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Sodium valproate compound preparation and use thereof

A technology of sodium valproate and compound preparations, which is applied in the direction of pharmaceutical formulas, medical preparations of non-active ingredients, active ingredients of anhydride/acid/halide, etc., to achieve enhanced therapeutic effect, fast absorption, and prevention of liver function damage

Inactive Publication Date: 2019-12-31
四川健能制药有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Sodium valproate and polyene phosphatidylcholine have been clinically used for many years and have very definite clinical therapeutic effects, but the two drugs are made into a compound preparation so that they can treat localized, generalized or other types of epilepsy attack, and can prevent possible liver damage or memory impairment, which has not been reported at home and abroad

Method used

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  • Sodium valproate compound preparation and use thereof
  • Sodium valproate compound preparation and use thereof
  • Sodium valproate compound preparation and use thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0029] The preparation of embodiment 1 test medicine

[0030] The present invention will be further described below in conjunction with specific experimental groups, but it should not be understood that the scope of the above subject of the present invention is limited to the following experimental groups. All technologies realized based on the above contents of the present invention belong to the scope of the present invention. The excipients in the following experimental groups can be replaced, reduced or increased with pharmaceutically acceptable similar excipients.

[0031] Experimental group 1

[0032]

[0033] Preparation Process:

[0034] (1) Take purified water accounting for 40% of the total amount, slowly add hydroxyethyl cellulose, stir until it swells completely, and obtain solution A.

[0035] (2) Take 20% of the total amount of purified water to dissolve sodium valproate, preservatives, correctives, fragrances and coloring agents to obtain solution B.

[0...

Embodiment 2

[0053] Embodiment 2 active investigation

[0054] 1. Purpose of the test

[0055] Through the test, the degree of control of epileptic seizures, learning and memory functions and changes in liver tissue cells were observed in rats after using the medicine of the present invention and the medicine of the control group respectively.

[0056] 2. Test materials

[0057] 1. Test drug: the drug of the present invention, sodium valproate oral solution (registration number H20041435), polyene phosphatidylcholine capsules (registration number H20059010).

[0058] 2. Animals: healthy male SD rats with a body weight of 235-268 g.

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Abstract

The present invention provides a sodium valproate compound preparation and a use thereof. Aiming at adverse reactions of liver function damages or memory impairment, etc. caused by sodium valproate, the adverse reactions are prevented and treated by adding a common hepatoprotective drug of polyene phosphatidylcholine, toxic and side effects are reduced, and problems of patient administration convenience and compliance are solved. Besides, the sodium valproate compound preparation is simple in technology, convenient for mass production, and safe and reliable in product quality.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a compound preparation containing sodium valproate and polyene phosphatidylcholine and its application. Background technique [0002] Epilepsy is a brain dysfunction syndrome characterized by recurrent epileptic seizures caused by abnormal discharge of brain neurons. The main symptoms include: sudden general rigidity, clonus, convulsions and so on. Epilepsy is a chronic disease that can persist for several years and has serious adverse effects on the patient's body, spirit, marriage, and socioeconomic status. In severe cases, it can be life-threatening. [0003] The current drugs for the treatment of epilepsy mainly include carbamazepine, sodium valproate, phenytoin, oxcarbazepine, topiramate, lamotrigine, and levetiracetam. Among them, sodium valproate has a good curative effect on localized, generalized or other types of epileptic seizures, and is a universal antiepil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/19A61K31/685A61K47/38A61P1/16A61P25/08A61P25/20
CPCA61K9/0095A61K31/19A61K31/685A61K47/38A61P1/16A61P25/08A61P25/20A61K2300/00
Inventor 叶世春倪菁唐检珍
Owner 四川健能制药有限公司
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