Stir-frying technology for Chinese yew powder rich in paclitaxel liposome by using membrane-ultrasonic wave method

Abstract

The invention discloses a stir-frying technology for Chinese yew powder rich in paclitaxel liposome by using a membrane-ultrasonic wave dissolving technique, belonging to the technical field of medicines. According to the invention, a traditional stir-frying method for Chinese herbal medicines is combined with advanced preparation and enrichment technologies for paclitaxel (taxane) liposome so as to process the Chinese yew powder which is rich in the paclitaxel (taxane) liposome, can be easily absorbed in oral administration and has a high efficiency anticancer effect and low toxic and side effects. The method comprises the following concrete steps: putting 95% ethanol and egg oil which are used as liquid accessories and Chinese yew powder and Chinese yew extract powder which are used as stir-frying substrates in a membrane evaporator together, carrying out stir-frying under the conditions of a constant temperature (a water bath at a temperature of 60 DEG C), pressure reduction and continuous rotation operation, carrying out hydration so as to form the paclitaxel (taxane) liposome and allowing the paclitaxel (taxane) liposome to be enriched in Chinese yew powder particles by using a vacuum / pressure method, thereby allowing the Chinese yew powder to become an anticancer Chinese herbal medicine which is rich in the paclitaxel (taxane) liposome, can be easily absorbed in oral administration and has high efficiency and low toxic and side effects.

Description

technical field The invention relates to a technique for preparing yew powder rich in paclitaxel liposome by film ultrasonic method, which belongs to in the field of medical technology. Background technique In recent years, due to the infiltration of modern pharmaceutical technology on the processing technology of traditional Chinese medicine powder, the efficacy of traditional Chinese medicine powder has been significantly improved, and new types of powders such as concentrated traditional Chinese medicine powder, nanometer traditional Chinese medicine powder, and traditional Chinese medicine ultrafine particles have appeared successively. For most Chinese herbal medicines, it avoids the disadvantages of troublesome decoction and inconvenient taking, and enables the active ingredients of the medicine to be concentrated or fully released to a certain extent, thereby greatly improving the efficacy of the medicine powder. However, grinding, releasing, and concentrating are o...

AI Technical Summary

Problems solved by technology

In addition, paclitaxel oral preparations (decoction pieces, capsules) have not been widely used so far. An important reason is that the intestinal cells have a low absorption rate of paclitaxel (<6%).