30 results about "Hepatoprotective Drugs" patented technology

The invention relates to a Chinese lizarbtail herb extract with the lignan content of higher than 50 percent, a preparation method thereof and applications in liver protection drugs and health care products, and the Chinese lizarbtail herb extract which is rich in lignan ingredient can be obtained by ethanol extraction, organic solvent extraction and a series of purification steps of Chinese lizarbtail herb medicinal material.

The invention discloses a ring-A polyoxidizing substituted glycyrrhetinic acid derivative and a preparation method and application thereof. The compound has the formula shown in the specification, wherein R1 is selected from carbonyl or hydroxyl; R2 and R3 are hydroxyl or an epoxy group exists between R2 and R3; R4 is selected from -COOH, -COOR1, -CONH2, -CONHR1 and -CONR1R2; R1 and R2 are selected from alkyl with 1-15 carbon atoms, substituted or unsubstituted phenyl, substituted or unsubstituted phenyl alkyl, and R1 and R2 can be same or different; Y is CH2 or C=O; hydrogen in the 18th site is alpha or beta-configuration; when R1, R2 and R3 are hydroxyl, the hydroxyl substituent configurations can be alpha or beta-configurations. The compound with a novel structure, which is provided by the invention, and the salt thereof have relatively strong hepatoprotective activity and can be used for preparing hepatoprotective medicines. The derivative has the application of resisting bacteria or tobacco mosaic virus, and has good application prospects in the fields of medicines and pesticides.

The present invention relates to a pharmaceutical composition useful as a hepatoprotective agent, said composition comprising of a mixture of coumarinolignoids of formula 1,2 and 3. The present invention also relates to a improved process for production of liver protective composition containing coumarinolignoids of formula 1, 2 and 3 from Cleome viscosa with optimized ratios of the same. More particularly, the present invention relates to a processing technology for the isolation of a combination of coumarinolignoids Cliv-92 comprising a mixture of coumarinolignoids of formula 1,2 and 3 from the seeds of Cleome viscosa.

The invention belongs to the technical field of biology, and specifically relates to preparation of Geranium wilfordii Maxim. polysaccharide and application of the Geranium wilfordii Maxim. polysaccharide in development of liver-protecting drugs. An immunological liver injury model induced by canavaline A is adopted, and the liver-protecting activity of the immunological liver injury model is investigated. An experiment result shows that the Geranium wilfordii Maxim. polysaccharide is capable of remarkably decreasing liver function indexes of a mouse with liver injury, can be used for researching and developing the liver-protecting drugs, particularly drugs for treating immunological liver injury. The application has an important significance to further development and utilization of Geranium wilfordii Maxim..

The invention relates to application of a steroid saponin compound in medicinal materials of trillium or paris polyphylla to preparation of a liver protection medicine. The prepared steroid saponin compound in the medicinal materials of trillium or paris polyphylla is one or more of pennogenin-3-0-alpha-L-rhamnopy ranosyl group(1 to 2)-beta-D-glucoside (namely polyphyllin VI), pennogenin-3-0-alpha-L-rhamnopy ranosyl group(1 to 4)-[alpha-L-rhamnopy ranosyl group(1 to 2)]-beta-D-glucoside and pennogenin-3-0-alpha-L-rhamnopy ranosyl group(1 to 4)-alpha-L-rhamnopy ranosyl group(1 to 4)-[alpha-L-rhamnopy ranosyl group(1 to 2)]-beta-D-glucoside (namely polyphyllin VII), and as the common structure units like the pennogenin-3-0-alpha-L-rhamnopy ranosyl group(1 to 2)-beta-D-glucoside (namely polyphyllin VI) are owned, the steroid saponin compound in the medicinal materials of trillium or paris polyphylla has remarkable effects of treating any hepatitis or liver injury in alcoholic hepatitis or liver injury, nonalcoholic hepatitis or liver injury, alcoholic fatty liver, non-alcoholic fatty liver, hepatic fibrosis or liver cirrhosis.

The invention discloses a tilapia mossambica precision-cut liver slice injury model and a construction method thereof. The method adopts cyclophosphamide to induce tilapia mossambica precision-cut liver slices, and the concentration of the cyclophosphamide is 25mM or below. Compared with the prior art, the method disclosed by the invention has the following advantages: (1) the cyclophosphamide-induced tilapia mossambica precision-cut liver slices are adopted for the first time to construct an injury model, and a basis is provided for researching a fish liver injury mechanism and screening and developing liver protection drugs; and (2) a tilapia mossambica precision-cut liver slice is adopted as an induction object of the method, the in-vivo state is simulated to the maximum extent, and the method is a more reliable model system for researching liver metabolism and in-vitro induction toxicity.

