36 results about "Creatine Monohydrate" patented technology

According to the creatine-monohydrate pectin soft sweets and the preparation method, the low-amidation pectin is innovatively used in the field of the creatine-monohydrate pectin soft sweets through corresponding pretreatment, so that the problems caused by reaction and decomposition of an amphoteric compound, namely creatine monohydrate, in an original high-ester pectin system are solved; meanwhile, the problem that conventional low-amidation pectin cannot be gelatinized during pouring is solved, the low-amidation pectin and the creatine monohydrate are innovatively combined, and a gel system capable of containing a high-concentration creatine monohydrate compound is prepared. And meanwhile, by adopting a sugar-free formula technology, the requirement that sports people need to supplement creatine monohydrate but do not wish to intake sugar is met.

This invention provides a continuous method for preparing high-purity creatine monohydrate, comprising the following steps: a) adding chloroacetic acid aqueous solution dropwise to an aqueous methylamine solution, stirring at room temperature for 2 hours after the addition is complete; b) heating to 50-60°C and holding for 1 hour to remove most of the methylamine, then heating to 95°C to evaporate the methylamine aqueous solution for 1 hour; c) adding sodium hydroxide solution dropwise to the solution from step b) at 95°C, then heating to 105°C and concentrating under reduced pressure for 1.5 hours to approximately half the original volume, obtaining a creatine solution with a concentration of 30%-40%; d) cooling the solution from step c) to 40-60°C and adding a catalyst; e) drying to obtain pure creatine monohydrate. This invention reduces the methylamine equivalent, saving costs, and eliminates the need for purifying creatine for direct use in the next reaction; it can simultaneously lower the system reaction temperature and pH value to inhibit the formation of byproducts dicyandiamide and creatinine, and eliminates the need for debittering agents for purification and debittering, thus saving production costs.

The invention provides a creatine monohydrate synthesis reaction device, and belongs to the technical field of creatine monohydrate production. Comprising a plate-and-frame filter, a filter frame is mounted in the middle of the plate-and-frame filter, and a speed brake is fixedly connected to the bottom of the filter frame; the dip angle scraping assembly is used for being matched with a worker to scrape a filter cake on the filter frame, and the dip angle scraping assembly is connected with the portal frame. By arranging the dip angle scraping assembly, when filter cakes are scraped, a scraper on a speed brake can slowly scrape the filter cakes from bottom to top along a filter frame, and due to the fact that the scraper is designed in an inclined mode, the contact area between the scraper and the filter cakes is small, excessive filter cake residues attached to the scraper can be reduced, and the resistance for cutting into a viscous layer can be greatly reduced; therefore, the filter cake is scraped more easily, the scraping efficiency is improved, the forming capacity of the filter cake is improved, and effective judgment of the NIR moisture meter on the moisture content of the filter cake in the subsequent drying process is facilitated.

The application provides a creatine monohydrate synthesis reaction device and belongs to the technical field of creatine monohydrate production. The device comprises a plate-and-frame filter, a filter frame is installed at the middle position of the plate-and-frame filter, and a deceleration plate is fixedly connected to the bottom of the filter frame. An inclination scraping assembly is used to scrape the filter cake on the filter frame in cooperation with workers, and the inclination scraping assembly is connected with the portal frame. The inclination scraping assembly is provided, and when the filter cake scraping operation is performed, the scraper on the deceleration plate can slowly scrape from bottom to top along the filter frame. Since the scraper is designed to be inclined, the contact area with the filter cake is small, which can not only reduce the excessive filter cake residues adhered to the scraper, but also greatly reduce the resistance of cutting into the viscous layer, so that the filter cake can be scraped more easily, the scraping efficiency is improved, and the forming capacity of the filter cake is improved, which facilitates the effective determination of the NIR moisture meter on the filter cake moisture content in the subsequent drying process.

