Antibacterial composition, temperature-sensitive antibacterial film prepared by using antibacterial composition and implant material
An antibacterial composition and antibacterial agent technology, applied in the field of antibacterial implant materials, can solve problems such as poor targeting, microbial or bacterial resistance, etc.
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Embodiment 1
[0042] The present embodiment prepares thermosensitive antibacterial film according to the following method:
[0043] (1) Prepare PLGA polymer solution: dissolve 10g PLGA (Mw=80,000, LA / GA=75 / 25) in 40mL THF and acetone mixed solvent (the volume ratio of THF to acetone is 1 / 1), and prepare the concentration As a 25% (W / V) solution, stir at room temperature for 3 hours.
[0044] (2) Preparation of PNIPAM colloid: Dissolve 4g of N-isopropylacrylamide, 0.06g of potassium persulfate and 0.16g of N,N-dimethylacrylamide in 160g of deionized water containing 0.3g of gelatin, and heat to 75°C for stability , add 2g vancomycin, continue heating under nitrogen protection for 2 hours, then centrifuge to separate the PNIPAM colloid containing vancomycin, and wash with deionized water three times-centrifugation to obtain cross-linked PNIPAM colloid. The prepared PNIPAM colloid has a uniform particle size and a diameter of 50nm to 500nm, and the loading rate of vancomycin (relative to the ...
Embodiment 2
[0049] The present embodiment prepares thermosensitive antibacterial film according to the following method:
[0050] (1) Preparation of polylactic acid polymer solution: Dissolve 10g of polylactic acid (Mw=500,000) in 40mL of THF and acetone mixed solvent (the volume ratio of THF to acetone is 1 / 1), and prepare a concentration of 30% (W / V) solution was stirred at room temperature for 5 hours.
[0051] (2) Preparation of PNIPAM colloid: Dissolve 10g of N-isopropylacrylamide, 0.2g of potassium persulfate and 0.3g of N,N-dimethylacrylamide in 300g of deionized water containing 0.5g of cyclodextrin, and heat to 90 ℃ stable, add 4g levofloxacin, continue heating under nitrogen protection for 2 hours, then centrifuge to separate the PNIPAM colloid containing levofloxacin, and wash with deionized water three times-centrifugation to obtain cross-linked PNIPAM colloid. The prepared PNIPAM colloid has a uniform particle size and a diameter of 100nm to 600nm, and the loading rate of l...
Embodiment 3
[0056] The present embodiment prepares thermosensitive antibacterial film according to the following method:
[0057] (1) Preparation of polycaprolactone polymer solution: Dissolve 8g of polycaprolactone (Mw=50,000) in 50mL of THF and acetone mixed solvent (the volume ratio of THF to acetone is 1 / 1), and prepare a concentration of 5 % (W / V) solution, stirred at room temperature for 2 hours.
[0058] (2) Preparation of PNIPAM colloid: Dissolve 5g of N-isopropylacrylamide, 0.1g of potassium persulfate and 0.2g of N,N-dimethylacrylamide in 200g of deionized water containing 0.4g of gelatin, and heat to 60°C Stable, add 2.5g cephalexin, continue heating under nitrogen protection for 2 hours, then centrifuge to separate cephalexin-containing PNIPAM colloid, and wash with deionized water three times-centrifugation to obtain cross-linked PNIPAM colloid. The prepared PNIPAM colloid has a uniform particle size and a diameter of 50nm to 300nm, and the loading rate of cephalexin after w...
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