53 results about "Creatine Monohydrate" patented technology

The present invention provides methods of treating neurological disorders, such as Huntington's disease, Parkinson's disease and amyotrophic lateral sclerosis, by administering creatine monohydrate and dextrose, alone or in combination with an anti-inflammatory compound, to a subject.

The present invention relates to the use of creatine compounds, such as, for example, creatine monohydrate, creatine pyruvate and creatine ascorbate, for the treatment of skin.

The feed additive is characterized by that said feed additive is a mixture of pyruvate and creatine monohydrate, in which the content of pyruvate is 55-75 wt%. The can raise thin-meat rate in animal body obvious, and has no harmful substance, is safe for human body.

The invention provides a tin alloy electroplating solution. The tin alloy electroplating solution comprises organic mixed acid, organic tin salt, organic metal salt, complexing agents, reducing agents, stabilizing agents, refining agents, brightening agents and deionized water. The tin alloy electroplating solution comprises, by weight, 1000 parts of deionized water, 100-600 parts of organic mixedacid, 40-100 parts of organic tin salt, 1-8 parts of organic metal salt, 50-160 parts of complexing agents, 30-70 parts of reducing agents, 20-100 parts of stabilizing agents, 5-20 parts of refiningagents and 3-15 parts of brightening agents. The organic metal salt comprises one of organic silver salt, organic copper salt and organic bismuth salt. The complexing agents comprise one or more of thiourea, 1,3-dimethylthiourea, 2,4-dithiobiuret, 2,4,6-trithio-triuret, 2,2-dithiodipyridine, 2,2-dithio-aniline, tetramethyl guanidine, guanidinoacetic acid, creatine monohydrate and sulphydryl chitosan.

The invention provides a ribose functional food. The ribose functional food comprises the following components in parts by weight: 30-70 parts of the D-ribose, 10-60 parts of the L-propionylcarnitine, 0.02-10 parts of the L-malic acid, 0.17-0.5 parts of the coenzyme Q10 and 5-20 parts of the maltodextrin which are taken as main raw materials; one or more of magnesium gluconate, calcium gluconate, selenomethionine, taurine, creatine monohydrate, NADH (NicotinamideAdenine Dinucleotide), glutamine, glycine, spices and edible pigments are selected as auxiliary materials to be mixed to prepare oral preparations including tablets, capsules, granules and oral solutions. The invention provides the functional food capable of increasing the energy in the body, accelerating the recovery of fatigue, increasing the myocardium energy, reducing the oxygen consumption amount and accelerating the recovery of an organism aiming at people who are occupied in high-strength physical exercise or heavy physical labor, coronary heart disease prognostic patients, old people and patients of some chronic diseases.

The invention discloses a preparation method for creatine nitrate. The preparation method comprises the following steps: adding water and creatine monohydrate into a reaction container, and stirring and mixing at a temperature lower than 20 DEG C; then, adding nitric acid into the reaction container and controlling the reaction temperature to be lower than 40 DEG C, filtering reaction liquor after the reaction liquor is clarified, cooling the filtered reaction liquor to be lower than 5 DEG C within 0.5-1.5 hours under stirring, standing for 0.5-1.5 hours, centrifuging to separate out mother liquor and creatine nitrate wet crystals; drying the creatine nitrate wet crystals for 5-7 hours under reduced pressure at a temperature lower than 55 DEG C to obtain the creatine nitrate, and replacing mother liquor with water as raw materials for producing next batch of the creatine nitrate. According to the preparation method disclosed by the invention, the creatine nitrate with purity of 99.8% and creatinine lower than 30PPM and without creatine dinitrate and trinitrate can be obtained without re-crystallization, the yield of the creatine nitrate is higher than 83.8%, the energy consumption is reduced, and the cost is low. The whole preparation process is environmentally friendly.

Compositions for neuroprotection and treatment of neurodegeneration and methods of administering same. In particular, the present invention relates to compositions and methods for preventing or reducing neurodegeneration, such as neurodegeneration caused by Huntington's disease, including administering a daily dose of a composition including an effective amount of creatine hydrochloride to a patient in need thereof. The methods of the present invention allow for lower dosages of supplementation as compared to creatine monohydrate while retaining all of the desired biological effects of creatine supplementation.

