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Compound Dai medicine extract with liver-protecting effect and preparation method thereof

A technology of composite extracts and Dai medicines, which is applied in fields with significant

Inactive Publication Date: 2014-11-12
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, neither traditional Chinese medicine nor modern medicine has a good way to directly kill the hepatitis virus in the patient's body. Therefore, preventing liver damage and blocking the development of hepatitis-hepatic fibrosis-cirrhosis-liver cancer are effective methods for the treatment of viral hepatitis. So that the patient is in the state of lifelong asymptomatic virus carrier, which will greatly prolong life and improve the quality of life

Method used

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  • Compound Dai medicine extract with liver-protecting effect and preparation method thereof
  • Compound Dai medicine extract with liver-protecting effect and preparation method thereof
  • Compound Dai medicine extract with liver-protecting effect and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation of embodiment 1 extract (TQW)

[0023] The present invention prepares extract by following method:

[0024] (1) In terms of parts by weight, according to 1 part of the dried medicinal material of cat's whiskers, 1 part of dried medicinal materials of vine rootless and 1 part of dried medicinal materials of Gushanlong, an appropriate amount of each medicinal material was weighed, mixed and pulverized, and passed through a No. 2 sieve in the Pharmacopoeia.

[0025] (2) Take the medicinal material powder obtained in (1), add 70% ethanol with 10-30 times the weight of the medicinal material, heat and reflux extraction, and the number of extractions is 1-3 times.

[0026] (3) Take the liquid medicine extracted in (2), and concentrate it in a rotary evaporator, the temperature of the concentrated water bath does not exceed 60°C, and finally obtain an extract with a relative density of 1.15-1.5.

[0027] (4) Take the extract obtained in (3), add 5 times the qu...

Embodiment 2

[0036] Embodiment 2 (TQW to CCl 4 Protective effect of induced liver injury model rats)

[0037] CCl 4 The rat model of liver injury is currently recognized as an animal model of chemical liver injury, and this example is used to verify the protective effect of TQW on chemical liver injury.

[0038] 1. Grouping, modeling and administration

[0039] 60 rats were randomly divided into blank group, model group, bifendate group (positive control group) and TQW low, medium and high dose groups, and the rats in each group except the blank group were subcutaneously injected with 40% CCl 4 Olive oil solution 2mL / kg body weight, once every 2 days, a total of 6 injections, the first subcutaneous injection of 40% CCl 4 Olive oil solution 4mL / kg body weight, blank group subcutaneous injection of olive oil of equal volume;

[0040] From the first day of modeling, the TQW low-dose group was given TQW (15 mg / kg body weight) every day, the TQW middle-dose group was given TQW (30 mg / kg bod...

Embodiment 3

[0054] Example 3 (protective effect of TQW on ConA-induced liver injury model mice)

[0055] The mechanism of liver injury induced by ConA is similar to that caused by hepatitis virus. This example uses this model to verify the protective effect of TQW on liver injury caused by viral hepatitis.

[0056] 1. Grouping, modeling and administration

[0057] The mice were fed adaptively for 3 days after purchase, and 60 mice were randomly divided into blank group, model group, bifendate group (positive control group) and TQW low, medium and high dose groups;

[0058] In the morning and afternoon of the 4th day, in the morning and afternoon of the 5th day, and in the morning of the 6th day, intragastric administration or an equal volume of distilled water 0.2 mL / piece / time (the drug was diluted to an equal volume with distilled water), a total of 5 times. The TQW low-dose group was administered TQW (30 mg / kg body weight) each time, the TQW middle-dose group was administered TQW (60 ...

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Abstract

The invention discloses a compound Dai medicine extract with liver-protecting effect and a preparation method thereof. The compound Dai medicine extract is extracted from Dai medicines, such as Clerodendranthus spicatus (Thunb.)C.Y.Wu ex H.W.Li, Cassytha filiformis Linn. and Arcangelisia loureiri (Pier.)Diels. The invention also discloses a method for extracting the compound Dai medicine extract. The compound Dai medicine extract disclosed by the invention can be used for preparing liver-protecting medicines or health-care products.

Description

technical field [0001] The present invention relates to a kind of extract from Dai medicine Clerodendranthus spicatus (Thunb.) C.Y. Wu ex H.W.Li), rootless vine (Cassytha filiformis Linn.) and ancient mountain dragon (Arcangelisia loureiri (Pier.) Diels) A compound extract with significant hepatoprotective effect, a preparation method of the extract, a drug combination containing the extract, and the application of the extract and the drug combination as drugs and health products, especially for liver protection drugs and Preparation of health products. Background technique [0002] Liver injury is a common pathological state of many liver diseases, among which, liver injury caused by viral hepatitis, alcoholic liver injury and chemical liver injury caused by drugs and poisons are the most common, and long-term liver injury often leads to Hepatic fibrosis, even liver cirrhosis and liver cancer are important motivating factors. my country is a high-incidence area of ​​viral h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/59A61P1/16A23L1/29A23L33/00
Inventor 张春蕾韩莹李续博张岩姜醒王发善张宁
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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