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Astragalus polysaccharide sustained release microsphere for treating radiation pneumonitis and preparation method of astragalus polysaccharide sustained release microsphere

A technology of radiation pneumonitis and astragalus polysaccharides, which is applied in the field of biomedicine, can solve the problems of no tissue and organ targeting, failure to reach the action time, and high local blood drug concentration, and achieve a good mental state, prolonged absorption, and rich blood flow. Effect

Active Publication Date: 2015-05-06
WEIFANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the astragalus polysaccharide raw material has the following shortcomings: no tissue and organ targeting; local blood drug concentration will be too high immediately after administration; the action time in the body is short or cannot reach the expected action time

Method used

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  • Astragalus polysaccharide sustained release microsphere for treating radiation pneumonitis and preparation method of astragalus polysaccharide sustained release microsphere
  • Astragalus polysaccharide sustained release microsphere for treating radiation pneumonitis and preparation method of astragalus polysaccharide sustained release microsphere
  • Astragalus polysaccharide sustained release microsphere for treating radiation pneumonitis and preparation method of astragalus polysaccharide sustained release microsphere

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Comparison scheme
Effect test

Embodiment 1

[0035] A preparation method for the astragalus polysaccharide slow-release microspheres for the treatment of radiation pneumonitis, comprising the following steps:

[0036] (1) Preparation of raw material solution

[0037] Accurately weigh 3 parts of chitosan with a degree of polymerization of 30CPS and 1 part of astragalus polysaccharide, which are vacuum-dried to constant weight at room temperature, dissolve in 1000 mL of 0.5% acetic acid solution, and mix;

[0038] (2) Filtration, spray drying

[0039] Filter the mixed solution obtained in the above step (1) through a 0.45 μm microporous membrane to obtain the filtrate. The obtained subsequent filtrate is introduced into the double-flow spiral nozzle of the Büchi 290 small spray dryer through a peristaltic pump, and the inlet temperature is controlled at 120°C. The feed rate is 3 mL / min;

[0040] (3) Preparation of microsphere powder

[0041] The astragalus polysaccharide sustained-release microsphere powder was prepared...

Embodiment 2

[0044] A preparation method for the astragalus polysaccharide slow-release microspheres for the treatment of radiation pneumonitis, comprising the following steps:

[0045] (1) Preparation of raw material solution

[0046]Accurately weigh 5 parts of chitosan with a degree of polymerization of 50CPS and 1 part of astragalus polysaccharide, which were vacuum-dried to constant weight at room temperature, dissolved in 1000 mL of 0.5% acetic acid solution, and mixed;

[0047] (2) Filtration, spray drying

[0048] Filter the mixed solution obtained in the above step (1) through a 0.45 μm microporous membrane to obtain the filtrate. The obtained subsequent filtrate is introduced into the double-flow spiral nozzle of the Büchi 290 small spray dryer through a peristaltic pump, and the inlet temperature is controlled at 120 ° C. The feed rate is 5 mL / min;

[0049] (3) Preparation of microsphere powder

[0050] The astragalus polysaccharide sustained-release microsphere powder was pre...

Embodiment 3

[0053] A preparation method for the astragalus polysaccharide slow-release microspheres for the treatment of radiation pneumonitis, comprising the following steps:

[0054] (1) Preparation of raw material solution

[0055] Accurately weigh 5 parts of chitosan with a degree of polymerization of 130CPS, 2 parts of chitosan at 50CPS, and 1 part of astragalus polysaccharide that were vacuum-dried to constant weight at room temperature, dissolved in 1000 mL of 0.5% acetic acid solution, and mixed;

[0056] (2) Filtration, spray drying

[0057] Filter the mixed solution obtained in the above step (1) through a 0.45 μm microporous membrane to obtain the filtrate. The obtained subsequent filtrate is introduced into the double-flow spiral nozzle of the Büchi 290 small spray dryer through a peristaltic pump, and the inlet temperature is controlled at 120°C. The feed rate is 7 mL / min;

[0058] (3) Preparation of microsphere powder

[0059] The astragalus polysaccharide sustained-relea...

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Abstract

The invention discloses an astragalus polysaccharide sustained release microsphere for treating radiation pneumonitis. The astragalus polysaccharide sustained release microsphere comprises the following components in parts by weight: 1 part of astragalus polysaccharide and 3-7 parts of chitosan, wherein the degree of polymerization of chitosan is 30CPS, 50CPS and 130 CPS. The invention simultaneously discloses a preparation method of the astragalus polysaccharide sustained release microsphere. The astragalus polysaccharide sustained release microsphere prepared by virtue of the preparation method has an ideal targeting effect, can slowly release after being administrated, is long in action time and is capable of increasing the concentration of astragalus polysaccharide in target organs, and the high local blood concentration is avoided; the astragalus polysaccharide sustained release microsphere is safe and environmentally friendly and has high treatment effect to radiation pneumonitis and little side effect; the operation is simple and convenient, a process is stable, and industrial production is easily realized; the astragalus polysaccharide sustained release microsphere is high in encapsulation efficiency and drug loading capacity; the skin of a patient is smooth and fine after the administration.

Description

technical field [0001] The invention relates to a sustained-release microsphere, in particular to an astragalus polysaccharide sustained-release microsphere for treating radiation pneumonitis and a preparation method thereof, belonging to the field of biomedicine. Background technique [0002] Radiation therapy is one of the effective methods for treating malignant tumors, but radiation pneumonitis often occurs 1 to 6 months after irradiation. The incidence rate of radiation pneumonitis reported in China is 8.25-29.60%, and it is 19.0-37.2% in foreign reports. Radiation pneumonitis is a common complication of lung cancer, breast cancer, esophageal cancer, radiotherapy for head and neck tumors, bone marrow transplantation preconditioning, nuclear radiation events, and nuclear weapon injuries. In the early stages of radiation pneumonitis, patients may experience varying degrees of blood toxicity, as well as symptoms such as fatigue, nausea, diarrhea, and hair loss; in the late...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/715A61K47/36A61P11/00
Inventor 张维芬孙玉卿赵立民史立宏
Owner WEIFANG MEDICAL UNIV
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