Application of glycerol fructose in non-surgical indication cancerous intestinal obstruction

A technology for indications and intestinal obstruction, applied in the field of chemical medicine, can solve the problem of less drugs for cancerous intestinal obstruction, and achieve the effects of improving abnormal metabolism, significant curative effect, and reducing treatment costs.

Inactive Publication Date: 2021-02-19
ANHUI PROVINCIAL CANCER HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Very few drugs currently available for nonsurgical indications for cancerous ileus

Method used

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Embodiment Construction

[0019] The technical solutions in the embodiments of the present invention will be clearly and completely described below, obviously, the described embodiments are only some of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0020] The scheme of the present invention is included in the standard:

[0021] (1) Age ≥ 18 years old, histopathologically confirmed malignant tumors, regardless of gender;

[0022] (2) Intestinal obstruction caused by primary or metastatic malignant tumors in the abdominal cavity / peritoneum confirmed by CT or MRI one month before enrollment;

[0023] (3) At least two of the following four symptoms: (a) vomiting (occurs >2 times in 24 hours or requires gastrointestinal decompression), (b) abdominal pain, (c) anal non-gassi...

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Abstract

The invention discloses application of glycerin fructose in non-surgical indication cancerous intestinal obstruction, and belongs to the field of chemical medicine. The non-surgical indication cancerous intestinal obstruction is intestinal obstruction caused by primary or metastatic malignant tumors, and is a common complication of end-stage abdominal and pelvic cavity malignant tumors. The application method is characterized in that intravenous infusion of 250-500 ml of glycerin fructose injection is conducted each time, and intravenous infusion is conducted for 1-2 times each day. Glycerol fructose can achieve the effects of relieving intestinal wall edema, improving obstruction-section intestinal canal microcirculation, correcting electrolyte disorder, supplying energy, saving liquid space and the like, and the supplied energy is glycerol and fructose instead of glucose, so that tumor cell energy uptake is not facilitated.

Description

technical field [0001] The invention relates to the field of chemical medicine, in particular to the application of glycerol fructose in non-operative indication cancer intestinal obstruction. Background technique [0002] Cancerous intestinal obstruction, also known as malignant intestinal obstruction, is intestinal obstruction caused by primary or metastatic malignant tumors, and is a common complication of advanced abdominal and pelvic malignant tumors. Research data show that the incidence of ovarian cancer cancerous intestinal obstruction is as high as 5.5% to 42%, colorectal cancer is 10% to 28%, and gastric cancer is 30% to 40%. Intestinal obstruction is more common. Small bowel obstruction (50% to 61%) and large bowel obstruction (3% to 37%) are the most common sites of obstruction. More than 20% of MBOs have both large and small bowel obstructions. The prognosis of MBO is extremely poor, and the median survival time is only 90 days. MBO leads to blockage of intes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7004A61K31/047A61P1/00A61P35/00
CPCA61K31/047A61K31/7004A61P1/00A61P35/00A61K2300/00
Inventor 杨守梅李苏宜尉浩斌李世伟刘伟巍
Owner ANHUI PROVINCIAL CANCER HOSPITAL
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