New application of ginkgolide B

A technology of ginkgolide and medicine, which is applied in the new application field of ginkgolide B, and can solve the problems of ginkgolide toxicity and unproven effects
CN102018702AInactive Publication Date: 2011-04-20PEKING UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
PEKING UNIV
Publication Date
2011-04-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses application of ginkgolide B to preparation of medicament for preventing and / or treating autosomal dominant polycystic kidney disease. A madin-darby canine kidney (MDCK) vesicle model is used for screening to find that the ginkgolide B inhibits formation and growth of vesicles. An experimental result shows that: the ginkgolide B has an obvious inhibiting effect on the formation and growth of MDCK vesicles and the effect of the ginkgolide B is in dose response relationship; the ginkgolide B has no cytotoxicity to MDCK cells, so that the vesicle inhibiting effect of the ginkgolide B is independent of the cytotoxicity; the ginkgolide B does not obviously induce MDCK cell apoptosis, so that the vesicle inhibiting effect of the ginkgolide B is independent of cell apoptosis promotion of the ginkgolide B; the ginkgolide B can promote the MDCK cells or vesicles to form tubular structures; and the effect is in dose response relationship; and the ginkgolide B has an inhibiting effect on the growth of the embryonic kidney vesicles. The ginkgolide B provides experimental data for development of a specific medicament for preventing and / or treating autosomal dominant polycystic kidney disease.
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Description

technical field

[0001] The invention relates to a new application of ginkgolide B. Background technique

[0002] 1. Chemical characteristics and pharmacological effects of ginkgolide B

[0003] 1. General characteristics of ginkgolide B

[0004] Ginkgolides (ginkgolides) are a kind of terpenoid lactone compound extracted from Ginkgo biloba, including ginkgolides A, B, C, J, K, L and M, and ginkgolides are platelet activating factors (platelet activating factors). factor, PAF) inhibitor, wherein, ginkgolide B (ginkgolideB, GB, the chemical structural formula of ginkgolide B is as figure 1 shown) is the strongest pharmacological activity of ginkgolides (van Beek TA. Ginkgolides and bilobalide: their physical, chromatographic and spectroscopic properties. Bioorg Med Chem, 2005, 13 (17): 5001-12. Vogensen SB, Stromgaard K, Shindou H, et al. Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists. J Med Chem, 2003, 46(4...

Claims

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