The invention discloses a biosynthesis process of creatine monohydrate, and belongs to the technical field of bioengineering. The invention discloses a creatine monohydrate biosynthesis method, which is characterized in that sarcosine invertase is utilized to catalyze chloroacetic acid and monomethylamine to generate N-alkylation reaction so as to prepare sarcosine, and then creatine monohydrate is generated under the catalysis of the creatine invertase, the process is mild in reaction condition, the temperature is 25-37 DEG C, the pH is 6.0-8.0, the energy consumption is lower, the conversion efficiency is high, the environment is protected, and the economical efficiency is high. The invention provides a new synthesis method for sustainable synthesis of creatine monohydrate, and provides a new idea for industrial production of creatine monohydrate.

The invention belongs to the technical field of nutritional supplements, and particularly relates to a novel nutritional composition and application thereof. Comprising creatine monohydrate and a Chinese wolfberry extract, and the weight ratio of the creatine monohydrate to the Chinese wolfberry extract is (0.5: 1)-(3: 1). Experiments find that after a human body takes the nutritional composition, the content of phosphocreatine PCr in muscles can be increased by 14%-19%, the 1-RM strength can be increased by 6.1%-8.5%, and it is indicated that the nutritional composition has the effect of improving the functional muscle strength and the phosphocreatine level. And the effect generated by the nutritional composition is far beyond the sum of the independent effects of all the components, so that the combination of the creatine monohydrate and the wolfberry extract has an unexpected and non-obvious synergistic effect in the aspects of improving the functional muscle strength and the creatine phosphate level.

The invention provides a method for analyzing a creatine monohydrate molecule hydrogen bond network and a vibration mode based on a terahertz spectrum. The method comprises the following steps: carrying out terahertz spectrum measurement on a creatine monohydrate sample at different temperatures (for example, the temperature is reduced from 300 K to 4.5 K) to obtain absorption spectrum data in a wave band of 1-14 THz; analyzing the spectral data, and dividing the absorption peaks according to a characteristic frequency of about 9.95 THz: defining the absorption peaks lower than the frequency as a hydrogen bond network vibration region, and defining the absorption peaks higher than the frequency as an intramolecular vibration region; the crystal structure of creatine monohydrate and the stability of the hydrogen bond network are evaluated and identified by observing a blue shift phenomenon of an absorption peak of a vibration area of the hydrogen bond network along with temperature reduction and local vibration characteristic peaks appearing at 6.58 THz and 7.97 THz at a specific temperature (such as lower than 200K). According to the method, a technical means for directly and nondestructively representing the dynamic characteristics of the creatine monohydrate crystal lattice is provided by establishing the corresponding relation among the temperature, the frequency and the vibration mode.

The invention relates to the technical field of creatine monohydrate production, in particular to a creatine monohydrate conveying and feeding device for creatine monohydrate food processing.The creatine monohydrate conveying and feeding device comprises a bearing base and a feeding assembly, and the feeding assembly comprises a height adjusting piece, a connecting base, a feeding hopper, a material guiding frame, a screening piece, two spiral feeding rods, two transmission shafts and a driving mechanism; a creatine monohydrate raw material is put into the feeding hopper, then impurity screening is conducted on the creatine monohydrate raw material through the screening piece, the creatine monohydrate raw material is dispersed in the screening process and then falls into the feeding hopper, the driving mechanism is controlled to drive the two transmission shafts to drive the two spiral feeding rods to rotate, and then the creatine monohydrate raw material is fed into the feeding hopper through the two rotating spiral feeding rods. And the screened creatine monohydrate raw material is dispersed and thrown out through the material guiding frame, so that the problem that the follow-up processing efficiency is poor due to the fact that the raw material is not dispersed in the feeding process of an existing feeding device and is excessively concentrated when being thrown into processing equipment is solved.

