Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of gymnadenia conopsea to preparing lipid lowering and liver protecting medicament

A lipid-lowering, liver-protecting and drug-based technology, applied in drug combinations, pharmaceutical formulas, plant raw materials, etc., can solve the problems of undiscovered blood lipid-lowering and liver-protecting effects of hand ginseng

Inactive Publication Date: 2011-11-23
SOUTHWEST JIAOTONG UNIV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0025] There is no research on hypolipidemic and hepatoprotective effects of hand ginseng at home and abroad

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of gymnadenia conopsea to preparing lipid lowering and liver protecting medicament
  • Application of gymnadenia conopsea to preparing lipid lowering and liver protecting medicament
  • Application of gymnadenia conopsea to preparing lipid lowering and liver protecting medicament

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0043] 2.2 Preparation of drugs

[0044] 2.2.1 Preparation of high, medium and low doses of ginseng

[0045] Hand ginseng extraction: 70% ethanol, 10 times the amount, 40KHz ultrasonic extraction for 1 hour, extracted twice, combined.

[0046] Dispensing:

[0047] High dose of hand ginseng (5g / kg / d): Weigh 200g of hand ginseng raw medicinal material fine powder, ultrasonically extract twice according to the optimal process of orthogonal investigation (70% ethanol, 10 times the amount of ethanol, 40KHz, extraction for 90min), filter, The two filtrates were combined, concentrated by rotary evaporation at 50°C to a liquid extract, and the volume was adjusted to 660mL with 0.5% CMC-Na (sodium carboxymethylcellulose) solution, which is equivalent to 0.3g of crude drug per milliliter. Take 360mL for the high dose and seal it.

[0048] Medium dose of hand ginseng (2.5g / kg / d): Dilute the remaining medicinal solution after pipetting the high dose above to 600mL with 0.5% CMC-Na solu...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses application of gymnadenia conopsea to preparing a lipid lowering and liver protecting medicament. Dried gymnadenia conopsea, serving as a raw material, is prepared into a medicament comprising gymnadenia conopsea alcohol extraction extract as an active ingredient through alcohol extraction, and is applied to lowering lipid and protecting liver at the daily intake of 5-30g / day. The invention shows that the gymnadenia conopsea has the effect of improving abnormal lipid metabolism by reducing blood serum and triglyceride of the liver. Meanwhile, the blood serum ALT (alanine aminotransferase) content (p is less than 0.05) can be obviously reduced through low dosage of the gymnadenia conopsea, and high dosage and medium dosage have extremely obvious difference (p is less than 0.01, p is less than 0.05) in reducing blood serum AST (Aspartate Transaminase) content, so that liver damage caused by lipid metabolic disturbance can be reduced.

Description

technical field [0001] The invention relates to the efficacy of plant medicines, especially the technical field of application in hand ginseng medicines. Background technique [0002] Traditional Chinese medicine does not have a disease name for hyperlipidemia. According to its common clinical syndromes such as dizziness, chest tightness, palpitations, limb numbness, and fatigue, it can be classified into the categories of dizziness, chest obstruction, stroke, blood fatigue, and phlegm dampness. However, the understanding of lipids in Chinese medicine has a long history. For example, it is said in "Lingshu·Weiqi Disorder Fifty-ninth": "People have fat, cream and flesh...." Those whose meat is firm...the ointment has more qi, the more qi is hot, and the hot is cold-resistant.”, vividly describing some functions of lipids in the human body. If there is too much grease, there will be physical changes, which are called "grease people" and "fat people", and if there is less, "th...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/898A61P3/06A61P1/16
Inventor 闫智勇张天娥
Owner SOUTHWEST JIAOTONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com