The invention provides novel medical application of a manganese superoxide dismutase stimulant MnSODm in preparing a liver-protecting drug. By investigating the protective effect of a manganese superoxide dismutase stimulant compound to mice acute liver injury induced by carbon tetrachloride, the MnSODm has an obvious protective effect to the mice acute liver injury induced by CCI4, and therefore, the manganese superoxide dismutase stimulant can be used for preparing the liver-protecting drug, i.e., pharmaceutically acceptable preparation can be prepared by using the manganese superoxide dismutase stimulant as an active ingredient according to a conventional process and auxiliary materials.

The invention discloses a Phlomis maximowiczii extract, as well as an extraction method and application thereof in preparation of antioxidant drugs and hepatoprotective drugs, and belongs to the technical field of medicines. The Phlomis maximowiczii extract contains a petroleum ether extract, an ethyl acetate extract and an n-butanol extract. The extraction method comprises the following steps: (1) collecting whole plants of Phlomis maximowiczii, washing, drying in a dark place, grinding and then extracting by soaking in methanol, recovering methanol to obtain a total extract; (2) dispersing the total extract in an ethanol aqueous solution, adding petroleum ether for extraction, and recovering petroleum ether to obtain the petroleum ether extract; (3) adding ethyl acetate into the solution for extraction after petroleum ether extraction, and recovering ethyl acetate to obtain the ethyl acetate extract; and (4) adding n-butanol into the solution after ethyl acetate extraction and recovering n-butanol to obtain the n-butanol extract. The Phlomis maximowiczii extract has antioxidant and hepatoprotective effects and can be used for preparing antioxidant and hepatoprotective health foods or drugs.

The invention relates to the field of biological medicines, and concretely relates to application of demethylenetetrahydroberberine hydrochloride in the preparation of a medicine for preventing and / ortreating liver injury induced by thioacetamide. The demethylenetetrahydroberberine hydrochloride medicine has the advantages of good solubility, good medicine absorptivity and good anti-inflammatoryand antioxidant activity, and has a remarkable treatment effect on thioacetamide-induced acute mild and chronic liver injury; and compared with the traditional liver protection medicine, the demethylenetetrahydroberberine hydrochloride can achieve the treatment purpose under a low oral administration dosage, can improve the patient compliance, and achieves the treatment effect on diseases.

The invention discloses application of melanin extracted from auricularia auricula in a liver-protection product, and belongs to the technical field of medicines and food. According to the applicationdisclosed by the invention, protein in an auricularia auricula fruiting body is destroyed through strong acid, and the melanin is precipitated out through an alkali solution to obtain precipitants, and the precipitants are collected so as to obtain a melanin crude extract; purifying the melanin crude extract by sequentially using ethanol, ethyl acetate and acetone to obtain the purified melanin;using the melanin in a liver-protection product (including a liver-protection medicine or liver-protection food), wherein the melanin component accounts for 0.1 to 100 percent by weight of the liver-protection product. According to the application of the melanin extracted from the auricularia auricula in the liver-protection product disclosed by the invention, the melanin extracted from the auricularia auricula is used in the liver-protection product, so that the effective liver-protection component, namely the melanin, has obvious effects on prevention or treatment of virus hepatitis, drug-induced liver injury, alcohol liver and fatty liver. In addition, the application of the melanin extracted from the auricularia auricula in the liver-protection product disclosed by the invention has the advantages of simple and feasible process and low cost, and is suitable for industrially mass production.

The invention relates to a method for preparing dehydrodiconify alcohol or an ethyl acetate extract of semen hertospermi with dehydrodiconify alcohol as the main active ingredient and application thereof in hepatoprotective drugs for preventing or treating liver damage. The extraction method includes the following steps that pulverized semen hertospermi is pulverized and extracted with ethanol, the extract is extracted with ethyl acetate, and concentration under reduced pressure is conducted to form the extract. It is found through experiments that dehydrodiconify alcohol can significantly reverse the increase of liver function levels such as ALT and AST in the serum of ANIT-induced cholestasis SD rats, the decrease of bile flow and liver lesions, and has a significant anti-liver damage protective effect; dehydrodiconify alcohol acts mainly by modulating downstream gene expression based on activation of an FXR target. The application range of dehydrodiconify alcohol and the ethyl acetate extract of semen hertospermi is broadened, and the method for preparing dehydrodiconify alcohol or the ethyl acetate extract of semen hertospermi with dehydrodiconify alcohol as the main active ingredient and the application thereof in the hepatoprotective drugs for preventing or treating liver damage have important application value and economic benefit for the development of FXR agonistic drugs and anti-liver damage protective drugs.