The utility model relates to the technical field of chemical engineering systems, in particular to a creatine monohydrate production system which comprises a creatine monohydrate separation device and a first polymer filter membrane device, the creatine monohydrate separation device is provided with a mother liquor discharge pipe, and the mother liquor discharge pipe is connected with an inlet of the first polymer filter membrane device. And the first polymer filtering membrane device is provided with a second byproduct discharging pipe and a circulating material discharging pipe. By-products filtered by the first polymer filtering membrane device are conveyed to a fertilizer production system through a second by-product discharging pipe to produce organic nitrogen fertilizer, the by-products are recycled, waste liquid discharge is reduced, and economic benefits are improved. The filtrate is conveyed to the creatine monohydrate reaction kettle through the circulating material discharging pipe to continue to participate in the reaction, so that the utilization rate of methylaminoacetonitrile, sodium sarcosinate and part of creatine monohydrate in the filtrate can be increased, and raw materials are saved.

The utility model relates to the technical field of solution purification, and discloses a creatine monohydrate purification device capable of recycling mother liquor, which comprises a heat preservation enamel kettle shell, a stirring enamel kettle shell is fixedly connected in the heat preservation enamel kettle shell, and a driving end of a driving component is fixedly connected with a working gear I; a connecting shaft is rotatably connected to the interior of the gear protection block, a first transmission gear is fixedly connected to the exterior of the connecting shaft, a forward stirring shaft is fixedly connected to the interior of the first transmission gear, and a reverse stirring shaft is rotatably connected to the exterior of the forward stirring shaft. According to the utility model, the rotating motor is started to drive the working gear I, the working gear I drives the transmission gear I to rotate through the internal gear ring which is externally coupled and connected, then the transmission gear II which is connected with the bottom of the connecting shaft drives the working gear II to rotate, then the working gear II drives the forward stirring shaft, and the stirring fan blades are matched with the kettle bottom stirring block; and the solution is fully stirred.

This invention belongs to the field of organic synthesis technology, specifically relating to a creatine glycinate and its preparation method, comprising the following steps: pretreatment, drying creatine monohydrate, passing glycine through a 100-mesh sieve and storing it in a desiccator for later use, and selecting a reaction solvent; raw material dissolution, adding the reaction solvent to a reaction vessel, starting stirring and heating, adding creatine monohydrate, and stirring at a constant temperature until completely dissolved, finally obtaining a creatine solution; complexation reaction, adding glycine, increasing the stirring rate and heating after the addition is complete, maintaining the temperature for the complexation reaction, using staged stirring until the complexation reaction is complete; after the reaction is complete, using a gradient cooling method; crystallization and ripening, followed by constant temperature and low-speed stirring for 2 hours, then allowing the crystals to settle completely; after filtration, vacuum drying is performed to finally obtain creatine glycinate. This application solves the problems of uneven reaction, poor crystal quality, and low purity and yield in existing processes, achieving efficient and high-quality preparation of creatine glycinate.

This invention belongs to the field of organic synthesis technology, specifically relating to creatine nitrate and its preparation method, including the following steps: raw material pretreatment, pretreating creatine monohydrate; adding 600g of reaction solvent to a reaction vessel, stirring, adding 150g of purified creatine monohydrate from step 100, mixing evenly to obtain a reaction solution, and heating to 50-55℃; slowly adding 110g of 65% nitric acid dropwise to below the surface of the reaction solution, and after the addition is complete, maintaining the temperature at 50-55℃ for 2 hours to obtain a mixed solution; cooling the mixed solution to 0-5℃ at a cooling rate, adjusting the stirring rate, and stirring at a constant temperature for 2 hours to crystallize; filtering the above crystallization system, washing the filter cake 2-3 times with a cold solvent at 0-5℃; vacuum drying the filter cake, and sieving after drying to obtain the creatine nitrate product. This invention achieves efficient and stable preparation of creatine nitrate, significantly improving product yield and purity.

