254 results about "Hepatoprotection" patented technology

The present invention relates to novel genipin derivatives which have an excellent liver protection activity with little cytotoxicity, and these compounds are so stable in vivo that they do not induce any side effects.

The present invention belongs to the field of medicine, and particularly relates to a novel curcumin pharmaceutical preparation, which comprises a solid dispersion, a micellar preparation, SMEDDS and a nanometer emulsion. According to the present invention, by increasing the solubility and the bioavailability of curcumin, the curcumin pharmaceutical preparation can effectively utilize the pharmacological effects of anti-oxidation, anti-inflammation, anti-cancer, apoptosis induction, antiangiogenesis, neuroprotection, anti-microorganism, liver and kidney protection, vascular formation inhibition, myocardial infarction prevention, blood glucose lowering, anti-rheumatism and the like of the curcumin.

The present invention relates to a compound of Antrodia camphorata used for liver protection, in particular to an extract, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone which is isolated from Antrodia camphorata. The cyclohexenone compound according to the invention helps to alleviate liver injury and fibrosis induced by chemicals and reduces the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). By increasing the contents of glutathione peroxidase (GSHPx) and catalase (CAT), cyclohexenone further decreases the liver damage and the oxidative pressure caused by free radicals, enhances the antioxidant ability and achieves the purposed of liver protection.

The invention discloses health products or drug combinations and preparation techniques and quality detection methods with functions of strengthening the stomach, nourishing the liver and improving the memory. The health products or drug combinations are composed of root kudzuvine, haw, malt, mum, mulberry leaf and lotus leaf. During preparing the health products or drug combinations, different components are processed by distillating, filtering, immersing, decocting, condensing, decompressing to make the effectine drug ingredients into full play. The invention also provides quality control methods for components identification and assay of the health products or drug combinations. The health products or drug combinations have functions of strengthening the stomach, nourishing the liver and improving the memory.

The invention discloses active dendrobe polysaccharide capable of protecting liver and resisting liver fibrosis, whose chemical structural formula is seen in the figure. The active dendrobe polysaccharide is gala glucomannan taking glucose and mannose as a main chain and galactose as a branch, the molecular weight of the gala glucomannan is about 2.2*104dalton, and the mole ratio of glucose to mannose to galactose in the composition is 31:10:8. The invention further discloses extraction, separation and purification methods of the active dendrobe polysaccharide as well as the preparation method of antibody affinity chromatography of the active dendrobe polysaccharide. The active dendrobe polysaccharide prepared by the method has remarkable physiological activity of protecting liver and resisting liver fibrosis and can be used for preparing liver-protecting health care products and medicines for curing liver fibrosis.

The present invention discloses a kind of flavone composition with the function of reducing the body damage caused by excessive indigestion of alcohol obviously, and the composition consists of pueraria flavonid and silybum marianum flavone. Research shows that pueraria flavonid and silybum marianum flavone have obvious cooperative effects of resisting oxidation, protecting liver and promoting elimination of alcohol in body. The present invention also discloses the application of the composition in health food and medicine.

The invention provides an anti-intoxication, alcohol-expelling and liver-protection preparation which has the functions of anti-intoxication, alcohol-expelling and auxiliary protection on alcoholic liver injury. The preparation consists of the following raw materials: 20-50 parts of vine tea, 5-15 parts of galangal, 10-40 parts of mung beans and 10-40 parts of poria cocos. The vine tea contains a great amount of flavonoid substances, and the dihydromyricetin in the vine tea has special effects in removing toxicity in alcohol, preventing alcoholic liver and fatty liver, inhibiting liver cell deteriorate, reducing the morbidity of liver cancer and protecting the liver. The galangal is acrid and hot in property, can enter the spleen and stomach channels, has the functions of eliminating cold to stop pain and warming the middle energy and stopping throwing and has a certain alcohol-expelling function, and moreover the flavonoid substance galangin in the galangal has a protection function on acute alcoholic liver injury. The poria cocos has the effects of clearing damp and promoting dieresis, tonifying spleen and quieting the heart, can promote the alcohol in bodies to discharge out along with urine, and is beneficial to sobering up. The mung beans have the effect of clearing away heat and toxic materials, can effectively relieve the symptoms of dizziness and unclear speaking after drinking alcohol, and furthermore has the pharmacologic action of protecting the liver and the kidney.

