Filtration-type antimicrobial medicine in-vitro pharmacokinetic/pharmacodynamic model central compartment apparatus

Abstract

The invention belongs to the technical field of pharmacology, and specifically relates to a filtration-type antimicrobial medicine in-vitro pharmacokinetic / pharmacodynamic model central compartment apparatus. The central compartment apparatus mainly comprises a cup cylinder, a suspended stirring apparatus, and a base holder. The cup cylinder is a main structure forming a central compartment cavity. The suspended stirring device is positioned in the cup cylinder. The base holder is arranged under the cup cylinder. The components of the central compartment form an integral whole through internal thread hoops or any other forms. The central compartment is connected with other parts of an in-vitro pharmacokinetic / pharmacodynamic model, such that the filtration-type antimicrobial medicine in-vitro pharmacokinetic / pharmacodynamic model apparatus is formed. According to the invention, a suspended stirring mode is adopted; a filter membrane is arranged at the bottom; liquid is discharged from the bottom, such that bacteria are prevented from flowing out of the central compartment. Compared with prior arts, the structure of the central compartment apparatus provided by the invention is greatly simplified, the accuracy and the operability are greatly improved, and antimicrobial medicine in-vitro pharmacokinetic / pharmacodynamic research efficiency can be substantially improved.

Description

technical field [0001] The invention belongs to the technical field of pharmacology, and relates to in vitro pharmacokinetics / pharmacodynamics of antibacterial drugs, in particular to a filter-type antibacterial drug in vitro pharmacokinetics / pharmacodynamics model central chamber device. Background technique [0002] At present, the clinical pharmacology research of antibacterial drugs has generally applied the combination of pharmacokinetic / pharmacodynamic (PK / PD) research technology. The characteristic of this research technology is that it can reveal the metabolic process of antibacterial drugs in vivo. The dynamic relationship between drugs and bacteria reflects the relationship between drugs and bacteria that is closer to the actual situation; the realization of this research technology can be in the form of animal experiments or in vitro models. Compared with antibacterial drug PK / PD research in animals, the research form of in vitro model has the advantages of simpl...

AI Technical Summary

Problems solved by technology

At present, the structural forms of the central chamber that are widely used in the world mainly include dilution type and dialysis type. The dilution type central chamber structure is a primitive central chamber structure. Although its operation is simple, the bacteria in this type of central chamber will grow with time The waste liquid is discharged and lost, which makes the research results biased, and the colony count results need to be corrected by the calculation formula; the dialysis type is loaded with a dialysis device (a hollow fiber dialysis column is common) on the basis of the dilution type, and the bacteria are inoculated in the The external cavity of the dialyzer, the internal cavity of the dialyzer communicate with the diluted central chamber quickly, and finally the drug concentration in the external cavity of the dialyzer and the diluted central chamber change synchronously, and the drug concentration in the central chamber is still achieved by the first-stage dilution technology; the dialysis Compared with the dilution type device, the type device can well avoid the loss of bacteria, but at the same time, the high cost, relatively complicated equipment and operation have become its disadvantages

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