts for 16.9%, with 918,000 deaths per year. Epidemiologists predict that lung cancer has become one of the most common diseases in the 21st century. The mortality rate of lung cancer is very high, and it seriously threatens people's health and life. Because 70% of the patients are already in the middle and late stages when they are diagnosed with the disease, the best time for surgery has been missed. Therefore, comprehensive treatment based on radiotherapy should be adopted. However, the lung is a radiosensitive organ, and it ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8969A61K9/08A61K9/12A61P11/00
Inventor 任锦于丹杨俊玲尹金植闫冰迪高蓉曲丹华
Owner JILIN UNIV
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