Method for preparing sulfadoxine
The technology of sulfadoxine and reaction is applied in the field of preparation of sulfonamide antibacterial drugs, which can solve the problems of low yield and unstable quality of finished products, and achieve the effect of improving the purity of finished products.
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0026] The preparation method of sulfadoxine provided by the invention includes methoxidation reaction and product refining.
[0027] The methoxidation reaction is:
Embodiment 2-5
[0028] Add 1200kg of methanol solution with a mass percentage concentration of 98% into the reaction kettle, put in 192kg of flake-shaped solid sodium hydroxide, start stirring, and put in 240kg of 4-(p-aminobenzenesulfonamide)-5-methoxy-6-chloro Pyrimidine, heat up to 75°C, reflux for 6 hours, and the reaction is over; recover methanol to dryness, add 500kg of water to continue to recover above 95°C, and pour the material into the decolorization pot; use 40% glacial acetic acid to adjust the pH Adjust the value to 12, add 3000kg of water, add 40kg of activated carbon, and decolorize at 90°C for 1 hour; Slowly add the glacial acetic acid solution whose mass percent concentration is 40% until the pH value 5.5 is the end point; after stirring and re-testing the pH value is correct, centrifugal dehydration, washing with water, drying and discharging to obtain 285kg of sulfadoxine (crude product), wherein: In the weight ratio of the feed liquid, water and decolorizer, the weight...
Embodiment 2
[0032] The preparation method of sulfadoxine provided by the invention includes methoxidation reaction and product refining.
[0033] The methoxidation reaction is:
[0034] Add 960kg of methanol solution with a mass percentage concentration of 95.5% into the reactor, put in 132kg of granular solid sodium hydroxide, start stirring, and put in 228kg of 4-(p-aminobenzenesulfonyl)-5-methoxy-6-chloro Pyrimidine, heat up to 70°C, reflux for 5 hours, and the reaction is over; recover methanol to dryness, add 500kg of water to continue to recover to above 95°C, put the material into the decolorization pot; use 30% glacial acetic acid to adjust the pH of the reaction solution Adjust the value to 10.5, add 2600kg of water, add 30kg of activated carbon, and decolorize at 80°C for 1 hour; Slowly add glacial acetic acid solution with a mass percentage concentration of 30% at ℃, until the pH value is 5.3 as the end point; after stirring and retesting the pH value is correct, centrif...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com