Antibacterial medicament for animals and preparation method and application thereof

An antibacterial drug and animal technology, applied in the field of medicine, can solve the problems of failure, disordered use of antibiotics, unsatisfactory effect, etc., and achieve the effects of enhanced antibacterial effect of drugs, simple preparation method and improved effect

Inactive Publication Date: 2011-01-26
INST OF ANIMAL SCI & VETERINARY MEDICINE SHANDONG ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, relying solely on antibiotic treatment often leads to the problem of drug resistance of pathogenic bacteria
In particular, the current use of antibiotics in the aquaculture industry is out of order. In some farm areas, pathogenic bacteria are more resistant to antibiotics. Relying solely on antibiotics to treat drug-resistant pathogenic bacteria infection is not effective, or even completely ineffective.
Facing the increasingly serious problem of drug resistance of pathogenic bacteria, finding drugs that can solve the infection of drug-resistant pathogenic bacteria has become an important issue in the treatment of animal gastrointestinal diseases, but no safe and effective drug for the treatment of drug-resistant gastrointestinal pathogenic infection has been found yet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The weight percent of each component of the pharmaceutical composition is: 5g of enrofloxacin, 10g of Artemisia argyi leaf extract, 5g of sodium bicarbonate, and 80g of glucose.

[0033] Preparation method: (1) Decoct Artemisia argyi leaves with 7 times the mass of water under pressure for 3 hours at a temperature of 115°C. The purpose of pressurization is to make the water vapor reach the required temperature, and the pressure can be adjusted according to the actual situation; (2) Add absolute ethanol to the decocted water extract until the alcohol content of the mixture is 60%, and then let the mixture stand at 4°C for 12 hours; (3) Filter the mixture after standing to get the supernatant , then heat and concentrate the supernatant to remove water and alcohol, and then dry at a vacuum degree of -0.09MPa and a temperature of 60°C for 0.5-2h to obtain the Artemisia argyi leaf extract; 5g of sodium bicarbonate and 80g of glucose are pulverized through a 40-mesh sieve, an...

Embodiment 2

[0035] The weight percent of each component of the pharmaceutical composition is: 5g of enrofloxacin, 5g of mugwort leaf extract, 5g of citric acid and 85g of soluble starch.

[0036] Preparation method: (1) Decoct Artemisia argyi leaves with 7 times the mass of water under pressure for 3 hours at a temperature of 115°C. The purpose of pressurization is to make the water vapor reach the required temperature, and the pressure can be adjusted according to the actual situation; (2) Add absolute ethanol to the decocted water extract until the alcohol content of the mixture is 60%, and then let the mixture stand at 4°C for 12 hours; (3) Filter the mixture after standing to get the supernatant , then heat and concentrate the supernatant to remove water and alcohol, and then dry at a vacuum degree of -0.09MPa and a temperature of 60°C for 1-2h to obtain the Artemisia argyi leaf extract; 5 g of citric acid and 85 g of soluble starch are pulverized through a 40-mesh sieve, and mixed un...

Embodiment 3

[0038] The weight percent of each component of the pharmaceutical composition is: 2.5g of enrofloxacin, 20g of mugwort leaf extract, 5g of nicotinic acid and 72.5g of sucrose.

[0039] The preparation method is the same as in Example 1.

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PUM

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Abstract

The invention discloses an antibacterial medicament for animals. The medicament comprises the following active ingredients in percentage by weight: 1 to 10 percent of enrofloxacin and 5 to 20 percent of wormwood leaf extract prepared by water extraction and alcohol precipitation. The invention also discloses a preparation method for the medicament and application of the medicament in treating medicament-resistant pathogenic bacteria infection in an animal alimentary canal. The enrofloxacin and the wormwood leaf extract are taken as the active ingredients of the medicament, the defect that the enrofloxacin is easy to generate medicament resistance is overcome and the effect of killing medicament-resistant pathogenic bacteria is greatly improved; the antibacterial medicament has the advantages of reasonable and scientific formula, obviously enhanced antibacterial function of the medicament, obviously improved effect of treating the medicament-resistant pathogenic bacteria infection in the animal alimentary canal, simple and convenient preparation method, and suitability for large-scale production and application.

Description

technical field [0001] The invention relates to an antibacterial drug for animals and its preparation method and application, in particular to a drug for treating animal digestive tract pathogen infection, its preparation method and application, and belongs to the technical field of medicine. Background technique [0002] The survey shows that animal digestive tract diseases can lead to increased animal feeding costs and reduced animal production performance, and are one of the two major diseases that endanger animal breeding. In particular, the digestive tract diseases caused by pathogenic bacteria infection are highly contagious and can cause large groups of animals to become ill, with a high fatality rate, causing huge losses to the aquaculture industry. Commonly used drugs for the treatment of pathogenic bacterial infections in the digestive tract of animals are mainly antibiotics, such as penicillin, cephalosporins, chloramphenicol, aureomycin, berberine, etc., combined...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/282A61P31/04A61P1/00A61K31/496
Inventor 白华刘玉庆谢沄胡明齐静
Owner INST OF ANIMAL SCI & VETERINARY MEDICINE SHANDONG ACADEMY OF AGRI SCI
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