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Application of tannic acid in preparation of hepatoprotective drugs

A technology of tannic acid and medicine, which is applied in the field of tannic acid, can solve the problem that tannic acid has no protective effect on liver acute injury, and achieve the effect of protecting liver cells

Inactive Publication Date: 2017-02-22
HEBEI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there has been no report on the protective effect of tannic acid on acute liver injury

Method used

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  • Application of tannic acid in preparation of hepatoprotective drugs
  • Application of tannic acid in preparation of hepatoprotective drugs
  • Application of tannic acid in preparation of hepatoprotective drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1 Protective effect of tannic acid on liver injury caused by acetaminophen.

[0043] 1 Materials and methods:

[0044] 1.1 Experimental animals

[0045] Fifty purebred male Kunming mice weighing 18-22 g were purchased from the Experimental Animal Center of Hebei Medical University.

[0046] 1.2 Experimental Drugs

[0047] Tannic acid (TA) was purchased from Sigma Chemicals (St. Louis, MO, USA).

[0048] Acetaminophen (Acetaminophen, APAP) was purchased from Sigma Chemicals (St. Louis, MO, USA).

[0049] Silymarin (Silymarin, Sily) was purchased from Xi'an Yihe Bioengineering Co., Ltd. (Xi'an, China).

[0050] 1.3 Model preparation

[0051]After one week of routine observation, the experimental animals were randomly divided into 5 groups, with 10 animals in each group. They were blank control group (Con), APAP-induced liver injury model control group (400mg / kg, APAP), TA low-dose group (25mg / kg, L-TA), TA high-dose group (50mg / kg, H-TA ) and Sily positive ...

Embodiment 2

[0072] Embodiment 2 prepares oral tablet

[0073] Tablets are prepared according to methods known in the art, each containing the following ingredients:

[0074]

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Abstract

The invention discloses an application of tannic acid in preparation of hepatoprotective drugs, and relates to the technical field of new application of tannic acid. The application in preparation of the hepatoprotective drugs is provided. The invention relates to the application in preparation of drugs for achieving multi-target treatment of hepatotoxicity through anti-oxidative stress, anti-inflammation and anti-apoptosis functions, especially in preparation of acetaminophen induced hepatotoxicity drugs. The invention discloses the new drug application of the polyphenol compound tannic acid.

Description

technical field [0001] The present invention relates to a new application of tannic acid, in particular to the application of tannic acid in the preparation of drugs with the effect of protecting the liver. Background technique [0002] Tannic acid (tannic acid), also known as tannic acid and tannin, is a kind of tannin obtained from gallnut. Molecular formula is C 76 h 52 o 46 , with a relative molecular mass of 1701.20, light yellow to light brown amorphous powder or loose shiny scaly or spongy solid, which can turn black when exposed to air. Odorless, slightly special smell, with a strong astringent taste, exposure to light and air darken the color. Soluble in water, easily soluble in ethanol, acetone and glycerin, almost insoluble in ether, benzene, chloroform and petroleum ether, CAS number: 1401-55-4. [0003] Acetaminophen is a typical dose-dependent hepatotoxic drug, which forms a highly active intermediate metabolite N-acetyl-p-benzoquinone imine (NAPQI) throug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7024A61P1/16
CPCA61K31/7024
Inventor 张建平宋琼涛楚立张园园
Owner HEBEI UNIV OF CHINESE MEDICINE
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