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Preparation of lindera glauca essential oil inclusion compound and vaporized inhalation type administration method of lindera glauca essential oil inclusion compound

A technology of volatile oil inclusion compound and administration method, applied in the field of traditional Chinese pharmacy, can solve the problems of unstable nature of volatile oil, irritation of volatile oil, affecting the curative effect of preparations, etc., achieve strong antioxidant activity, reduce drug side effects, and relieve throat discomfort Effect

Inactive Publication Date: 2020-07-10
YUNNAN LVXIN BIOLOGICAL PHARMA CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, volatile oils are often irritating, which is not conducive to medication, and volatile oils are unstable in nature, volatile in preparations, and affect the efficacy of preparations. Therefore, other technologies are used to make up for these deficiencies, such as making clathrates to increase stability and reduce irritation. sex

Method used

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  • Preparation of lindera glauca essential oil inclusion compound and vaporized inhalation type administration method of lindera glauca essential oil inclusion compound
  • Preparation of lindera glauca essential oil inclusion compound and vaporized inhalation type administration method of lindera glauca essential oil inclusion compound
  • Preparation of lindera glauca essential oil inclusion compound and vaporized inhalation type administration method of lindera glauca essential oil inclusion compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1. Extraction of volatile oil of mountain pepper

[0027] Weigh 500g of the crushed peppercorn fruit, add 8 times the amount of water to soak for 2h, carry out according to the method A under the determination method of volatile oil in the fourth part of the "Chinese Pharmacopoeia" 2015 edition 2204, use steam distillation to extract for 6h, and use anhydrous sodium sulfate After dehydration, 22.5 mL of light yellow oily liquid was obtained, and the calculated volatile oil yield was 4.5%. The prepared volatile oil is stored in the refrigerator.

[0028] 2. Preparation of clathrate of volatile oil of mountain pepper

[0029] (1) Use the saturated aqueous solution method for clathration, weigh 100g of HP-β-CD and place it in a stoppered Erlenmeyer flask, add an appropriate amount of distilled water, heat to dissolve it completely, then lower it to 30°C, and stir at a constant temperature.

[0030] (2) Take 10mL of volatile oil of mountain pepper, dilute it with 10mL of ...

experiment example 2

[0046] Experimental example 2 inclusion process evaluation

[0047] The oil content of inclusion compound and inclusion rate of volatile oil were used as the evaluation indexes of volatile oil inclusion process. The calculation formula is:

[0048] Inclusion rate of volatile oil = recovery of volatile oil in clathrate / (addition of volatile oil × blank recovery rate) × 100%. Oil content of inclusion compound = oil content of inclusion compound / weight of inclusion compound × 100%.

[0049] The specific method is as follows:

[0050] (1) Determination of the blank recovery rate of the volatile oil of mountain pepper

[0051] In a 500mL round bottom flask, add 300mL of pure water and 1mL of volatile oil of mountain pepper, and operate according to Method A of 2204 volatile oil determination method in the four general rules of the 2015 edition of Chinese Pharmacopoeia, read the volume of volatile oil, and calculate the blank recovery rate.

[0052] .

[0053] (2) Determinati...

experiment example 3

[0061] Experimental example 3 Stability experiment of clathrate of peppercorn volatile oil

[0062] Citral is the main component of the volatile oil of mountain pepper. In this experiment, the content of citral was used as a characterization index to investigate the stability of the inclusion compound and the mixture without inclusion.

[0063] The specific method is as follows:

[0064] (1) Preparation of the mixture containing the volatile oil of mountain pepper, HP-β-CD, cannabis wax, borneol, and menthol: take the raw materials with the same feeding ratio as the clathrate in Example 1, put them in a mortar and grind them evenly ,spare.

[0065] (2) Put the clathrate prepared in Example 1 and the above mixture into a jar, place it in a constant temperature and humidity chamber with a temperature of 60°C and a humidity of 75%, and investigate for 7 days. Samples were collected on the 0th, 1st, 3rd, 5th, and 7th day, and the quantitative determination of citral was carried ...

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Abstract

The invention provides the preparation of a lindera glauca essential oil inclusion compound and a vaporized inhalation type administration method of the lindera glauca essential oil inclusion compound, and belongs to the technical field of traditional Chinese pharmacology. Lindera glauca essential oil has broad-spectrum anti-bacterial, anti-asthmatic, anti-allergic and muscle relaxation smoothingeffects, but the essential oil is not stable, therefore, the hydroxypropyl-beta-cyclodextrin inclusion compound can be prepared by using the lindera glauca essential oil and hemp wax, borneol and menthol. Administration can be performed by using an electric heater; the electric heater can make the inclusion compound vaporized; and patients can inhale the vaporized drug into oral cavity in a way similar to smoking, so that the drug can enter respiratory tracts; and the inclusion compound can achieve anti-bacterial, anti-tussive, expectorant, anti-asthmatic effects, and can also be used for treating chronic bronchitis.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to the preparation of clathrate of volatile oil of mountain pepper and its gasification and inhalation administration method. Background technique [0002] Chronic bronchitis is chronic non-specific inflammation of the trachea, bronchial mucosa and surrounding tissues. The main reason is that repeated infections of viruses and bacteria form chronic non-specific inflammation of the bronchi. The main clinical symptoms are cough, sputum, or wheezing that lasts for 2 or more consecutive years and lasts for more than 3 months every year. It is a common disease of the respiratory system and a common disease that seriously endangers health. In recent years, with the worsening of environmental pollution and the increasing number of smokers, the incidence of chronic bronchitis worldwide is on the rise year by year. If the disease is not treated in time, it may develop into...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/54A61K47/69A61K36/60A61K9/72A61P31/04A61P11/14A61P11/06A61P11/10A61P29/00A61P37/08A61P11/00A61K31/045
CPCA61K9/0078A61K31/045A61K36/54A61K36/60A61K2236/37A61K47/6951A61P11/00A61P11/06A61P11/10A61P11/14A61P29/00A61P31/04A61P37/08A61K2300/00
Inventor 王钲霖刘胜贵马海悦付彬彬李智高孔令羽薛红芬蒋永昌
Owner YUNNAN LVXIN BIOLOGICAL PHARMA CO LTD
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