The invention discloses a moxa stick for improving brain health, which is characterized by comprising the following raw medicinal materials in parts by weight: 200 parts of folium artemisiae argyi, 1-5 parts of eaglewood, 5-15 parts of polygonum multiflorum, 1-5 parts of mulberry, 5-15 parts of dogwood, 10-20 parts of liquorice, 5-15 parts of sealwort, 4-8 parts of the bark of eucommia, and 4-8 parts of spina date seed. The invention further discloses a preparation method of the moxa stick. Because of being prepared by adding medicinal materials into folium artemisiae argyi, the moxa stick disclosed by the invention is safe, nontoxic and convenient to use, has the effects of stimulating the menstrual flow, activating collaterals, restoring consciousness, enlightening, reinforcing kidney, protecting liver, reducing internal heat and dispelling depression, is capable of improving brain health and preventing and treating brain diseases, and has good effects on a series of diseases caused by insufficient cerebral blood supply, such as cerebral infarction, cerebral arteriosclerosis, insufficient cerebral blood supply, infantile autism, depression and encephalatrophy; meanwhile, the moxa stick for improving brain health, which is disclosed by the invention, is capable of relieving emotion of people, reducing stress and improving sleep and has the obvious effect on psychiatric problems caused by tension and stress, such as schizophrenia.

The invention discloses a health product for protecting liver and a preparation method thereof. The health product for protecting liver is prepared from the following raw materials of: by weight, 1-5 parts of Dendrobium candidum, 3-8 parts of American ginseng and 12-20 parts of root of kudzu vine. It shows through pharmacological experiments that the health product provided by the invention has good effects of protecting liver, effectively raising liver function and promoting hepatocyte restoration and regeneration, has low adverse reactions, and is safe to take. According to the preparation method, the best preparation technology is determined according to physical and chemical property optimization of effective components of each raw material. The preparation method has strong operationality and is suitable for industrial production.

Disclosed is a composition for hepatoprotection, or for prevention or treatment of liver fibrosis or cirrhosis, which comprises as an active ingredient a water extract of a mixture of Trionycis Carapax, Raphani Semen, Artemisia capillaris Herba, Atractylodis Macrocephalae Rhizoma, Poria cocos, Alismatis Rhizoma, Atractylodis Rhizoma, Salvia Miltiorrhizae Radix, Polyporus, Amomi Fructus, Ponciri Fructus, Glycyrrhizae Radix and Helenii Radix.

The invention relates to the application of a compound to treating hepatitis and aims at providing an isochlorogenic acid compound which has stronger effects of anti-HBV, anti-inflammation and liver protection, and has wide and rich sources, and simple and convenient extraction process. The technical proposal is as follows: the isochlorogenic acid compound is made from one or more than one of isochlorogenic acid A, isochlorogenic acid B and isochlorogenic acid C according to any mixture ratio; in addition, the technical proposal further comprises the application of the compound to preparing drugs for resisting hepatitis B virus, and resisting inflammation and protecting liver.

The invention discloses a hepatoprotectivespace Lactobacillus plantarum FH-SS18--86365L and an application thereof. The preservation number of the Lactobacillus plantarum FH-SS18--86365L is No. CGMCCNo. 16124. The invention also protects the plant Lactobacillus SS18-86365L is a bacterial agent of active ingredient. The invention also protects Lactobacillus plantarum SS18-86365L or that use of themicrobial agent in the preparation of the product. The use of the product is for the treatment and / or prevention of fatty liver. The use of the product is to treat and / or prevent hyperlipidemia. Theuse of the product is to protect the liver. The Lactobacillus plantarum SS18-86365L has that effect of protecting live and inhibiting the formation of fatty liver, and has wide market application prospect.

The invention discloses new medical application of glycyrrhiza inflata ethanol extract and licochalcone A. The inventor discovers that glycyrrhiza inflata and other medical licorice root have obvious chemical ingredient difference, furthermore systematically researches the glycyrrhiza inflata ethanol extract and the important ingredient licochalcone A therein, and discovers that the glycyrrhiza inflata ethanol extract and the licochalcone A have remarkable activity in protecting oxidized cell injury, tissue injury and acute chemical liver injury. Based on the discovery, the extract and an active compound or pharmaceutically acceptable salt, ester and a solvate, a stereoisomer, tautomer, a prodrug and a mixture thereof can be used for preparing medicaments and health products for treating / preventing oxidative injury and / or acute chemical liver injury.

