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Method for synthesizing moxifloxacin hydrochloride

A technology of moxifloxacin hydrochloride and its synthesis method, which is applied in the field of organic synthesis and can solve the problems of high cost, reduced selectivity, and low reaction yield

Active Publication Date: 2010-09-01
PORTON FINE CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

As mentioned above, the methods reported in the literature in the past all use non-Boc-protected formula VI compounds as raw materials to synthesize moxifloxacin hydrochloride, which reduces the selectivity of the reaction, makes the reaction yield low and the cost is high

Method used

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  • Method for synthesizing moxifloxacin hydrochloride
  • Method for synthesizing moxifloxacin hydrochloride
  • Method for synthesizing moxifloxacin hydrochloride

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Abstract

The invention relates to a method for synthesizing a broad-spectrum efficient moxifloxacin hydrochloride, which is a quinolone antimicrobial medicament and has a formula below.

Description

technical field The invention relates to an organic synthesis method, in particular to a synthesis method of moxifloxacin hydrochloride. Background technique Moxifloxacin hydrochloride, the chemical name is 1-cyclopropyl-7-(S,S-2,8-diaza-bicyclo[4.3.0]nonan-8-yl)-6- Fluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinoline carboxylic acid hydrochloride is the fourth-generation extended-spectrum quinolone antibacterial drug developed by Bayer Company, which is used to treat patients Adults with upper and lower respiratory tract infections (eg, acute sinusitis, acute exacerbation of chronic bronchitis, community-acquired pneumonia, and skin and soft tissue infections). Moxifloxacin hydrochloride was launched in Germany for the first time in September 1999, and in the United States in December of the same year. Currently, the dosage forms in my country are tablets and injections. Moxifloxacin hydrochloride has good water solubility and can be directly made into injections. At present, ...

Claims

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Application Information

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IPC IPC(8): C07D471/04A61P31/00
Inventor 覃军王广途沈浩
Owner PORTON FINE CHEM
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