Creatine sustained-release preparation and preparation process thereof medication

A technology of sustained-release preparations and creatine, applied in the field of creatine sustained-release preparations and its preparation, and creatine products, which can solve the problems of short half-life, increased burden on the kidneys, and waste, so as to promote muscle growth and avoid increased burden on the liver and kidneys , Improve the effect of absorption rate

Active Publication Date: 2009-06-17
固安康比特体育科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Taking creatine compounds directly, the release rate of creatine is fast, and most of it quickly enters the circulatory system with a sh

Method used

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  • Creatine sustained-release preparation and preparation process thereof medication
  • Creatine sustained-release preparation and preparation process thereof medication
  • Creatine sustained-release preparation and preparation process thereof medication

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 tablet

[0035] Weigh 12kg of creatine monohydrate, 8.5kg of hydroxypropylmethylcellulose, 1kg of methylcellulose, 1.75kg of lactose and 0.15kg of microcrystalline cellulose, and mix them in a mixer.

[0036] An appropriate amount of 20% ethanol solution is added to the above powder and granulated, the wet material is dried, and properly sieved to obtain dry granules.

[0037] The above-mentioned dry granules are mixed with 0.15 kg of magnesium stearate, and compressed in a tablet machine. Each tablet weighs 800mg.

[0038] The obtained sustained-release creatine tablet has a percentage of creatine monohydrate of 51%, and each tablet contains 358 mg of creatine (calculated as creatine).

Embodiment 2

[0039] Example 2 Powder

[0040] Preparation of coating solution: weigh 3.3 kg of emulsion with 20% ethyl cellulose content, add 1.1 kg of water, stir for 0.5 hour, and set aside.

[0041] Weigh 5 kg of creatine ethyl ester and 6 kg of creatine monohydrate, and apply a top spray process in a fluidized bed for coating. (Parameters: Inlet air temperature 40°C, induced air volume 7m 3 / min, atomization pressure 0.2MPa, flow rate 10ml / min, operating time 65min, weight gain 5%)

[0042] The obtained sustained-release creatine powder has a percentage of creatine ethyl ester of 43.2%, a percentage of creatine monohydrate of 51.8%, and each gram of the product contains 0.80 g of creatine (calculated as creatine).

Embodiment 3

[0043] Example 3 Capsules

[0044] Preparation of coating solution: weigh 3.3 kg of emulsion with 20% ethyl cellulose content, add 1.1 kg of water, stir for 0.5 hour, and set aside.

[0045] Weigh 11 kg of creatine monohydrate, and apply a top spray process in a fluidized bed for coating. (Parameters: Inlet air temperature 40°C, induced air volume 3m 3 / min, atomization pressure 0.2MPa, flow rate 3ml / min, operating time 65min, weight gain 5%)

[0046] The above-mentioned granules are packed into capsule shells, and the amount of each granule is 600 mg.

[0047] The obtained sustained-release creatine granules have a percentage of creatine monohydrate of 95%, and each capsule contains 0.50 g of creatine (calculated as creatine).

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PUM

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Abstract

The present invention provides a sustained-release creatine preparation, which comprises 30-95% of creatine compound in weight percent and 5-70% of sustained-release material in weight percent. The creatine sustained-release preparation is executed with sustained-release processing and causes that the creatine is released slowly and continuously in vivo. The absorption rate is increased. Furthermore the gastrointestinal tract reaction caused by the simultaneously releasing of large amount of creatine in the stomach is prevented. The liver-kidney burden increasing caused by the discharging of redundant creatine by liver metabolism and urine is prevented. Compared with the common creatine, the sustained-release creatine has better effect in the aspects of increasing explosive force, promoting the growth of muscle, etc.

Description

technical field [0001] The invention belongs to the field of health food and relates to a creatine product, in particular to a creatine slow-release preparation and a preparation method thereof. Background technique [0002] Creatine is a natural amino acid in the human body, which mainly exists in muscle. In a human body with a body weight of 70kg, the storage capacity of creatine (including free creatine and phosphocreatine) is about 120g. Humans mainly obtain the creatine they need through diet, and meat and fish are good sources of creatine. Creatine combines with phosphoric acid in the body to form creatine phosphate, and the energy stored in the phosphate bond of creatine phosphate can convert ADP into ATP, which is the direct energy supply material for human activities. [0003] Since the early 1990s, a large number of professional and non-professional sports people have recognized the benefits of creatine as a sports nutrition supplement, and its consumption has gro...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61K47/38A61P3/02A23L1/30A23L2/52A23L33/175
Inventor 白厚增焦颖杨则宜贺刚田红梅
Owner 固安康比特体育科技有限公司
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