Vitis botanical extractive, its preparation method and its novel usage as an antibacterials synergist
A technology of plant extracts and antibacterial drugs, applied in the direction of antibacterial drugs, medical preparations containing active ingredients, pharmaceutical formulas, etc., to achieve the effect of enhancing bactericidal efficacy, eliminating bacterial resistance and high product yield
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Embodiment 1
[0051]A plant extract of the genus Vitis, which uses water extraction, ethanol extraction and glycerin extraction to separate and purify grape fruit, grape roots, vines and leaves, grape skins, and grape seeds to obtain an extract. After mixing the separately obtained extracts, the final concentration drying, spray drying and freeze drying are carried out to obtain powders containing grape stilbene, resveratrol, oleanolic acid, β-sitosterol, gallic acid and flavonoids状 extracts.
Embodiment 2
[0052] Example 2 Separation and extraction
[0053] Soak the raisins in distilled water for 30 minutes, and then decoct them at 100°C for 30 minutes. After filtering to remove the residue, the active substances are separated and purified by resin adsorption, and finally sterilized at 100°C for 10 minutes to obtain extract 1 After crushing the grape roots, vines and leaves, add ethanol, filter to remove the residue, and then separate and purify the active substances by resin adsorption, and finally filter and sterilize to obtain the extract 2; After soaking the grape skins in distilled water, add acidic ethanol and filter Remove the residue, and then separate and purify the active substance by silica gel column chromatography, and finally filter and sterilize to obtain the extract 3. After crushing the grape seeds, add glycerin to extract at 150℃, filter to remove the residue, and then separate and purify by resin adsorption The active substance is finally filtered and sterilized t...
Embodiment 3
[0054] Example 3 Determination of active ingredients
[0055] The content of resveratrol was determined by HPLC; the content of flavonoids, β-sitosterol, and gallic acid were determined by spectrophotometry, GC-MS and TLC.
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