Process for producing composite injection formulation for treating esophagus cancer

A technology for injection preparation and esophageal cancer, which is applied to the preparation method of compound intravenous injection preparation and the preparation field thereof, and can solve the problems of reducing human immune function, affecting chemotherapeutic drugs, killing cancer cells and damaging healthy cells, etc.

Inactive Publication Date: 2009-05-13
曹莹莹
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Problems solved by technology

At present, the common deficiency of the chemotherapeutic drugs used in the chemotherapy of various tumors is that the anti-tumor chemotherapeutic drugs lack selectivity. While killing cancer cells, they also damage healthy cells, reduce the immune function of the human body, and cause many toxic effects. Side effects affect the clinical application of chemotherapy drugs. In order to improve the efficacy of anti-tumor drugs and reduce the damage and toxicity to normal cells, the medical community has tried many times to use antibodies, liposome

Method used

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Embodiment Construction

[0017] The preparation method of the compound injection for the treatment of esophageal cancer of the present invention, its preparation steps are as follows:

[0018] 1) Preparation of low-density lipoprotein:

[0019] (1) Preparation of KBr-NaEDPA solution: Weigh 1.080 g of KBr, add 0.0022 mol / L NaEDPA 100 ml aqueous solution, dissolve and stir evenly for later use.

[0020] (2) According to the blood type of the plasma raw material stored in the blood bank, take 200ml of plasma respectively, centrifuge at 300r / m for 10 minutes, take the supernatant, adjust the density to 1.01ρ with KBr-NaEDPA solution, control the temperature at 4°C, and centrifuge at 47000r Centrifuge for 18 hours at a speed of 1 / m, suck off the VLDL solution in the upper layer, and leave the remaining part for later use;

[0021] (3) Mix the remaining liquid after absorbing the VLDL in the upper layer, then use KBr-NaEDPA solution to adjust the density to 1.063ρ, control the temperature at 4°C, and centr...

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Abstract

The invention provides a method for preparing a compounded injection preparation for treating esophagus cancer. The method comprises the following steps: taking raw plasma out from a blood bank according to different blood groups; extracting low density lipoproteins from the raw plasma through the centrifugation and density adjustment treatment; preparing and obtaining targeting drug vectors by the purification of the low density lipoproteins; then compounding the targeting drug vectors with aclacinomycin targeting drugs which are used for treating cancer; and injecting the compounded low density lipoprotein-aclacinomycin drugs into a patient matched with the blood group of drug raw plasma to achieve the purpose of esophagus cancer treatment. The clinical practices prove that the low density lipoprotein-aclacinomycin compounded injection preparation achieves satisfactory curative effects in clinical esophagus cancer treatment without obvious toxic and side effects of chemotherapy, is used for treating 252 esophagus cancer sufferers with the effective rate reaching 100% and the survival rate above 96%, and has good values of popularization and utilization.

Description

technical field [0001] The invention relates to a preparation for treating esophageal cancer, in particular to a preparation method of a compound intravenous injection preparation for treating esophageal cancer and a preparation method thereof. Background technique [0002] With the aggravation of environmental pollution and changes in people's diet structure, the incidence and mortality of esophageal cancer are increasing year by year, seriously endangering the health of the people. In the treatment plan of esophageal cancer, chemotherapy is still the main means in its comprehensive treatment measures. At present, the common deficiency of the chemotherapeutic drugs used in the chemotherapy of various tumors is that the anti-tumor chemotherapeutic drugs lack selectivity. While killing cancer cells, they also damage healthy cells, reduce the immune function of the human body, and cause many toxic effects. Side effects affect the clinical application of chemotherapy drugs. In...

Claims

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Application Information

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IPC IPC(8): A61K47/48A61K47/42A61K31/704A61P35/00C07K14/47A61K47/64
Inventor 曹莹莹
Owner 曹莹莹
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