The invention relates to a new rotenone-type flavonoid compound and a preparation method and application thereof. The structural formula of the new rotenone-type flavonoid compound is shown in the description. The new rotenone-type flavonoid compound is novel in structure and has significant hepatoprotective activity, the extraction and separation method is simple, and an important experimental foundation and theoretical basis are provided for discovering novel hepatoprotective drugs from flos pyrethri tatsienensis.

The invention discloses a compound traditional Chinese medicine preparation used for treating liver function damage. The compound traditional Chinese medicine preparation used for treating liver function damage is composed of, by weight, 6 to 10 parts of radix pseudostellariae, 8 to 10 parts of Radix Astragali, 1 to 4 parts of Herba Artemisiae Capillariae, 6 to 8 parts of Artemisia carvifolia, 5 to 10 parts of Radix Codonopsis, 2 to 4 parts of bighead atractylodes rhizome, 4 to 6 parts of white peony root, 3 to 5 parts of coix seed, 5 to 8 parts of radix bupleuri, 4 to 8 parts of Semen Hoveniae, 8 to 10 parts of Chinese Magnoliavine Fruit, 2 to 4 parts of Sedum sarmentosum, 3 to 5 parts of hyacinth bean, 4 to 6 parts of dried orange peel, 8 to 10 parts of fingered citron, 4 to 7 parts of Radix Scutellariae, and 3 to 5 parts of licorice. The compound traditional Chinese medicine preparation is prepared via decoction, is capable of regulating body internal organs and restoring liver, reducing transaminase and total bilirubin to normal values, and realizing recovery of liver functions more quickly than liver protection drugs used in the prior art; and no relapse is caused.

The invention discloses a Tilapia mossambica fatty liver damage model and a building method and application thereof. The building method includes: domesticating, preparing high-fat feed, inducing andperforming detection and analysis. Compared with the prior art, the method has the advantages that the high-fat feed used by the method is simple in formula, easy to operate, easy in component control, high in modeling success rate, stable, short in modeling time and promising in application prospect; the animal model built by the method can be used for researching the pathogenesis of fish fatty liver damage caused by various factors and the mutual relation between fat metabolic disorder and liver damage, screening drugs for preventing and treating fish fatty liver and evaluating the pharmacological mechanism of fish liver-protecting drugs.

The invention discloses an application of tannic acid in preparation of hepatoprotective drugs, and relates to the technical field of new application of tannic acid. The application in preparation of the hepatoprotective drugs is provided. The invention relates to the application in preparation of drugs for achieving multi-target treatment of hepatotoxicity through anti-oxidative stress, anti-inflammation and anti-apoptosis functions, especially in preparation of acetaminophen induced hepatotoxicity drugs. The invention discloses the new drug application of the polyphenol compound tannic acid.

The invention discloses an application of an aqueous extract extracted from cordyceps militaris sporophore in liver protection products, and belongs to the technical field of medicines and foods. Highantioxidant active sites of cordyceps militaris MF27 are screened, the aqueous extract extracted from sporophore of the cordyceps militaris MF27 is found to have the best scavenging effect on DPPH free radicals and hydroxyl free radicals with EC50 values of 0.167 mg / mL and 0.245 mg / mL, respectively. The aqueous extract with high antioxidant activity is applied to liver protection products (such as liver protection medicines and liver protection health care products) with a percentage accounting for 0.5-100% of the liver protection products, and the liver protection products are found to playa good role in preventing and relieving liver diseases such as fatty liver, alcoholic liver, viral hepatitis and drug-induced hepatitis. The application provides a theoretical basis for development and application of liver protection products related to cordyceps militaris.

The invention belongs to the technical field of medicines, and particularly relates to novel application of cajanin in prevention and treatment of drug-induced liver injury. Animal experiments firstly prove and disclose that cajanin can effectively treat drug-induced liver injury caused by acetaminophen. The invention further discloses application of the cajanin to preparation of the medicine for preventing and / or treating the medicine-induced liver injury. The invention provides a scientific basis for developing the liver-protecting medicine taking the cajanin as the active ingredient, and has important application value.

The invention discloses a standardized extract of red jujube leaves and its preparation method and application. The extract contains the following components: oleic acid-3-O-trans-p-coumaroyl ester 134.96 μg / g; Acid-3-O-cis-p-coumaroyl ester 5.27μg / g; benzoic acid 6.75μg / g; 2,4-dihydroxyphenol 6.47μg / g; p-hydroxybenzoic acid 77.14μg / g; o-hydroxybenzoic acid Benzoic acid 2.24μg / g; rutin 25.13μg / g; p-hydroxybenzaldehyde 10.25μg / g; maslinic acid-3-O-trans-p-coumaroyl ester 3.84μg / g; p-hydroxycis-cinnamic acid 1.71μg / g; p-hydroxy trans-cinnamic acid 9.38μg / g; 3,4-dihydroxybenzoic acid: 1.85μg / g. Activity test results show that the red date leaf extract has hepatoprotective activity and can be used to make hepatoprotective drugs.

