Synthesis process of creatine nitrate
Through the process flow of creatine reaction solution preparation, pretreatment of creatine preparation and nitrate preparation in the creatine nitrate synthesis process, the problems of low yield and high production cost of traditional processes are solved, and high yield and low cost creatine nitrate crystals are achieved.
Patent Information
- Application Number
- CN202510047923.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-01-13
- Publication Date
- 2025-03-25
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
The yield of traditional creatine nitrate synthesis process is low, and the mother liquor needs to be refined after crystallization, which increases production costs.
The process flow including preparation of nitric acid reaction solution, preparation of pretreatment creatine and preparation of nitrate is adopted. The pretreatment creatine is slowly added to the nitric acid reaction solution, and warm water is added to conduct a secondary reaction after cooling, and then color absorption is used with activated carbon, and finally freeze and crystallization is frozen.
It improves the crystallization yield of creatine nitrate, reduces side reactions, and reduces production costs.
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Figure SMS_1
Abstract
Description
Technical Field
[0001] The invention belongs to the technical field of wastewater treatment, in particular to a synthesis process of creatine nitrate. Background Art
[0002] Creatine nitrate can make creatine better utilized by the human body. Creatine is an amino acid produced naturally in the human body. It can quickly increase muscle strength and promote new muscle growth. It is also an important substance for the resynthesis of ATP (adenosine triphosphate). ATP is the direct energy source for muscle activity, but its storage capacity in the human body is very limited. During exercise, ATP will be consumed rapidly. At this time, creatine can quickly resynthesize ATP to provide continuous muscle movement energy. Therefore, creatine nitrate can help athletes maintain better performance in high-intensity exercise. As a sports nutrition product, creatine nitrate can provide multiple benefits to the human body under the premise of moderate use, diet, exercise and water supplementation.
[0003] The yield of traditional creatine nitrate synthesis process is generally low, and the mother liquor remaining after crystallization needs to be refined, which adds invisible costs to production. Summary of the invention
[0004] The purpose of the invention is to provide a synthesis process of creatine nitrate to solve the deficiencies in the prior art.
[0005] The technical solution adopted by the present invention is as follows: The synthesis process of creatine nitrate comprises the following steps: (1) Preparation of nitric acid reaction solution: adding nitric acid solution into water and stirring evenly to obtain nitric acid reaction solution; (2) Preparation of pretreated creatine: water, phosphatidylcholine and sepiolite are mixed, creatine monohydrate is added and stirred at room temperature to obtain pretreated creatine; (3) Preparation of nitrate: slowly add the pretreated creatine prepared in step (2) into the nitric acid reaction solution prepared in step (1), stirring while adding, and cooling after the addition is completed and the reaction is completed. After cooling, add warm water and stir to carry out a secondary reaction. After adding the warm water, let it stand, add activated carbon to absorb the color, and freeze it to crystallize.
[0006] Preferably, the concentration of the nitric acid solution in step (1) is 65-70% by mass.
[0007] Preferably, the weight ratio of the nitric acid solution to water in step (1) is 1:1 to 1.2.
[0008] Preferably, the sepiolite in step (2) is fibrous sepiolite.
[0009] Preferably, in the process of preparing the pretreated creatine in step (2), the weight ratio of the added creatine monohydrate to the mixed solution of water, phosphatidylcholine and sepiolite is 1.2-0.8-1.
[0010] Preferably, the temperature of the warm water added in step (2) is 45°C to 55°C.
[0011] Beneficial effects of the present invention: During the treatment process of the crystallization process of the present invention, by using fibrous sepiolite and then adding creatine monohydrate, a part of the creatine monohydrate can be adsorbed by the fibrous sepiolite, while the other part is dissolved in water, and by slowly adding nitric acid reaction solution, the creatine monohydrate adsorbed on the surface of the fibrous sepiolite can be slowly dissolved into the solution and continue to participate in the reaction, and warm water is added after cooling and stirred for secondary reaction, which provides reaction potential energy for the reaction of the remaining materials, can increase the product yield, and reduce side reactions. DETAILED DESCRIPTION Example 1
[0012] The synthesis process of creatine nitrate comprises the following steps: (1) Preparation of nitric acid reaction solution: adding nitric acid solution into water and stirring evenly to obtain nitric acid reaction solution; (2) Preparation of pretreated creatine: water, phosphatidylcholine and sepiolite are mixed, creatine monohydrate is added and stirred at room temperature to obtain pretreated creatine; (3) Preparation of nitrate: slowly add the pretreated creatine prepared in step (2) into the nitric acid reaction solution prepared in step (1), stirring while adding, and cooling after the addition is completed and the reaction is completed. After cooling, add warm water and stir to carry out a secondary reaction. After adding the warm water, let it stand, add activated carbon to absorb the color, and freeze it to crystallize.
[0013] The concentration of the nitric acid solution in step (1) is 65% by mass.
[0014] The weight ratio of the nitric acid solution to water in step (1) is 1:1.
