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Antibacterial composition, temperature-sensitive antibacterial film prepared by using antibacterial composition and implant material

A technology of antibacterial composition and antibacterial agent, which is applied in the field of antibacterial implant materials, and can solve problems such as poor pertinence, microbial or bacterial drug resistance, etc.

Active Publication Date: 2015-04-22
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Postoperative infection is mostly exogenous, and then induces endogenous. When high fever occurs, systemic anti-infection treatment is a common clinical method, which is not very targeted. Large-dose injections can easily lead to drug resistance of microorganisms or bacteria sex

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The present embodiment prepares thermosensitive antibacterial film according to the following method:

[0043] (1) Prepare PLGA polymer solution: dissolve 10g PLGA (Mw=80,000, LA / GA=75 / 25) in 40mL THF and acetone mixed solvent (the volume ratio of THF to acetone is 1 / 1), and prepare the concentration As a 25% (W / V) solution, stir at room temperature for 3 hours.

[0044] (2) Preparation of PNIPAM colloid: Dissolve 4g of N-isopropylacrylamide, 0.06g of potassium persulfate and 0.16g of N,N-dimethylacrylamide in 160g of deionized water containing 0.3g of gelatin, and heat to 75°C for stability , add 2g vancomycin, continue heating under nitrogen protection for 2 hours, then centrifuge to separate the PNIPAM colloid containing vancomycin, and wash with deionized water three times-centrifugation to obtain cross-linked PNIPAM colloid. The prepared PNIPAM colloid has a uniform particle size and a diameter of 50nm to 500nm, and the loading rate of vancomycin (relative to the ...

Embodiment 2

[0049] The present embodiment prepares thermosensitive antibacterial film according to the following method:

[0050] (1) Preparation of polylactic acid polymer solution: Dissolve 10g of polylactic acid (Mw=500,000) in 40mL of THF and acetone mixed solvent (the volume ratio of THF to acetone is 1 / 1), and prepare a concentration of 30% (W / V) solution was stirred at room temperature for 5 hours.

[0051] (2) Preparation of PNIPAM colloid: Dissolve 10g of N-isopropylacrylamide, 0.2g of potassium persulfate and 0.3g of N,N-dimethylacrylamide in 300g of deionized water containing 0.5g of cyclodextrin, and heat to 90 ℃ stable, add 4g levofloxacin, continue heating under nitrogen protection for 2 hours, then centrifuge to separate the PNIPAM colloid containing levofloxacin, and wash with deionized water three times-centrifugation to obtain cross-linked PNIPAM colloid. The prepared PNIPAM colloid has a uniform particle size and a diameter of 100nm to 600nm, and the loading rate of l...

Embodiment 3

[0056] The present embodiment prepares thermosensitive antibacterial film according to the following method:

[0057] (1) Preparation of polycaprolactone polymer solution: Dissolve 8g of polycaprolactone (Mw=50,000) in 50mL of THF and acetone mixed solvent (the volume ratio of THF to acetone is 1 / 1), and prepare a concentration of 5 % (W / V) solution, stirred at room temperature for 2 hours.

[0058] (2) Preparation of PNIPAM colloid: Dissolve 5g of N-isopropylacrylamide, 0.1g of potassium persulfate and 0.2g of N,N-dimethylacrylamide in 200g of deionized water containing 0.4g of gelatin, and heat to 60°C Stable, add 2.5g cephalexin, continue heating under nitrogen protection for 2 hours, then centrifuge to separate cephalexin-containing PNIPAM colloid, and wash with deionized water three times-centrifugation to obtain cross-linked PNIPAM colloid. The prepared PNIPAM colloid has a uniform particle size and a diameter of 50nm to 300nm, and the loading rate of cephalexin after w...

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Abstract

The invention discloses an antibacterial composition, a temperature-sensitive antibacterial film prepared by using the antibacterial composition and an implant material. The antibacterial composition comprises an organic polymer selected from polylactic acid, polycaprolactone, a polylactic acid-glycolic acid copolymer and a polylactic acid-polyethylene glycol block copolymer, a blending colloid of polyisopropyl acrylamide and cyclodextrin or a blending colloid of polyisopropyl acrylamide and gelatin, and an antibacterial agent. The temperature-sensitive antibacterial film prepared by using the antibacterial composition through high-pressure electrostatic spinning can only release an antibacterial medicament when the temperature of a human body rises, so that the targeting property is very high.

Description

technical field [0001] The invention relates to the technical field of antibacterial implant materials, in particular to an antibacterial composition and a temperature-sensitive antibacterial film and implant material prepared therefrom. Background technique [0002] Fever is a typical reaction when organisms are infected by pathogens. Homeotherms, such as mice or humans, increase their body temperature to signal infection; while cold-blooded animals (poikiotherms, such as nematodes) swim to warmer environments , indicating that it is infected. And when the temperature in the body or the environment rises, the immune signal transmission pathway of the temperature-sensitive sensory factor (HSF-1) will be activated, which can explain that the function of the HSF-1 pathway is to resist the infection of foreign enemies, and it can also explain Why organisms may have a fever when they are infected. From the perspective of physiological response, fever is caused by the rapid inc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/34A61L27/54A61L27/50A61L31/06A61L31/04A61L31/16A61L31/14B05D7/24
Inventor 韩志超许杉杉
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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