The utility model relates to the technical field of food processing, and discloses a granularity-adjustable creatine monohydrate special crusher which comprises a bottom plate, the top of the bottom plate is fixedly connected with a first supporting plate, the front side of the first supporting plate is fixedly connected with a fixing plate, the inner side of the first supporting plate is fixedly connected with a granularity-adjustable crushing mechanism, and the top of the bottom plate is fixedly connected with a second supporting plate. A first supporting plate is fixedly connected to the top of the fixing plate, a second supporting plate is fixedly connected to the top of the first supporting plate, a smashing pretreatment mechanism is fixedly connected to the inner side of the second supporting plate, the smashing mechanism comprises a smashing machine shell, the outer side of the smashing machine shell is fixedly connected to the inner side of the first supporting plate, and a driving assembly is fixedly connected to the top of the fixing plate. According to the creatine monohydrate crusher, the two connecting rods slide in the grooves formed in the connecting strips and the grooves formed in the crusher shell, the angle of the baffle is adjusted, the granularity of the crushed creatine monohydrate can be accurately controlled according to requirements, and the crusher can adapt to diversified production requirements.

The invention belongs to the technical field of nutritional supplements, and particularly relates to a nutritional supplement with stable performance and application thereof. The nutritional components comprise creatine monohydrate and a Chinese wolfberry fruit extract. Under a buffer system, the creatine monohydrate and the wolfberry extract in the nutritional supplement are mixed according to a ratio of (0.5-5): 1, so that the PCr and 1-RM power can be effectively improved, the decomposition of creatine can be greatly reduced, and a positive effect on maintaining active creatine is achieved. Experiments show that according to the nutritional composition, the increase amount of PCr is 14%-19%, the increase amount of 1-RM power is 6.1%-8.5%, the highest percentage of residual creatine can reach 94%-95%, and the content of active creatine is reserved to a great extent.

The invention relates to the technical field of creatine monohydrate preparation, and discloses a creatine monohydrate synthesis preparation method and equipment, and the method comprises the following steps: S1, adding chloroacetic acid and methylamine water into a reaction kettle, and carrying out a reaction at 20-30 DEG C for 8-10 h; s2, the temperature is raised to 80-95 DEG C, the heating time is 1-3 h, and unreacted methylamine is recovered; s3, adding a sodium hydroxide solution into the solution obtained in S2, and neutralizing reaction by-products; s4, heating to 105-110 DEG C, and concentrating under reduced pressure to obtain a sarcosine aqueous solution; s5, filtering the sarcosine aqueous solution in the step S4, and taking filtrate into a crystallizer; s6, continuously introducing ammonia gas into the crystallizer, stirring, adjusting the pH value of the solution to 9-12, and then performing crystallization treatment on the reaction solution to obtain creatine crystals; and S7, filtering, washing and drying the creatine crystals in the step S6 to obtain crude creatine monohydrate. The method has the following advantages and effects that the reaction efficiency and the conversion rate are relatively high, the produced creatine monohydrate is high in purity and stable in quality, and the requirements of different fields on the product quality can be met.

The present application discloses a method for synthesizing creatine monohydrate from glycine, which includes mixing formaldehyde with an acid solution to obtain an acidic solution, and adjusting the pH of the acidic solution to 3 to 5; reacting the glycine solution with the acidic solution to obtain a reaction solution; reacting the reaction solution with a cyanamide solution to obtain a creatine reaction solution; and performing post-treatment on the creatine reaction solution to obtain creatine monohydrate. In the present application, high-purity creatine monohydrate is obtained under the environment of a low-concentration reaction solution. Compared with the prior art, the steps are simple, thus simplifying the process of synthesizing creatine monohydrate from glycine. Moreover, in this method, the yield of creatine monohydrate is greater than 70%, and the highest yield can reach 83%, improving the yield of creatine monohydrate.

