Astragalus polysaccharide sustained release microsphere for treating radiation pneumonitis and preparation method of astragalus polysaccharide sustained release microsphere

Abstract

The invention discloses an astragalus polysaccharide sustained release microsphere for treating radiation pneumonitis. The astragalus polysaccharide sustained release microsphere comprises the following components in parts by weight: 1 part of astragalus polysaccharide and 3-7 parts of chitosan, wherein the degree of polymerization of chitosan is 30CPS, 50CPS and 130 CPS. The invention simultaneously discloses a preparation method of the astragalus polysaccharide sustained release microsphere. The astragalus polysaccharide sustained release microsphere prepared by virtue of the preparation method has an ideal targeting effect, can slowly release after being administrated, is long in action time and is capable of increasing the concentration of astragalus polysaccharide in target organs, and the high local blood concentration is avoided; the astragalus polysaccharide sustained release microsphere is safe and environmentally friendly and has high treatment effect to radiation pneumonitis and little side effect; the operation is simple and convenient, a process is stable, and industrial production is easily realized; the astragalus polysaccharide sustained release microsphere is high in encapsulation efficiency and drug loading capacity; the skin of a patient is smooth and fine after the administration.

Description

technical field

[0001] The invention relates to a sustained-release microsphere, in particular to an astragalus polysaccharide sustained-release microsphere for treating radiation pneumonitis and a preparation method thereof, belonging to the field of biomedicine. Background technique

[0002] Radiation therapy is one of the effective methods for treating malignant tumors, but radiation pneumonitis often occurs 1 to 6 months after irradiation. The incidence rate of radiation pneumonitis reported in China is 8.25-29.60%, and it is 19.0-37.2% in foreign reports. Radiation pneumonitis is a common complication of lung cancer, breast cancer, esophageal cancer, radiotherapy for head and neck tumors, bone marrow transplantation preconditioning, nuclear radiation events, and nuclear weapon injuries. In the early stages of radiation pneumonitis, patients may experience varying degrees of blood toxicity, as well as symptoms such as fatigue, nausea, diarrhea, and hair loss; in the late...

Images