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Application of manganese superoxide dismutase stimulant in preparing liver-protecting drug

A technology of superoxide and dismutase, applied in the field of medicine, can solve problems that have not been reported yet

Inactive Publication Date: 2013-07-31
甘肃省人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Free radicals play an important role in the process of liver injury, but the study of MnSODm on liver injury has not been reported yet

Method used

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  • Application of manganese superoxide dismutase stimulant in preparing liver-protecting drug
  • Application of manganese superoxide dismutase stimulant in preparing liver-protecting drug
  • Application of manganese superoxide dismutase stimulant in preparing liver-protecting drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Embodiment 1, preparation of liver-protecting granule

[0063] Raw material ratio: MnSODm 200 mg, starch 500 g, sugar powder 500 g;

[0064] Preparation process: After sieving MnSODm, add starch, sugar powder and appropriate amount of water to MnSODm, mix evenly, make soft material, pass through a 14-mesh nylon sieve to granulate, dry the wet granules at 60°C, and pass the dry granules through a 14-mesh sieve for granulation , and then pass through a No. 4 sieve (65 mesh) to remove fine powder, then pack, seal, and pack. Specification: 2mg: 10g

[0065] Dosage: 2 times a day, 1 bag each time.

Embodiment 2

[0066] Embodiment 2, the preparation of liver-protecting capsule

[0067] Raw material ratio: MnSODm 200 mg, appropriate amount of 10% starch slurry, appropriate amount of food coloring, made into 100 hard capsules in total.

[0068] Preparation process: After MnSODm passes through a 80-mesh sieve, add 10% starch, food coloring and appropriate amount of water, mix evenly, make a soft material, pass through a 14-mesh nylon sieve to granulate, dry at 70°C until the water content is below 3%, and fill into empty capsules In, that is.

[0069] Dosage: 2 times a day, 1 capsule each time.

Embodiment 3

[0070] Embodiment 3, the preparation of hepatoprotective injection preparation

[0071] Raw material ratio: MnSODm 200 mg, sodium chloride 850 mg, Tween 1 mL, water for injection to 100 mL.

[0072] Preparation process: In a preparation container, add 80% of the prescription amount of water for injection, add 200 mg of MnSODm, sodium chloride and Tween, stir to dissolve completely, filter, pot, and sterilize at 100°C for 30 minutes. Specification 2mg: 1mL

[0073] Dosage: 2 times a day, 1 bottle at a time.

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PUM

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Abstract

The invention provides novel medical application of a manganese superoxide dismutase stimulant MnSODm in preparing a liver-protecting drug. By investigating the protective effect of a manganese superoxide dismutase stimulant compound to mice acute liver injury induced by carbon tetrachloride, the MnSODm has an obvious protective effect to the mice acute liver injury induced by CCI4, and therefore, the manganese superoxide dismutase stimulant can be used for preparing the liver-protecting drug, i.e., pharmaceutically acceptable preparation can be prepared by using the manganese superoxide dismutase stimulant as an active ingredient according to a conventional process and auxiliary materials.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a new medicine application of a manganese superoxide dismutase simulant MnSODm—the application in the preparation of liver-protecting medicine. Background technique [0002] The liver is an extremely important organ in animals, involved in various functions such as digestion, metabolism, excretion, detoxification and immunity. The liver is an important target for attack by various substances. Liver dysfunction caused by liver injury is a common pathological manifestation of various liver diseases. Harmful factors attack target cells, causing cell damage, producing and releasing a series of inflammatory mediators, causing cell apoptosis or necrosis, and ultimately leading to the occurrence of various liver diseases . The mechanism of liver injury is very complex, which is the result of the combined effects of multiple factors at multiple levels, multiple targets, and multiple pat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/44A61P1/16
Inventor 李红玲王艳红
Owner 甘肃省人民医院
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