The invention relates to the technical field of nutritional supplements, and discloses a creatine-rich micro-effervescent tablet preparation process, the method comprises raw material pretreatment, wet granulation, fluidized bed embedding granulation, drying treatment and total mixing tabletting, and the creatine raw material (including creatine monohydrate and creatine hydrochloride) pretreatment standard is set, so that the creatine raw material (including creatine monohydrate and creatine hydrochloride) is obtained; and the conversion reference consistency of different batches of creatine raw materials is ensured. By capturing abnormal adhesive distribution signals in the wet granulation process in real time, a hot air supply and exhaust strategy is adjusted in real time, and it is guaranteed that the process balance point is rapidly recovered under the abnormal working condition of the creatine hydrochloride granulation process; meanwhile, a crystal water removal state is synchronously monitored in a fluidized bed embedding granulation link, so that whether a temperature control deviation problem occurs in a creatine monohydrate dehydration process or not can be dynamically identified, the stability of converting creatine monohydrate into anhydrous creatine is guaranteed, and the process fluctuation risk of disintegration time limit of the effervescent tablets is reduced from the source.

Provided herein is an exercise supporting nutritional supplement with an associated delivery platform, method, and system. As disclosed the exercise supporting nutritional supplement may comprise some or all of Agmatine Sulfate, Betaine Anhydrous, Choline (as Choline Bitartrate), Citrulline, Creatine Monohydrate, Beta Alanine, L-Tyrosine, Choline Bitartrate, Bovine Collagen, Caffeine Anhydrous, Pink Himalayan Salt, and Black Pepper Extract.

The utility model relates to the technical field of stirrers, and discloses a creatine monohydrate crystal processing device capable of accurately controlling temperature, which comprises a box body, a sliding sleeve is fixedly connected to the inner wall of the box body, two fixing blocks are fixedly connected to the outer part of the sliding sleeve, a sliding ball is rotatably connected to the inner wall of the sliding sleeve, and the sliding ball is fixedly connected to the inner wall of the box body. The end, away from the fixing block, of the sliding ball is fixedly connected with a rotating column, the outer portion of the rotating column is movably connected with a clamping sleeve, the inner wall of the clamping sleeve is movably connected with a first clamping ring, the end, away from the rotating column, of the clamping sleeve is fixedly connected with a fixing ring, and the end, away from the first clamping ring, of the clamping sleeve is movably connected with a second clamping ring. The motor drives the rotating column to rotate, the rotating column extrudes the clamping sleeve, the clamping sleeve is connected with the fixing ring, and the first clamping ring and the fixing ring deform to apply pressure to the fixing ring, so that the internal sealing effect is improved, the rotating column is stabilized, and the abrasion degree of the rotating column is reduced.

The dialysis solution is used in the prophylaxis and treatment of creatine deficiency in patients and comprises one or more creatine compound(s) selected from the following groups: (i) (phospho)creatine and the physiologically acceptable salts thereof, in each case together with any desired proportions of water of crystallization, in particular creatine monohydrate; and (ii) guanidinoacetic acid (physiological precursor of creatine) and the physiologically acceptable salts thereof, in each case together with any desired proportions of water of crystallization. The one or more creatine compound(s) is / are present in the dialysis solution in a concentration equivalent to 0.8 to 2.5 mM creatine. The dialysis solution additionally has a concentration of 0.1 to 200 μpM creatinine.

The invention provides a creatine compound B vitamin composition and a preparation method thereof. The creatine compound B vitamin composition is prepared from the following raw materials in parts by weight: 50 to 70 parts of creatine monohydrate, 4 to 20 parts of compound B vitamin microcapsules, 15 to 40 parts of silicified microcrystalline cellulose (SMCC) and 0.5 to 1.5 parts of magnesium stearate. The creatine and the vitamins play a synergistic role, the compatibility and the stability of all the components are remarkably improved by optimizing the composition and the proportion of the raw materials and combining a special preparation process, and the bioavailability of the creatine is improved. The composition provided by the invention can effectively improve athletic performance, promote muscle recovery and meet nutritional requirements of different people.

