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170results about How to "Limited degree" patented technology

Matrix compositions for controlled delivery of drug substances

A novel matrix composition for pharmaceutical use. The matrix composition has been designed so that it is especially suitable in those situation where an improved bioavailability is desired and / or in those situation where a slightly or insoluble active substance is employed. Accordingly, a controlled release pharmaceutical composition for oral use is provided in the form of a coated matrix composition, the matrix composition comprising i) a mixture of a first and a second polymer that have plasticizing properties and which have melting points or melting intervals of a temperature of at the most 200° C., the first polymer being selected from the group consisting of polyethylene glycols and polyethylene oxides, and the second polymer being selected form block copolymer of ethylene oxide and propylene oxide including poly(ethylene-glycol-b-(DL-lactic acid-co-glycolic acid)-b-ethylene glycol (PEG-PLGA PEG), poly((DL-lactic acid-co-glycolic acid)-g-ethylene glycol) (PLGA-g-PEG), poloxamers and polyethylene oxide-polypropylene oxide (PEO-PPO), ii) a therapeutically, prophylactically and / or diagnostically active substance, the matrix composition being provided with a coating having at least one opening exposing at one surface of said matrix, wherein the active substance is released with a substantially zero order release.
Owner:EGALET LTD

Fragrance containing fiber

Described is a fragrance-containing and fragrance-emitting polymeric fiber which optionally contains (i) at least one antimicrobial agent; and (ii) at least one compatible coloring material or color-forming material which is useful in the ascertainment of the exhaustion or substantial reduction of fragrance, produced by either (i) a processing comprising the steps of:(a) co-extruding fragrance and optionally (i) antimicrobial agent and/or (ii) at least one compatible coloring material or color-forming material which is useful for ascertainment of the exhaustion or substantial reduction of fragrance with a thermoplastic polymer to form an extrudate;(b) forming fragrance and (optionally (i) antimicrobial agent and/or (ii) at least one compatible coloring material or color-forming material which is useful for ascertainment of the exhaustion or substantial reduction of fragrance agent)-emitting particles which may or may not be foamed from the extrudate; and(c) extruding a fiber of from about 3 denier up to about 60 denier from the thus-formed particles;or (ii) a process comprising the steps of:(a) forming fragrance-emitting particles, foamed or not foamed, from a mixture of fragrance and thermoplastic polymer; and then(b) extruding a fiber of from about 3 denier up to about 60 denier from the thus-formed particles.
Owner:INTERNATIONAL FLAVORS & FRAGRANCES

Matrix compositions for controlled delivery of drug substances

A novel matrix composition for pharmaceutical use. The matrix composition has been designed so that it is especially suitable in those situation where an improved bioavailability is desired and / or in those situation where a slightly or insoluble active substance is employed. Accordingly, a controlled release pharmaceutical composition for oral use is provided in the form of a coated matrix composition, the matrix composition comprising i) a mixture of a first and a second polymer that have plasticizing properties and which have melting points or melting intervals of a temperature of at the most 200° C., the first polymer being selected from the group consisting of polyethylene glycols and polyethylene oxides, and the second polymer being selected form block copolymer of ethylene oxide and propylene oxide including poly(ethylene-glycol-b-(DL-lactic acid-co-glycolic acid)-b-ethylene glycol (PEG-PLGA PEG), poly((DL-lactic acid-co-glycolic acid)-g-ethylene glycol) (PLGA-g-PEG), poloxamers and polyethylene oxide-polypropylene oxide (PEO-PPO), ii) a therapeutically, prophylactically and / or diagnostically active substance, the matrix composition being provided with a coating having at least one opening exposing at one surface of said matrix, wherein the active substance is released with a substantially zero order release.
Owner:EGALET LTD

Integrated circuit output buffers having control circuits therein that utilize output signal feedback to control pull-up and pull-down time intervals

Integrated circuit output buffers include primary and secondary pull-down transistors and an output signal line electrically coupled to a drain of the primary pull-down transistor and a drain of the secondary pull-down transistor. A preferred control circuit is also provided. The control circuit turns on the primary pull-down transistor during first and second consecutive portions of a pull-down time interval and uses a signal fed back from the output signal line to control the timing of when a gate of the secondary pull-down transistor is electrically connected to a drain of the secondary pull-down transistor during the first portion of the pull-down time interval and also control the timing of when the gate electrode of the secondary pull-down transistor is electrically connected to a source of the secondary pull-down transistor during the second portion of the pull-down time interval. A pull-down portion of the control circuit may include a gate pull-up transistor having a drain electrically connected to the drain of the secondary pull-down transistor and a source electrically connected to a gate of the secondary pull-down transistor, and a gate pull-down transistor having a drain electrically connected to the gate of the secondary pull-down transistor and a source electrically connected to a source of the secondary pull-down transistor. These gate pull-up and pull-down transistors can be utilized to selectively turn on the secondary pull-down transistor during a first leading portion of a pull-down time interval and then turn off the secondary pull-down transistor during a second trailing portion of the pull-down time interval.
Owner:INTEGRATED DEVICE TECH INC
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