The invention relates to a new rotenone-type flavonoid compound and its preparation method and application. The structural formula of the new rotenone-type flavonoid compound is as follows:. The new rotenone-type flavonoids have a novel structure, simple extraction and separation methods, and significant hepatoprotective activity, providing an important experimental basis and theoretical basis for the discovery of new hepatoprotective drugs from Arrowflower.

The present invention discloses an application of cordycepin in preparing hepatoprotective products and belongs to the technical field of medicine and food. A cordycepin pure product is applied to thehepatoprotective products (hepatoprotective drugs and hepatoprotective food). The mass percentage of the cordycepin component in the hepatoprotective products is 0.01-100%. The cordycepin can effectively prevent and treat fatty liver, alcoholic liver, viral hepatitis, drug-induced hepatitis and other liver diseases, and provides new ideas for development and application of the cordycepin-relatedhepatoprotective products.

The present invention relates to the technical field of drug development and production, in particular to an anti-inflammatory and liver-protecting drug. The drug is composed of the following components in weight ratio: 30-35 parts of Desmodium, 10-15 parts of green bark, and 10-15 parts of tiger 12 to 18 parts of palm grass, 15 to 20 parts of soft liver grass, 10 to 20 parts of chicken bone grass, 15 to 25 parts of Tangut green orchid, 10 to 30 parts of Huangsuo Meigen, 20 to 30 parts of capillary root, 3 to 30 parts of mulberry root 8 parts, 5 to 10 parts of licorice, 10 to 15 parts of Pteris. Compared with the prior art, the present invention has the beneficial effects that: the present invention can reduce inflammation, clear away heat and protect the liver.

The present invention provides a sodium valproate compound preparation and a use thereof. Aiming at adverse reactions of liver function damages or memory impairment, etc. caused by sodium valproate, the adverse reactions are prevented and treated by adding a common hepatoprotective drug of polyene phosphatidylcholine, toxic and side effects are reduced, and problems of patient administration convenience and compliance are solved. Besides, the sodium valproate compound preparation is simple in technology, convenient for mass production, and safe and reliable in product quality.

Particularly relates to application of dianthrone compounds in preparation of anti-inflammatory and liver-protecting medicines, and belongs to the technical field of biological medicines. The invention provides an application of a dianthrone compound in preparation of an anti-inflammatory and liver-protecting medicines. The dianthrone compound comprises Trans-emodin dianthrone and / or Cis-emodin dianthrone. The invention provides application of the dianthrone compound in preparation of anti-inflammatory and liver-protecting medicines, and results of the embodiment show that the dianthrone compound has the following significant pharmacological activities: significantly improving immune liver injury of mice, improving pathological injury of liver tissues, and reducing serum liver injury biomarkers.

The invention relates to a preparation method and an application of coumarin glycoside compounds and can effectively solve the problems about preparation of novel coumarin glycoside compounds with liver protection activity and the application of the coumarin glycoside compounds in preparation of liver protection drugs. The novel coumarin glycoside compounds with the liver protection activity are genglycoside A I, genglycoside B II and genglycoside D III which are separated from the medicinal material of common gendarussa herb. The preparation method is simple, the reproducibility is good, theobtained compounds have high purity and are favorable for further pharmacological and clinical research, the prepared novel coumarin glycoside compounds with the liver protection activity, namely, genglycoside A I, genglycoside B II and genglycoside D III, are effectively used for preparing the liver protection drugs, a new way of the liver protection drugs and medicinal value and commercial valueof the common gendarussa herb are opened up, and the economic and social benefits are remarkable.

The invention discloses application of gymnadenia conopsea to preparing a lipid lowering and liver protecting medicament. Dried gymnadenia conopsea, serving as a raw material, is prepared into a medicament comprising gymnadenia conopsea alcohol extraction extract as an active ingredient through alcohol extraction, and is applied to lowering lipid and protecting liver at the daily intake of 5-30g / day. The invention shows that the gymnadenia conopsea has the effect of improving abnormal lipid metabolism by reducing blood serum and triglyceride of the liver. Meanwhile, the blood serum ALT (alanine aminotransferase) content (p is less than 0.05) can be obviously reduced through low dosage of the gymnadenia conopsea, and high dosage and medium dosage have extremely obvious difference (p is less than 0.01, p is less than 0.05) in reducing blood serum AST (Aspartate Transaminase) content, so that liver damage caused by lipid metabolic disturbance can be reduced.