8 results about "Antimicrobial medicament" patented technology

The application belongs to the technical field of biomedical engineering, and particularly relates to a visual hydrogel wound dressing, a preparation method and application thereof. The visual hydrogel wound dressing provided by the application is a hydrogel fiber membrane; the hydrogel fiber membrane comprises PUA fibers and antibacterial agent-containing nanovesicles dispersed in the PUA fibers; the component of the PUA fibers is a PUA polymer; the preparation raw material of the PUA polymer comprises aqueous polyurethane acrylate and alginate; the antibacterial agent-containing nanovesicles comprise nanovesicles and antibacterial agents loaded in the nanovesicles; and the nanovesicles are formed by PVP-PLA-PVP amphiphilic block copolymer. The wound dressing provided by the application can effectively promote wound healing through the synergistic effect of efficient antibiosis, drug sustained release and visual diagnosis.

Systems and Methods for determining response of microbe cultures to antimicrobials by measuring properties of individual microbes and / or other culture particles. Methods include incubating microbes in liquid cultures which may contain antimicrobials and growth media, detecting individual microbes and particles, and measuring their properties, which may include the mass of individual microbes and particles. Measurement data, such as masses of a plurality of individual microbes or particles, may be collected after an incubation duration. These data may be analyzed to determine susceptibility of microbes to one or more antibiotics. Measurement may be performed after incubation durations shorter than required to produce growth by microbe replication, and analysis may include assessment of metrics other than the growth of the culture. The method enables measurement of susceptibility at earlier times than needed for sufficient microbe replication required by many existing techniques enabling accurate results with relatively minimal sample volumes of a culture.

Provided are aqueous lignin solutions containing lignin solvated in Good's Buffers. The aqueous lignin solutions can be used in a variety of applications including biomedical research and in manufacturing a variety of lignin containing products including food grade and biomedical products. The aqueous lignin solutions can also be used in the treatment of microbial infection, as an adjuvant in antimicrobial therapeutics or therapy, and in forming antimicrobial products. Methods of making and using aqueous lignin solutions are also described.

Systems and Methods for determining response of microbe cultures to antimicrobials by measuring properties of individual microbes and / or other culture particles. Methods include incubating microbes in liquid cultures which may contain antimicrobials and growth media, detecting individual microbes and particles, and measuring their properties, which may include the mass of individual microbes and particles. Measurement data, such as masses of a plurality of individual microbes or particles, may be collected after an incubation duration. These data may be analyzed to determine susceptibility of microbes to one or more antibiotics. Measurement may be performed after incubation durations shorter than required to produce growth by microbe replication, and analysis may include assessment of metrics other than the growth of the culture. The method enables measurement of susceptibility at earlier times than needed for sufficient microbe replication required by many existing techniques enabling accurate results with relatively minimal sample volumes of a culture.

This invention discloses an artificial intelligence-based antimicrobial substance management information system, relating to the field of medical information. It obtains multiple historical antimicrobial grade sequences sorted by time from historical antimicrobial treatment data and generates a gradient sequence based on the difference between adjacent time steps. The system calculates the length of continuous gradients using a sliding window, reflecting the trend of continuous escalation or deterioration of the antimicrobial grade. In the self-attention layer of the Transformer network, time steps with larger continuous gradient lengths are assigned higher attention weights, thereby highlighting key change segments in the antimicrobial grade sequence. The Transformer network is trained based on the historical antimicrobial grade sequences to obtain an antimicrobial grade prediction model. This invention can utilize the characteristics of antimicrobial grade changes to achieve intelligent prediction and optimized management of future antimicrobial drug grades.

The present invention relates to the development of a microencapsulated vaccine containing inactivated Streptococcus agalactiae, together with the adjuvants beta glucan and mineral oil, to be administered orally to fish together with feed in pelletised form or coated with the vaccine. In addition, the invention relates to the use of this vaccine to immunise fish, more specifically Nile tilapia (Oreochromis niloticus) to activate both innate and adaptive (humoral and cellular) intestinal mucosal immunity and protect tilapia against streptococcosis. Such a vaccine can be applied in intensive fishing production systems, with the aim of reducing fish mortality, reducing the use of antimicrobials and not causing environmental damage, being easy to administer and control, reducing fish handling, and being suitable for immunising large numbers of animals at the same time without stress and at low cost.

The invention provides a method for preparing micro-nano particles based on interface instability and application of the micro-nano particles, and belongs to the technical field of biomedical materials. The method comprises the following steps: firstly, quickly freezing a water-soluble macromolecular solution to form a precursor with an ice crystal network; and then heating and aging at low temperature, so that the interface generated by substances at the ice crystal interface is unstable, and micro-nano particles are formed. According to the preparation method, an aqueous solution system is completely adopted, no chemical reagent needs to be added in the whole preparation process, the process is simple, and therefore the problems that in the prior art, chemical reagents are used and left, biocompatibility is reduced, and the yield is low are solved. Besides, water-soluble functional substances can be added in the preparation process of the prepared micro-nano particles to obtain the micro-nano particles loaded with the functional substances, so that the micro-nano particles can be used in the fields of antibiosis, drug carriers, diagnostic imaging contrast agents, gene transfection and the like.

A bacterial antimicrobial resistance prediction method and system, a hierarchical configuration unit divides resistance prediction elements into patient risk levels, microbial feature levels, regional prevalence levels, clinical rule levels and drug property levels, each level includes initial attribute values and level-specific dynamic rule sets; a data processing unit acquires real-time clinical data, each level independently processes data through its level-specific dynamic rule set, and converts initial attribute values into target attribute values; a decision superposition unit superimposes the target attribute values of each level according to the weight priority of each level to generate a bacterial antimicrobial resistance prediction result and an antibacterial drug recommendation scheme; a report output unit outputs a visual report. The present application realizes precise, interpretable and highly adaptive bacterial antimicrobial resistance prediction through hierarchical design and rule monitoring separation architecture, while reducing the dependence on high-performance equipment and adapting to the use scenarios of primary medical institutions.