The invention provides a method for preparing high-content creatine monohydrate. The method comprises the following steps: continuously preparing a sarcosine aqueous solution from a sodium sarcosine aqueous solution through bipolar membrane electrodialysis, and then carrying out continuous scraper evaporation concentration to obtain a sarcosine concentrated solution; the method comprises the following steps: respectively introducing a sarcosine concentrated solution, a cyanamide (IV) aqueous solution and an additive into a continuous kettle, carrying out guanidination reaction, and then carrying out cooling crystallization, centrifugation, washing and drying to obtain creatine monohydrate; the additive is one or a combination of more than two of sodium decyl sulfate, sodium dodecyl sulfate, sodium hexadecyl sulfate, sodium octadecyl sulfate or sodium octadecyl sulfonate. The method has the advantages of high automation degree, simple operation, easy realization and control of reaction conditions, low energy consumption, low cost, avoidance of generation of sodium chloride waste salt, safety and environmental protection; the obtained creatine monohydrate has the advantages of high yield, high purity, uniform particles, good fluidity and difficulty in caking.

The application provides a high-stability creatine monohydrate composition and a preparation method thereof, and comprises core material and coating material; the core material comprises modified silicon dioxide 10-50 parts, creatine monohydrate 1-5 parts, a filler 10-50 parts and a binder 1-5 parts; the coating material comprises polyacrylic resin II 1-10 parts and a film-forming aid 1-20 parts; wherein the modified silicon dioxide is a product of KH570 grafted silicon dioxide and copolymerization of methacryloxypropyl double-terminated polydimethylsiloxane. The added modified silicon dioxide has a super large specific surface area, can firmly adsorb creatine monohydrate on the surface and enhance the stability of creatine monohydrate; meanwhile, through copolymerization with methacryloxypropyl double-terminated polydimethylsiloxane, the modified silicon dioxide forms a stable three-dimensional network structure of organic silicon, can wrap the adsorbed creatine monohydrate inside and further enhance the stability of creatine monohydrate.

The invention discloses functional soft sweets with creatine and a preparation method of the functional soft sweets, the soft sweets comprise 20 to 35 parts of deionized water, 40 to 65 parts of maltitol liquid, 20 to 30 parts of creatine monohydrate, 8 to 15 parts of white granulated sugar, 0.5 to 1 part of sodium citrate, 1 to 3 parts of compound stabilizer, 0.01 to 0.03 part of stevioside, 0.1 to 0.8 part of acid liquor, 0.01 to 0.07 part of food coloring and 0.1 to 0.5 part of edible essence, the creatine monohydrate is subjected to superfine grinding, and the particle size D90 of the creatine monohydrate is less than or equal to 20 microns. The soft sweets are compounded by the maltitol liquid, the white granulated sugar, the stevioside, the creatine monohydrate and other components, so that the soft sweets have the following characteristics that the soft sweets are soft and glutinous in mouth feel and moderate in sweetness, have sour and sweet flavor, and contain rich creatine and other functional components; the requirements of fitness people and people paying attention to health on energy supplement, muscle recovery, immunity improvement and the like can be met.

This invention provides a creatine citrate and its preparation method. In this method, creatine monohydrate is used as the creatine source, and creatine monohydrate reacts with citric acid in a reaction solvent. The creatine citrate is obtained through temperature-controlled reaction, temperature-controlled crystallization, filtration, and drying. The product obtained by this invention has a molar yield ≥90% and a purity ≥99.6%. The obtained creatine citrate is a white crystalline powder and can be widely used in food and beverage additives, health products, pharmaceutical raw materials, daily chemical raw materials, and feed and veterinary drug additives.

