39results about How to "Eliminate drug resistance" patented technology

The invention relates to the technical field of enzyme preparations, in particular to a compound preparation capable of substituting feed antibiotics. The compound preparation capable of substitutingfeed antibiotics is prepared from glucose oxidase, microecological compositions, Chinese herbal medicine extract and functional oligosaccharides. The compound preparation capable of substituting feedantibiotics has no toxic or side effect on animals, is not easy to be absorbed in the intestinal tracts of the animals, has little residual amount in the body or is easy to eliminate in a short time,does not induce the generation of drug-resistant bacteria, has strong stability in feed, can tolerate the gastrointestinal degradation effect of the animals, is easy to decompose, does not affect theenvironment, does not affect the palatability of the feed, does not destroy the normal intestinal flora of the animals, can kill or inhibit the growth of pathogenic bacteria, can enhance body resistance, can improve the utilization rate of the feed and promote the growth of the animals, and has good compatibility.

The invention relates to an anti-helicobacter pylori oral preparation. The anti-helicobacter pylori oral preparation is prepared from, by weight, 6-12 parts of anti-helicobacter pylori egg yolk immunoglobulin, 2-5 parts of lactoferrin and 2-5 parts of chlorophyll in barley green. According to the anti-helicobacter pylori oral preparation, helicobacter pylori infection can be cured under the condition that no antibiotic is used, therefore, the cure rate is increased, the possibility that a pathogen generates drug resistance and the potential of relapse after curing are eliminated, and meanwhile the adverse effect rate is greatly decreased.

The invention relates to an application of lavender essential oil as a feeding antibiotic substitute in daily ration of broiler, which belongs to the technical field of broiler raising, in particular to an application of lavender essential oil which can replace the feeding antibiotic in daily ration of broiler. By the invention, the lavender essential oil is added to the daily ration of broiler in a certain proportion, which not only can completely replace various feeding antibiotics in the formula of the daily ration of broiler, but also have the functions of ensuring the health of broiler, promoting the growth of broiler, and improving the transfer efficiency of feedstuff. The application can be used in production of broiler and products thereof without adding feeding antibiotics.

The invention relates to the field of pig feeds, in particular to an antibiotic-free fermented feed for pregnancy sows and a preparation method of the antibiotic-free fermented feed. The antibiotic-free fermented feed comprises the following components in parts by weight of 500-630 parts of corn, 100-150 parts of soybean meal, 20-60 parts of fermenting raw materials, 100-200 parts of soybean hulls, 8-20 parts of dicalcium phosphate, 5-15 parts of soybean oil, 10-20 parts of stone powder, 1-5 parts of composite amino acids, 1-5 parts of composite multiple vitamins, 1-5 parts of minerals, 2-8 parts of sodium chloride, 0.5-1 part of choline chloride, 1-4 parts of enzyme preparations, 0.2-1.4 parts of plant extracts, and 0.4-1.8 parts of microecological preparations. According to the antibiotic-free fermented feed for pregnancy sows and the preparation method of the antibiotic-free fermented feed disclosed by the invention, the antibiotic-free fermented feed is a safe environmental-friendly healthy antibiotic-free feed; the application method is used for cooperation, and the pregnancy sows are fed, so that solving the problem of propagation of the sows in a present large-scale piggeryis facilitated, and economic benefits are increased.

This application provides an application of a medicine in the preparation of drugs for treating metastatic encephaloma and related diseases thereof. The medicine includes at least one TRPV4 agonist capable of promoting calcium ion influx of a TRPV4 signal channel, and the metastatic encephaloma and related diseases thereof include metastatic encephaloma, diseases arising during the formation of metastatic encephaloma, complications and sequelae caused by metastatic encephaloma, and diseases related to metastatic encephaloma. The medicine is applied in the preparation of the drugs for treatingmetastatic encephaloma-related diseases, a significant anti-tumor effect can be played through a clear mechanism of action, the therapeutic effects are good, and the application prospects are good.

The invention provides a drug for inhibiting brain tumor and application thereof. The drug for inhibiting the brain tumor comprises at least one TRPV4 agonist capable of promoting calcium ion internalflow of a TRPV4 signal channel. The drug has a good treatment effect on brain tumors and related diseases thereof, and has a good application prospect in treatment of brain tumors and related diseases thereof. The drug is applied to medicines for treating brain tumors and related diseases thereof, can reduce toxic and side effects generated in the clinical treatment process of the brain tumors and the related diseases thereof and improve the treatment effect of the brain tumors and the related diseases thereof.

A disinfecting liquid for skin mucous and wound contains chlorhexidine acetate, organic tellurium compound or hydrochloride of inorganic tellurium, propanetriol, and VA. Its advantages are broad spectrum, high disinfecting effect and durability, and high safety.