The invention relates to a feed additive for enhancing immunity of yellow catfish, which is prepared from, by weight, 5-8 parts of L-lysine, 1-3 parts of magnesium acetate, 1-3 parts of organic selenium, 1-3 parts of trehalose, 2-5 parts of taurine, 5-8 parts of calcium pantothenate, 8-12 parts of creatine monohydrate, 5-8 parts of L-citrulline, 3-6 parts of sodium propionate, 2-5 parts of zinc gluconate, 5-8 parts of calcium hydrophosphate, 3-6 parts of calcium glycinate, 3-6 parts of pyridoxamine, 2-5 parts of folic acid, 2-5 parts of choline chloride, 5-8 parts of betaine, 2-4 parts of dimethyl-beta-propiothetin, 2-5 parts of sodium chloride, 2-5 parts of inositol, 1-3 parts of vitamin A, 1-3 parts of vitamin B, 5-8 parts of vitamin C, and 2-5 parts of vitamin E. The feed additive can effectively improve the diseases prevention and resistance effect of the yellow catfish and can enhance immunity.

The invention discloses natural functional beverage composition capable of improving efficiency during movement training and application of the natural functional beverage composition. The natural functional beverage composition comprises the following components in parts by weight: 300-650 parts of soybean and potato isolated protein, 50-150 parts of branched chain amino acids, 300-650 parts of black kernelled rice and black kernelled rice starch, 60-200 parts of a beetroot extract, 50-150 parts of an agave extract, 1-20 parts of a rhodiola root extract, 10-50 parts of an organic apple skin extract, 50-150 parts of creatine monohydrate, 20-80 parts of taurine, 10-70 parts of coconut milk freeze-dried powder, 1-10 parts of a beet leaf extract, 0.1-2 parts of vitamin B1, 1-12 parts of magnesium aminosuccinate, 20-80 parts of natural spices containing soybean lecithin, 1-8 parts of sodium chloride, and 0.1-2 parts of potassium chloride. The composition can improve the antioxidation level and the aerobic metabolism level of organisms, improves the oxygen utilization efficiency of cells, and contributes to rapid improvement of movement performance and the efficiency of organisms.

The invention discloses a preparation method of guanidine derivative creatine hydrochloride, belonging to the technical field of additives. The method adopts a key technology of 'enabling materials to be recyclable and reusable without three wastes by strictly controlling moderate reaction temperature and corresponding conditions'; creatine monohydrate is taken as a material and thionyl chloride is adopted for acidolysis; the creatine monohydrate and the thionyl chloride are subjected to acidolysis salification; filtrate solution after filtering the acidolysis-salified acidolysis solution is subjected to vacuum reduced-pressure distillation and concentration and then standing crystallization is conducted; the standing crystallized substance is washed under the state of solvent extraction filtration; and the washed standing crystallized substance is dried until the water content lowers to below 1%, therefore the guanidine derivative creatine hydrochloride product is obtained. The preparation method is used for the additives in foods and various beverages. The preparation method is scientific and reasonable, simple and feasible to operate, stable and reliable in effect, high in product purity, good in quality and low in cost, and causes no pollution without the three wastes.

A creatine amidinohydrolase having the following physicochemical properties: Action: catalyzing the following reaction; creatine + H2O -> sarcosine + urea Optimum temperature: about 40 - 50 DEG C Optimum pH: pH about 8.0 - 9.0 Heat stability: not more than about 50 DEG C (pH 7.5, 30 min) Km value for creatine in a coupling assay using a sarcosine oxidase and a peroxidase: about 3.5 - 10.0 mM Molecular weight: about 43,000 (SDS-PAGE) Isoelectric point: about 3.5, a method for producing said enzyme, comprising culture of microorganism producing said enzyme, a method for the determination of creatine or creatinine in a sample using said enzyme, and a reagent therefor. According to the present invention, a creatine amidinohydrolase having a smaller Km value than that of the conventionally known creatine amidinohydrolase can be produced in an industrially large amount, and can be used as a routine reagent for clinical tests for determining creatine and creatinine in biological samples.

The invention relates to the field of feed processing and manufacturing, and discloses a feed additive for increasing the lean meat percentage of pork. The feed additive comprises additives A and additives B. The additives A comprise Chinese herbal medicine mixed preparations, betaine, creatine monohydrate, glycocyamine, adenosine triphosphate, mixed vitamins and dopamine; the additives B comprise Chinese herbal medicine mixed preparations, amino acid, creatine monohydrate, carnitine, dihydropyridine, mixed vitamins and dopamine. The feed additive has the advantages that pigs are high in growth speed when the additives A are applied to breeding the pigs with the weights of 20-50 kilograms, the skeletal development of the pigs can be promoted by the additives A, the back-fat thickness can be reduced, and spaces can be provided for muscular synthesis; fat deposition can be accelerated when the additives B are used for breeding pigs heavier than 50 kilograms, and the deposition speeds of proteins can be increased by the additives B by means of constraints on the growth intensity of fat tissues.

