Antibiotic oil-water double suspension type injection emulsion for livestock and preparation method thereof

Abstract

The invention discloses an antibiotic oil-water double suspension type injection emulsion for livestock. The effective antibiotic components of the antibiotic oil-water suspension type injection emulsion are respectively suspended in an oil phase and a water phase, the water phase is in the outer layer and the oil phase is enveloped therein. In the invention, based on the metabolic characteristics of the effective antibiotic components in a target animal body, the effective antibiotic components of the end products of the new preparation are distributed in an equivalent or nonequivalent mode in different oil and water carriers to form the double suspension type emulsion. After the double suspension type emulsion is administered by intramuscular injection, the antibiotics present a split type secondary release characteristic, thus achieving quick acting and long acting combination. The invention has the characteristics that: (1) the preparation process is relatively simple, the materials can be acquired easily, and the preparation process is particularly suitable for large-scale production; (2) medicaments with different amounts of carriers can be designed according to the pharmacokinetic characteristics of different target animals on different antibiotics, thus achieving quick acting and long acting combination and the effect on treating infection, and the medicament is particularly suitable for clinical application; and (3) the carriers of the double suspension type emulsion can carry health raw materials for animals for preparing compound health products for animals.

Description

technical field [0001] The invention relates to a new dosage form of veterinary antibacterial drugs for injection, and also relates to a preparation method of the dosage form. Background technique [0002] At present, in the field of veterinary pharmacy, especially in the field of antibacterial pharmacy, the commonly used dosage forms are several conventional dosage forms such as powder, premix, ordinary water injection, tablet and granule. Such preparations play an important role in controlling animal diseases. played an important role. However, in recent years, animal husbandry diseases have been spreading all over the world, and a vicious cycle of mixed infections has emerged. Conventional drug dosage forms, especially in the field of antibacterial drugs, are difficult to achieve the current purpose of treating bacterial infectious diseases. In recent years, veterinary drug workers have conducted a lot of research on new formulations such as long-acting sustained release...

AI Technical Summary

Problems solved by technology

Due to the metabolic characteristics of the animal body, the effective concentration time of most antibacterial drugs in the body is generally 6-12 hours. Such a half-life increases the number of clinical medications to 2-3 times per day, which brings great difficulties to the actual operation.

In order to change this situation, veterinary medicine workers have concentrated on the development of long-acting sustained-release preparations in recent years, and emphasized the long-acting period, which led to bacterial resistance, drug residues, and long-term retention in the body, resulting in functional effects of certain organs and gene regulation disorders.

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