[0015] The sepiolite described in step (2) is fibrous sepiolite.
[0016] In the process of preparing the pretreated creatine in step (2), the weight ratio of the added creatine monohydrate to the mixed solution of water, phosphatidylcholine and sepiolite is 1.2 to 0.8.
[0017] The temperature of the warm water added in step (2) is 45°C. Example 2
[0018] The synthesis process of creatine nitrate is characterized by comprising the following steps: (1) Preparation of nitric acid reaction solution: adding nitric acid solution into water and stirring evenly to obtain nitric acid reaction solution; (2) Preparation of pretreated creatine: water, phosphatidylcholine and sepiolite are mixed, creatine monohydrate is added and stirred at room temperature to obtain pretreated creatine; (3) Preparation of nitrate: slowly add the pretreated creatine prepared in step (2) into the nitric acid reaction solution prepared in step (1), stirring while adding, and cooling after the addition is completed and the reaction is completed. After cooling, add warm water and stir to carry out a secondary reaction. After adding the warm water, let it stand, add activated carbon to absorb the color, and freeze it to crystallize.
[0019] The concentration of the nitric acid solution in step (1) is 68% by mass.
[0020] The weight ratio of the nitric acid solution to water in step (1) is 1:1 to 1.1.
[0021] The sepiolite described in step (2) is fibrous sepiolite.
[0022] In the process of preparing the pretreated creatine in step (2), the weight ratio of the added creatine monohydrate to the mixed solution of water, phosphatidylcholine and sepiolite is 1.2 to 0.9.
[0023] The temperature of the warm water added in step (2) is 50°C. Example 3
[0024] The synthesis process of creatine nitrate is characterized by comprising the following steps: (1) Preparation of nitric acid reaction solution: adding nitric acid solution into water and stirring evenly to obtain nitric acid reaction solution; (2) Preparation of pretreated creatine: water, phosphatidylcholine and sepiolite are mixed, creatine monohydrate is added and stirred at room temperature to obtain pretreated creatine; (3) Preparation of nitrate: slowly add the pretreated creatine prepared in step (2) into the nitric acid reaction solution prepared in step (1), stirring while adding, and cooling after the addition is completed and the reaction is completed. After cooling, add warm water and stir to carry out a secondary reaction. After adding the warm water, let it stand, add activated carbon to absorb the color, and freeze it to crystallize.
[0025] The concentration of the nitric acid solution in step (1) is 68% by mass.
[0026] The weight ratio of the nitric acid solution to water in step (1) is 1:1.2.
[0027] The sepiolite described in step (2) is block-shaped sepiolite.
[0028] In the process of preparing the pretreated creatine in step (2), the weight ratio of the added creatine monohydrate to the mixed solution of water, phosphatidylcholine and sepiolite is 1.2 to 1.
[0029] The temperature of the warm water added in step (2) is 55°C.
[0030] Comparative Example 1 Creatine nitrate is synthesized using traditional technology.
[0031] The specific indicators for comparison are:
[0032] It can be seen from the above table that the crystallization of creatine nitrate prepared by the present invention not only has a greatly improved yield, but also can increase the product yield and reduce side reactions.
[0033] The above description is only a preferred embodiment of the present invention, but the present invention does not limit the scope of implementation. Any changes made in accordance with the concept of the present invention, or modifications to equivalent embodiments with equivalent changes, which still do not exceed the spirit covered by the description and embodiments, should be within the protection scope of the present invention.
Claims
1. The synthesis process of creatine nitrate is characterized by: The following steps are involved: (1) Preparation of nitric acid reaction solution: adding nitric acid solution into water and stirring evenly to obtain nitric acid reaction solution; (2) Preparation of pretreated creatine: water, phosphatidylcholine and sepiolite are mixed, creatine monohydrate is added and stirred at room temperature to obtain pretreated creatine; (3) Preparation of nitrate: slowly add the pretreated creatine prepared in step (2) into the nitric acid reaction solution prepared in step (1), stirring while adding, and cooling after the addition is completed and the reaction is completed. After cooling, add warm water and stir to carry out a secondary reaction. After adding the warm water, let it stand, add activated carbon to absorb the color, and freeze it to crystallize.
2. The synthesis process of creatine nitrate according to claim 1, characterized in that: The concentration of the nitric acid solution in step (1) is 65-70% by mass.
3. The synthesis process of creatine nitrate according to claim 1, characterized in that: The weight ratio of the nitric acid solution to water in step (1) is 1:1-1.
2.
4. The synthesis process of creatine nitrate according to claim 1, characterized in that: The sepiolite described in step (2) is fibrous sepiolite.
5. The synthesis process of creatine nitrate according to claim 1, characterized in that: In the process of preparing the pretreated creatine in step (2), the weight ratio of the added creatine monohydrate to the mixed solution of water, phosphatidylcholine and sepiolite is 1.2-0.8-1.
6. The synthesis process of creatine nitrate according to claim 1, characterized in that: The temperature of the warm water added in step (2) is 45°C to 55°C.