The invention relates to a recovery sport nutrition food formula. The food formula includes 40-60% of glucose, 12-18% of L-glutamine, 2-10% of white granulated sugar, banana meal, 2-8% of collagen peptide, 3-5% of creatine monohydrate, 4-10% of trehalose, citric acid, 1-2% of taurine, 0.5-4% of banana flavored essence, 0.3-0.6% of magnesium oxide, potassium chloride, 0.1-0.5% of vitamin C, sucralose, 0.01-0.03% of nicotinamide, 0.004-0.007% of calcium pantothenate, 0.001-0.005% of vitamin B1, 0.001-0.005% of vitamin B2, 0.001-0.005% of vitamin B6 and 0.000005-0.000008% of vitamin B12. The foodformula fully considers that muscle needs sugar (i.e. carbohydrate, an energy substance required after long-time exercise) after exercise and also needs to recover the energy substance, such as the creatine monohydrate, required by short-term explosive exercise.

The invention discloses a creatine instant powder and a preparation method thereof. The creatine instant powder comprises the following components in percentage by mass: 18-40% of creatine monohydrate, 0-40% of instant additive, 0.4%-2% of a suspension stability additive, 20-60% of a spray drying additive and the balance of moisture. The obtained high load creatine instant powder can be rapidly dispersed into water; the concentration of the suspension creatine monohydrate reaches 3-10 times of the saturated solubility thereof; meanwhile, the solution after redissolving can keep stable within 24 hours, and is not layered.

A process for the preparation of creatine or creatine monohydrate by reaction of sodium or potassium sarcosinate with cyanamide at a temperature from 20 to 150° C. and a pH from 7.0 to 14.0 comprises carrying out the pH adjustment with carbonic acid.

The invention discloses a high-energy solid beverage used during sports. The high-energy solid beverage comprises the following raw materials in percentage by weight of maltooligosaccharides, cane sugar, oral glucose, sodium chloride, vitamin B6, vitamin B12, vitamin C, creatine monohydrate, glutamine, branched chain amino acids, gamma-aminobutyric acid, fruit and vegetable ferment powder, and bacteria-free water. A preparation method of the high-energy solid beverage comprises the following steps of S1, weighing the raw material components; S2, dissolving the raw material components, and performing stirring to obtain mixed liquid A; S3, adding the branched chain amino acids and the gamma-aminobutyric acid to the mixed liquid, and performing uniform stirring to obtain mixed liquid B for standby application; S4, putting the mixed liquid in gel powder; and S5, subpacking 40g of the granular solid beverage to each of bags so as to obtain the high-energy solid beverage. The prepared high-energy solid beverage is small in size and high in energy, can provide nutrient substances of sugar, electrolyte, vitamins, protein, amino acids and the like which are easy to absorb by human bodies, and can rapidly allay tiredness and restore physical strength.

The invention discloses a grape-flavor composite creatine and a preparation method thereof. The grape-flavor composite creatine is prepared from the following raw materials: 32-36 parts of creatine monohydrate, 12-18 parts of beta-alanine, 13-18 parts of L-arginine, 2-5 parts of 1,6-fructose diphosphate, 5-8 parts of taurine, 0.2-0.5 part of niacin, 0.1-0.3 part of pantothenate, 0.0006-0.009 partof biotin, 7-11 parts of caffeine, 1-4 parts of apple polyphenols, 2-4 parts of grape seed extracts and a blending agent. Good-quality creatine monohydrate and 1,6-fructose diphosphate are selected torapidly synthetize ATP, so as to supply energy and assist in restoring strength; grape seed extracts and apple polyphenols have strong anti-oxidation effects and are capable of effectively eliminating free radicals, dilating blood vessels and conveying nutrients to muscles; beta-alanine is capable of improving the carnosine content of a human body, alleviating fatigue and promoting recovery; taurine is capable of improving the anti-anoxia capability of cardiac muscles and protecting the heart. The grape-flavor composite creatine integrates multiple useful ingredients and is convenient to eatfor people; compared with relevant foods directly eaten, the grape-flavor composite creatine can be better absorbed.

The present invention relates to a meat quality improving feed additive for fattening pigs and a preparation method and an application thereof, and belongs to the field of feed. The feed additive comprises 20-40 parts by weight of creatine monohydrate, 5-25 parts by weight of alpha-lipoic acid, 2-10 parts by weight of carnosine, 2-10 parts by weight of yucca extract and 15-71 parts by weight of carriers. The preparation method comprises the following steps: the carnosine, yuccan extract and carriers are mixed, then the creatine monohydrate and alpha-lipoic acid are added, and the materials are continuously mixed to obtain the finished products. The preparation method is simple and the preparation condition is good in controllability. The prepared feed additive by the method can slow down pH of muscles of the fattening pigs, increases water holding capacity of the muscles, improves meat color and tenderness, can be applied in the feed for the fattening pigs, can significantly improve the meat quality and flavor of the fattening pigs, at the same time improves antioxidant capacity of the fattening pig body and reduces ammonia nitrogen emission.