Drug for preventing and controlling fulminant hepatitis

A technology for fulminant and hepatitis, applied in the field of medicine, can solve problems such as poor clinical prognosis, limited conservative treatment methods, and difficult implementation

Active Publication Date: 2020-01-17
THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Once fulminant hepatitis develops, the condition will deteriorate rapidly. At present, supportive treatment is mainly aimed at various complications (hepatic encephalopathy, respiratory and circulatory failure, renal failure, coagulation disorders, infection, gastrointestinal bleeding). The disease progresses rapidly, conservative treatment options are limited, and the clinical prognosis is extremely poor
Liver transplantation is still the ultimate treatment for severe fulminant hepatitis, but it is very difficult to implement due to the limitation of transplantation conditions

Method used

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  • Drug for preventing and controlling fulminant hepatitis
  • Drug for preventing and controlling fulminant hepatitis
  • Drug for preventing and controlling fulminant hepatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0031] Male C57BL / 6 mice were purchased from the Animal Experiment Center of Chongqing Medical University, and raised in the SPF level breeding room of the Animal Experiment Center of Chongqing Medical University. Male C57BL / 6, age 6-8 weeks, body weight 18-21g, were divided into 4 groups, including normal control group, model group, normal administration group and treatment group.

[0032] The normal control group was given the same amount of PBS by the same injection method;

[0033] The model group was given intraperitoneal injection of LPS7.5μg / kg, D-GalN 500mg / kg;

[0034] The normal drug group was given intraperitoneal injection of 5 μg of C14-Tri-LAN-Gly per mouse;

[0035] The treatment group was given intraperitoneal injection of C14-Tri-LAN-Gly 5 μg / rat 6 hours before the administration of the model group (LPS / D-GalN).

[0036] Blood and liver tissue were collected 6 hours after LPS / D-GalN injection for subsequent analysis. Another two groups of mice were selected...

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Abstract

The invention relates to the technical field of medicines, in particular to a drug for preventing and controlling fulminant hepatitis. Research shows the expression of the liver tissue A20 can be regulated up greatly by the NOD1 receptor agonist; the A20 (also called TNFAIP3) refers to anti-inflammatory signaling molecule, and can achieve anti-apoptosis action by lowering NF-kB signal channel, soas to protect the liver cells. Besides, the NOD1 receptor agonist can decrease the serum ALT level and the liver tissue cl-caspase3 level of mice with fulminant hepatitis greatly, thereby reducing liver injury of the mice with fulminant hepatitis and decreasing apoptosis of the liver cells. The conclusion is the NOD1 receptor agonist can be applied to treating fulminant hepatitis.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a medicine for preventing and treating fulminant hepatitis. Background technique [0002] Fulminant hepatitis is currently considered to be the initiating link and common path of various serious liver diseases. Its onset is sudden and its prognosis is very poor. If it is not treated correctly, it can further lead to severe liver failure and multiple organ dysfunction, and it is very difficult to treat. Clinical mortality is high. Sepsis induced by LPS, a cell wall component of Gram-negative bacteria, plays a key role in fulminant hepatitis and is one of the common critical illnesses in ICU. When the intestinal permeability is increased due to various reasons, bacteria in the intestinal tract can enter the blood vessels of the intestinal wall and further reach the liver to cause an inflammatory response. [0003] LPS is a component of the outer wall of bacterial cells, and it i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61P1/16
CPCA61K45/00A61P1/16
Inventor 殷文伟贾方任红
Owner THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIV
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