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Oil-in-water furazolidone nano emulsion antibacterial medicament and preparation method thereof

A technology for furazolidone and antibacterial drugs, applied in the field of oil-in-water furazolidone nanoemulsion antibacterial drugs and preparation thereof, can solve the problems of low bioavailability, large toxic and side effects, inconvenient application and the like, and achieves improved solubility and high thermodynamic stability. , the effect of improving bioavailability

Inactive Publication Date: 2012-01-04
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these dosage forms have low bioavailability, large dosage, large toxic and side effects, and inconvenient application.

Method used

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  • Oil-in-water furazolidone nano emulsion antibacterial medicament and preparation method thereof
  • Oil-in-water furazolidone nano emulsion antibacterial medicament and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Accurately weigh 2.0 g of Tween-80, 0.2 g of propylene glycol, 0.2 g of isopropyl myristate, 0.001 g of furazolidone, 0.1 g of dimethylformamide, and distilled water as the balance. Under the condition of 25℃ and room temperature, mix Tween-80, propylene glycol, isopropyl myristate, furazolidone, and dimethylformamide thoroughly with manual stirring as the oil phase, then slowly add distilled water to it, and stir manually while adding , the viscosity of the system is small at the beginning, and as the amount of distilled water increases, the system will become viscous. At this time, the system may appear in a liquid crystal state or a water-in-oil nanoemulsion. Continue to add drops and stir continuously. When the system suddenly becomes thinner, Produced at this time is a stable yellow transparent oil-in-water furazolidone nanoemulsion with a total weight of 10 g.

Embodiment 2

[0052] 3.5 g of RH-40, 0.6 g of ethanol, 0.3 g of propylene glycol, 0.5 g of ethyl acetate, 0.02 g of furazolidone, 0.2 g of dimethylacetamide, and 4.88 g of distilled water.

Embodiment 3

[0054] 2.9 g of EL-40, 1.6 g of ethanol, 0.5 g of triacetin, 0.05 g of furazolidone, 0.75 g of dimethylformamide, and 4.2 g of distilled water.

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Abstract

The invention discloses an oil-in-water furazolidone nano emulsion antibacterial medicament. The diameter of the nano emulsion drops is between 10 and 100 nanometers; and the medicament is prepared from the following raw materials in percentage by mass: 20.00 to 40.00 percent of surfactant, 2.00 to 16.00 percent of cosurfactant, 1.00 to 5.00 percent of oil, 0.01 to 2.00 percent of furazolidone, 1.00 to 12.00 percent of auxiliary material and the balance of distilled water, wherein the mass percentage sum of the raw materials is 100 percent. According to the medicament, the dissolubility of the furazolidone is enhanced, the stability of the medicament is improved, the bioavailability of the furazolidone is improved, the medicament metabolizing time of the furazolidone in vivo is delayed, the consumption of the auxiliary material is reduced, and the production cost is lowered; and the medicament has broad market prospect in the field of medicine.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new drug dosage form of furazolidone, in particular to a transparent and stable oil-in-water type furazolidone nanoemulsion antibacterial drug and a preparation method thereof. Background technique [0002] Furazolidone is a nitrofuran drug commonly used in clinical practice. Its chemical name is 3-(5-nitrofurfural amino)-2-oxazolidinone, also known as furazolidone, yellow powder or crystalline powder, odorless , initially tasteless and then slightly bitter, very slightly soluble in water and ethanol, slightly soluble in chloroform, insoluble in ether, easily soluble in dimethylformamide and nitromethane. This class of drugs has a broad-spectrum antibacterial effect and can kill most Gram-positive bacteria, Gram-negative bacteria, some fungi and protozoa. Low concentration has antibacterial effect, high concentration has bactericidal effect. Among them, the effect on Escherichia coli and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/422A61P31/04A61P31/10A61P33/02
Inventor 欧阳五庆宋冰欧阳伸雨
Owner NORTHWEST A & F UNIV
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