The invention discloses a preparation method of antibacterial polyester fiber. The method comprises the following steps that (1) a polyester chip is mixed with a mixed solution and soaked for 2-4 hours, and then filtered; the polyester chip is soaked in water for 2-4 hours, then filtered, and dried to obtain a pretreated polyester chip; (2) the above pretreated polyester chip, kaolin, medical stone powders, a carbon nanotube, gamma-aminopropyltriethoxysilane and polyethylene wax are stirred and mixed, and dried to obtain a mixture; and (3) the above mixture is fused, extruded and spun to obtain the antibacterial polyester fiber. The antibacterial polyester fiber of the invention has good antibacterial performance.

The invention provides a method for preparing a compounded injection preparation for treating esophagus cancer. The method comprises the following steps: taking raw plasma out from a blood bank according to different blood groups; extracting low density lipoproteins from the raw plasma through the centrifugation and density adjustment treatment; preparing and obtaining targeting drug vectors by the purification of the low density lipoproteins; then compounding the targeting drug vectors with aclacinomycin targeting drugs which are used for treating cancer; and injecting the compounded low density lipoprotein-aclacinomycin drugs into a patient matched with the blood group of drug raw plasma to achieve the purpose of esophagus cancer treatment. The clinical practices prove that the low density lipoprotein-aclacinomycin compounded injection preparation achieves satisfactory curative effects in clinical esophagus cancer treatment without obvious toxic and side effects of chemotherapy, is used for treating 252 esophagus cancer sufferers with the effective rate reaching 100% and the survival rate above 96%, and has good values of popularization and utilization.

The invention provides a method for preparing colon cancer chemotherapy medicament, which comprises the following steps: weighting the raw material of plasma in the blood bank, centrifuging the plasma, adjusting the density of the plasma, and extracting low-density lipoprotein from the plasma; purifying the low-density lipoprotein to obtain the carrier of the target medicament; compounding the low-density lipoprotein with the target aclacinomycin medicament for treating colon cancer; and injecting the compound of the low-density lipoprotein and the target aclacinomycin medicament into the body of the patient whose blood type is the same as the raw material of plasma to treat the colon cancer. The clinical practice shows that the injection of the compound of the low-density lipoprotein and the target aclacinomycin medicament has the satisfactory effect for treating the colon cancer clinically and can not cause obvious toxic and side reaction of chemotherapy. Used for treating the colon cancer of 185 patients, the injection of the compound of the low-density lipoprotein and the target aclacinomycin medicament achieves the effective rate of 100 percent and the survival rate of more than 96 percent in three years, thereby having high popularization and application values.

The invention relates to the technical field of biomedical engineering, and provides an application of an FAK inhibitor in preparation of an SHP2 inhibitor sensitizing drug, especially an applicationof the FAK inhibitor in preparation of a colorectal cancer SHP2 inhibitor sensitizing drug. An experiment verifies that an FAK inhibitor can eliminate the drug resistance phenomenon of an SHP2 inhibitor; and after the two inhibitors jointly act, feedback activation of AKT signals after SHP2 inhibition can be universally eliminated, the AKT signals are further inhibited, and the effect of obviouslysynergistically killing tumor cells is achieved, for example, the clone formation capacity of CRC cells and the growth speed of colorectal cancer bodies can be remarkably inhibited. Therefore, the invention provides new exploration for improving sensitivity of the SHP2 inhibitor, is beneficial to improving drug sensitivity of malignant tumors, and has a certain clinical application prospect.

The invention provides a preparation method of a compound preparation for treating lung cancer, and the method comprises the following steps: raw material plasma is respectively taken from a blood bank according to the different blood types, low-density lipoprotein is extracted from the plasma by centrifugation and density adjustment treatment, a targeted-drug carrier is prepared by extracting and purifying the low-density lipoprotein, then the targeted-drug carrier is compounded with an aclacinomycin targeted-drug for treating cancer, and the low-density lipoprotein-aclacinomycin drug after the compound is injected into a patient with the same blood type of the raw material plasma of the drug to achieve the purpose of treating the lung cancer. The clinical practices prove that the low-density lipoprotein-aclacinomycin compound injection preparation can obtain the satisfying efficacy on the clinical treatment of the lung cancer without obvious chemotherapy toxicity or side effects; in 352 cases of the patients with the lung cancer, the effective rate achieves 100 percent, and the 3-year survival rate is more than 96 percent, thereby having great promotion and use values.

The invention provides a preparation method of composite injection for the chemotherapy of colon cancer, which comprises the steps of: respectively taking raw material blood plasma from a blood bank according to different blood types; centrifuging and adjusting density; extracting low-density lipoprotein; preparing carrier of targeted medicine by purifying the low-density lipoprotein; compositing with aclacinomycin targeted medicine for treating cancer; and injecting the composite low-density lipoprotein-aclacinomycin medicine into the human body with the same type as the raw material blood plasma to achieve the aim of treating the colon cancer. The clinical practice proves that the low-density lipoprotein-aclacinomycin composite injection can obtain satisfactory treatment effect on clinically treating the colon cancer, has no obvious chemotherapy toxic and side effects, has effective rate at 100% for treating 185 colon cancer patients, has 3 years survival rate at more than 96%, and has good popularization and use value.