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2 results about "Vesicle/vacuole" patented technology
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Membrane-enclosed spherules that serve as subcellular packaging for nutrients, waste, or secretory compounds, or as vehicles to and from the cell membrane; do not use for artificial lipid vesicles (see MEMBRANE MODEL).
Cell membrane bionic nano-vesicle loaded with resveratrol carbon dots and application of cell membrane bionic nano-vesicle
The invention is applicable to the technical field of biological medicine, and provides a resveratrol carbon dot-loaded cell membrane bionic nano-vesicle and application thereof, and the resveratrol carbon dot-loaded cell membrane bionic nano-vesicle is prepared by the following preparation process: mixing pure trans-resveratrol with ultrapure water, adjusting the pH value until complete dissolution, reacting the solution to obtain a carbon dot solution, centrifuging, filtering with a filter membrane, dialyzing and purifying to obtain the resveratrol carbon dot-loaded cell membrane bionic nano-vesicle. Carrying out rotary evaporation and freeze-drying to obtain RES CDs; and dropwise adding Cy7 into the DSPE-PEG solution, stirring overnight, dialyzing to remove free Cy7 to obtain Cy7-coated PEG, and mixing TM4-M, RES CDs and Cy7-coated PEG to obtain the resveratrol carbon dot-loaded cell membrane bionic nano-vesicles RCD-coated PCy-coated EVs. The invention also discloses a preparation method of the resveratrol carbon dot-loaded cell membrane bionic nano-vesicles RCD-coated PCy-coated EVs and application of the resveratrol carbon dot-loaded cell membrane bionic nano-vesicles. The vesicles based on the supporting cell membrane prepared by the invention can specifically deliver the resveratrol carbon dots to the blood testis barrier and treat spermatogenesis disorder.
Owner:HUANGHUAI UNIV
Method for constructing gram-negative bacterial outer membrane-derived nanovesicles and use thereof
The present invention relates to a method for preparing Gram-negative bacterial outer membrane-derived nanovesicles (OMNVs) and uses thereof. Additionally, the present invention provides a method for treating or diagnosing cancer using OMNVs. Furthermore, the present invention provides a method for delivering therapeutic or diagnostic substances to target cells or tissues by loading them into OMNVs. Also, the present invention provides a method for preventing and treating various diseases, including cancer and bacterial / viral infections, by co-administering OMNVs with antigens or administering OMNVs expressing antigens.
Owner:POSTECH ACADEMY INDUSTRY FOUNDATION