The invention discloses a high-yield drought-enduring planting method of Lentinula edodes, comprising the steps of S1, allocating materials; S2, stirring, to be specific, stirring well cotton seed hull, sawdust, wheat bran, corn flour, dried pond sludge, peanut bran, silkworm excrement, straws, bagasse, cassava dregs, perlite, rapeseed cake, conch shell powder, fly ash, and furfural residue for use, adding calcium superphosphate, sugar, a slow-release filler, a water absorption aid and water, heating, stirring for melting, cooling to room temperature, and loading in a polypropylene plastic bag to obtain a mushroom bag; S3, sterilizing; S4, inoculating, to be specific, placing the mushroom bag in an inoculating room, sterilizing with ultraviolet lamps, and inoculating Lentinula edodes; S5, fermenting, to be specific, after inoculation, placing a cultivar in a hash-sign-like pile for spawn running, and culturing until mycelia fully fill the culture bag. The high-yield drought-enduring planting method of Lentinula edodes can prevent drought weather from harming Lentinula edodes and allows the yield and quality of Lentinula edodes to be effectively improved.