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Novel application of rhizome alkaloids in the preparation of medicines for treating and/or preventing hyperlipidemia

A technology of hyperlipidemia and rootless rattan, which is applied in the field of preparation of rhizome water extract and rootless rattan alkaloids to treat and/or prevent hyperlipidemia, and achieves simple process, high safety, and reduced The effect of lipotherapy

Active Publication Date: 2019-11-22
GUANGXI WUZHOU PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There are currently no literature references to the Lauraceae lauraceae or radix alkaloids for the treatment and / or prevention of hyperlipidemia

Method used

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  • Novel application of rhizome alkaloids in the preparation of medicines for treating and/or preventing hyperlipidemia
  • Novel application of rhizome alkaloids in the preparation of medicines for treating and/or preventing hyperlipidemia
  • Novel application of rhizome alkaloids in the preparation of medicines for treating and/or preventing hyperlipidemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Take 10kg of rootless vines, soak in 30% ethanol for 30 minutes, heat and reflux for extraction twice, add 30% ethanol that is 7 times the weight of the medicinal material each time, extract for 2 hours each time, filter, combine the filtrates, add 1 % acetic acid solution, let it stand, filter, discard the precipitate, take the acid aqueous solution, extract 3 times with ethyl acetate, collect the acid aqueous layer, adjust the pH to 11 with 10% sodium carbonate solution, extract 3 times with chloroform, combine the chloroform solution, and recover Chloroform, anhydrous sodium sulfate drying, in the rootless vine alkaloid.

Embodiment 2

[0035] Get 10kg of rootless vines, soak in 50% ethanol for 30 minutes, heat and reflux for extraction 3 times, add 50% ethanol 6 times the weight of the medicinal material each time, extract for 1 hour each time, filter, combine the filtrates, add 1 % hydrochloric acid solution, let it stand, filter, discard the precipitate, take the acid aqueous solution, extract 3 times with dichloromethane, collect the acid aqueous layer, adjust the pH to 11 with 10% sodium carbonate solution, extract 3 times with chloroform, combine the chloroform solution, and recover Chloroform, anhydrous sodium sulfate drying, in the rootless vine alkaloid.

Embodiment 3

[0037] Take 10kg rootless rattan, take the rootless rattan, soak in 70% ethanol for 30 minutes, heat and reflux for extraction twice, add 70% ethanol that is 8 times the weight of the medicinal material each time, extract for 2 hours each time, filter, and combine Filtrate, add 1% hydrochloric acid solution to the filtrate, let it stand, filter, discard the precipitate, take the acid aqueous solution, extract 3 times with chloroform, collect the acid water layer, adjust the pH to 11 with ammonia water, extract 3 times with chloroform, combine the chloroform solution, and recover chloroform , dried over anhydrous sodium sulfate to obtain the alkaloids of the vine.

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Abstract

The invention relates to a new application of cassytha filiformis, namely, a new application of cassytha filiformis to preparation of medicine for treating and / or preventing hyperlipemia, in particular to a new application of cassytha filiformis aqueous extract and cassytha filiformis alkaloid to preparation of the medicine for treating and / or preventing hyperlipemia.

Description

technical field [0001] The present invention relates to the new application of the vine, especially the new application of the water extract of the vine and the alkaloid of the vine, that is, the new application in the preparation of medicines for treating and / or preventing hyperlipidemia. Background technique [0002] Hyperlipidemia is the main cause of various cardiovascular diseases, and the damage of the disease to the body is hidden, gradual, progressive and systemic. With the increase of blood lipids and the prolongation of abnormal blood lipids, it will cause atherosclerosis, coronary heart disease, hypertension, diabetes, stroke, fatty liver and other diseases. The incidence of these cardiovascular and cerebrovascular diseases is high, the harm is great, and the progress of the disease is dangerous. The mortality rate accounts for about half of the total human mortality. According to epidemiological statistics, the possibility of suffering from the onset of hyperlip...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/54A61P3/06
CPCA61K36/54A61K2236/331A61K2236/333A61K2236/39A61K2236/53A61K2236/55
Inventor 朱小凤刘冠萍吴赛春陈露林广莲招丽君
Owner GUANGXI WUZHOU PHARMA GRP
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