The application provides a method for reducing the content of trace and trace impurities in creatine monohydrate, and relates to the technical field of chemical production.The method provided by the application reduces the content of trace and trace impurities in creatine monohydrate by inhibiting side reactions through a catalyst and reducing the content of trace and trace impurities in creatine monohydrate through recrystallization technology.The catalyst can not only catalyze the formation of non-radical to inhibit the generation of dicyandiamide from cyanamide radical, but also catalyze the oxidation of trace formaldehyde in sodium creatine to inhibit the generation of dihydrotriazine, and finally high-purity creatine monohydrate product can be produced through recrystallization.The content of dicyandiamide and creatinine in creatine monohydrate produced by the prior art is 300-400 mg·kg ‑1 , the content of dihydrotriazine is 20-30 mg·kg ‑1 , and these impurities are harmful to human body, so it is difficult to further reduce them by the prior art.The method provided by the application can reduce the content of dicyandiamide and creatinine in creatine to less than 50 mg·kg ‑1 , and the content of dihydrotriazine is reduced to less than 5 mg·kg ‑1 .

Provided herein are compositions and methods of using the same for effectively increasing NAD levels in a subject in need thereof and improving body function associated with low NAD levels. The compositions comprise an NAD precursor and additional components that increase NAD levels and improve mitochondrial and cellular function. The additional components include NAD +, NADH, D-ribose and creatine monohydrate, nicotinamide and / or nicotinic acid (NA), and can be added to a formulation to further enhance the efficacy of the composition.

The invention relates to the technical field of functional food, in particular to a preparation method of an ultramicro creatine flash-soluble composition, the composition and application. The method comprises the following steps: crushing creatine monohydrate and carrying out static elimination treatment to obtain superfine creatine; zinc glycinate and magnesium glycinate are mixed, spray coating is performed to form microcapsules, and the zinc-magnesium amino acid chelate is obtained; carrying out dry mixing on the superfine creatine and the zinc-magnesium amino acid chelate, spraying a mixed solution of sodium alginate and fruit powder, and carrying out freeze drying to form a porous embedding structure, so as to obtain the superfine creatine zinc-magnesium compound; and uniformly mixing the embedded superfine creatine zinc-magnesium compound with erythritol and xylitol, and carrying out ultraviolet sterilization to obtain the superfine creatine flash-soluble composition. The bioavailability of creatine is effectively improved, and the generation of creatinine is reduced, so that the liver and kidney metabolism burden is reduced. Meanwhile, the addition amount and the existence form of the magnesium element are reasonably controlled, the diarrhea problem caused by large dosage of magnesium is avoided, and the safety and the effectiveness of the sports nutritional supplement are improved.

The invention belongs to the technical field of nutritional supplement chemical and chemical synthesis, and particularly relates to a creatine magnesium chelate and a preparation method and application thereof, and the preparation method comprises the steps of reaction solution preparation, mixing, chelation reaction, thermal microfiltration, anti-solvent crystallization, centrifugal recovery and vacuum drying. The method comprises the following steps: carrying out a low-temperature equimolar chelation reaction on creatine monohydrate and a specific magnesium salt under the conditions that the pH value is 7.0-8.0 and the temperature is 25-40 DEG C, carrying out thermal microfiltration on a solution after the reaction is completed through a microfiltration column, then cooling a filtered solution to 5-10 DEG C, carrying out an ethanol and acetone binary anti-solvent low-temperature precipitation purification process, centrifugally collecting crystals, and carrying out vacuum drying, so that the product purity is more than or equal to 98%, the yield is more than or equal to 85%, and the product purity is more than or equal to 90%. The obtained product shows a stable coordination structure, and is especially suitable for the production of sports nutritional supplements and medical magnesium supplements.

The invention discloses synthesis and application of a modified creatine monohydrate antibacterial surfactant, and belongs to the technical field of daily chemical products. The modified creatine monohydrate antibacterial surfactant is a symmetrical dicationic amphiphilic surfactant formed by a quaternization modified creatine dicationic structure through a connecting arm; and the connecting arm is obtained by reaction of hydroxyethyl ethylenediamine and glutaryl dichloride. According to the modified creatine monohydrate antibacterial surfactant, creatine molecules of natural sources serve as a structural framework, the antibacterial function and the surface activity are integrated through chemical modification, and the modified creatine monohydrate antibacterial surfactant is suitable for being applied to the fields of medical disinfection, daily chemical washing and care, biological materials and the like.