Surfactant Mixtures for Improving the Deposition of Active Substances and for Reducing the Skin Irritant Action

a surfactant and mixture technology, applied in the field of surfactant mixtures, can solve the problems of large amount of costly active substances that have to be incorporated, and undesired skin irritation is often observed, and achieve the effect of increasing the effective effect of active substances and more cost-effectiveness

Inactive Publication Date: 2012-07-19
IFAC INST FUR ANGEWANDTE COLLOIDTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0005]If the effectiveness of the active substances could be increased during use, it would be possible to make do with smaller amounts, meaning that the cosmetic or pharmaceutical formulations could be produced more cost-effectively.

Problems solved by technology

This procedure has the disadvantage that in most cases upon use only small amounts of the active substances remain on the skin, which can develop their effect there.
This leads to large amounts of costly active substances having to be incorporated into the formulations in order to achieve a desired effect.
However, when suitably high amounts of active substances are used in the rinse-off formulations, an undesired skin irritation is often observed when the formulations are used.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Base Formulation

[0067]30 parts by weight of sodium lauroyl lactylate, 15 parts by weight of sodium cocoyl isethionate, 30 parts by weight of sodium lauroyl glutamate and 25 parts by weight of water were heated together to 60 degrees C. and stirred until a homogeneous mixture was formed. The mixture had a pH of 6.6. It was used as phase A in the other examples.

example 2

[0068]5% of the phase A were added to 12% strength aqueous ether sulfate solution. This mixture of 5% of the phase A and 12% of ether sulfate in water was applied to the skin of 20 test-subjects in a human patch test. For comparison, a 12% strength aqueous ether sulfate solution was applied to other skin areas. In contrast to the comparison solution, the solution which comprised phase A had a pleasantly silky feel on the skin, and skin irritations were reduced to zero. In comparison to this, when the 12% strength aqueous ether sulfate solution was used on its own, skin irritations were experienced by the subjects.

[0069]This clearly shows that the phase A according to the invention reduces the irritation potential of customary rinse-off products. Typically, the phase A according to the invention can be added to a shampoo or skin-cleansing product in amounts of, for example, 1 to 10% by weight.

example 3

Antidandruff Shampoo

[0070]3.5 parts by-weight of sodium lauryl ether sulfate, 3.0 parts by weight of the phase A from example 1, 0.2 part by weight of octopyrox, 3.0 parts by weight of NaCl and 87.3 parts by weight of demineralized water were homogenized for 1 minute in the Turrax at 8000 rpm at room temperature after phase A and octopyrox have been mixed beforehand at 60 degrees C. A pH of 7.2 resulted, which was then adjusted to 6.6. Using the formulation according to the invention it was possible to establish a slightly acidic pH without octopyrox crystallizing out.

[0071]A comparison composition was prepared from 3.5 parts by weight of sodium lauryl ether sulfate, 0.5 parts by weight of octopyrox, 3 parts by weight of NaCl and 93 parts by weight of demineralized water. The pH was 9.0 and could not be adjusted to neutral since otherwise octopyrox would crystallize out. The basic pH means that the composition is not skin-friendly.

[0072]The antidandruff shampoo according to the inve...

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Abstract

A cosmetic or pharmaceutical rinse-off formulation contains 0.2% by weight to 20% by weight of a phase A; 0.1% by weight to 50% by weight of an active substance; a detergent; and the remainder being water. The phase A is a mixture of 20% by weight to 90% by weight of a surfactant mixture of isethionates, acyl lactylates and one of alkyl glutamates and alkyl glucosides and 10% by weight to 80% by weight of water, alcohol, polyol or mixtures thereof. The phase A forms multilamellar vesicles. The cosmetic or pharmaceutical rinse-off formulation is a clear product with the multilamellar vesicles of phase A having an average diameter of less than 100 nm.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a divisional of application Ser. No. 10 / 555,414 having a filing dated of Oct. 12, 2006, said application being a national stage filing of international application No. PCT / EP2004 / 04863 having an international filing date of 06 May 2004 and designating the United States, said international application claiming a priority date of 07 May 2003 based on prior filed international application PCT / EP2003 / 04788, the entire contents of the aforesaid application Ser. No. 10 / 555,414 and the aforesaid international applications being incorporated herein by reference.BACKGROUND OF THE INVENTION[0002]The invention relates to the use of mixtures of surfactants for reducing the skin irritant action of cosmetic and / or pharmaceutical formulations which are applied to the skin. Additionally, the surfactant mixtures should serve for the targeted encapsulation and improvement in the application of active substances to the skin. Here, active...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K8/02A61K31/60A61K36/00A61K31/20A61K31/695A61K36/15A61K36/752A61K36/537A61K36/13A61K36/328A61K35/12A61K9/00A61K36/73A23L27/00A61K8/11A61K8/37A61K8/44A61K8/46A61K8/49A61K8/60A61Q5/00A61Q5/02A61Q13/00A61Q19/10C11D3/50C11D17/00
CPCA61K8/0295C11D17/0026A61K8/37A61K8/44A61K8/466A61K8/4926A61K8/604A61K2800/413A61K2800/596A61K2800/75A61Q5/006A61Q5/02A61Q13/00A61Q19/00A61Q19/10C11D3/505A61K8/11
Inventor DAHMS, GERD
Owner IFAC INST FUR ANGEWANDTE COLLOIDTECH
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