The invention relates to the preparation of phenolics derivatives by enzymatic condensation of phenolics selected among pyrocatechol or its derivatives with the glucose moiety of sucrose. The production of said phenolics derivatives is achieved with a glucosyltransferase (EC 2.4.1.5). These O-α-glucosides of selected phenolics are new, have a solubility in water higher than that of their parent polyphenol and have useful applications in cosmetic and pharmaceutical compositions, such as antioxidative, antiviral, antibacterial, immune-stimulating, antiallergic, antihypertensive, antiischemic, antiarrythmic, antithrombotic, hypocholesterolemic, antilipoperoxidant, hepatoprotective, anti-inflammatory, anticarcinogenic, antimutagenic, antineoplastic, anti-thrombotic and vasodilatory formulations, or in any other field of application.

The invention discloses an olive total phenylethanoid glycoside composition. The olive total phenylethanoid glycoside composition comprises 6 types of particular phenylethanoid glycoside compositions which include cistanoside E, calcelarioside B, verbascoside, isoverbascoside, forsythoside B and alyssonoside and are varied from a general formula A. Pathological tests show that the olive total phenylethanoid glycoside composition in the general formula A has good anti-liver fibrosis and liver protection effects, can be used as an active ingredient of medicines for resisting liver diseases, canbe independently used or combined with proper excipients and the like, and is prepared into oral or non-oral dosage forms by conventional methods to be used for preparing medicines for treating liverdiseases.

The invention relates to the technical field of medicines. Chalcone is a natural component in plants and has antibiotic and antifungal effects, and derivatives of the chalcone also have the effect of resisting tumors and the like. At present, no document is reported that the derivatives of the chalcone have the effect of reducing activity of blood fat and protecting the liver. The invention provides derivatives of the dihydrochalcone having a general formula I. Through tests of reducing blood fat, the results show that the derivatives of the dihydrochalcone have the effects of obviously reducing serum total cholesterol and low-density lipoprotein cholesterol, and can be used to prepare medicines or health products for reducing blood fat, preventing and treating hyperlipoidemia, fatty liver, hepatocirrhosis and atherosclerosis and protecting the liver.

The invention relates to a method for the treatment or prevention of diseases or conditions associated with vascular endothelium dysfunction or liver injury comprising the administration to a patient in a need of such treatment or prevention of a therapeutically or prophylactically effective amount of a compound selected from the group consisting of:wherein R represents hydrogen atom, CH3, OH, pyridyl (C5H4N), 1-methylpyridyl (C5H4N—CH3) or pyridyl substituted with hydroxy group ((OH)C5H3N), and X represents a physiologically acceptable counterion.

The invention discloses a ring-A polyoxidizing substituted glycyrrhetinic acid derivative and a preparation method and application thereof. The compound has the formula shown in the specification, wherein R1 is selected from carbonyl or hydroxyl; R2 and R3 are hydroxyl or an epoxy group exists between R2 and R3; R4 is selected from -COOH, -COOR1, -CONH2, -CONHR1 and -CONR1R2; R1 and R2 are selected from alkyl with 1-15 carbon atoms, substituted or unsubstituted phenyl, substituted or unsubstituted phenyl alkyl, and R1 and R2 can be same or different; Y is CH2 or C=O; hydrogen in the 18th site is alpha or beta-configuration; when R1, R2 and R3 are hydroxyl, the hydroxyl substituent configurations can be alpha or beta-configurations. The compound with a novel structure, which is provided by the invention, and the salt thereof have relatively strong hepatoprotective activity and can be used for preparing hepatoprotective medicines. The derivative has the application of resisting bacteria or tobacco mosaic virus, and has good application prospects in the fields of medicines and pesticides.

The present invention is one kind compound Chinese medicine preparation for protecting liver and treating various hepatopathy and its preparation process and quality control method. The compound preparation consists of water soluble silybin derivative silybin meglumine and total arasaponin as the effective components of notoginseng in the weight ratio of 1 to 0.2-2. It is prepared into injection through dissolving, adding polyglycol or propylene glycol as co-solvent, filtering, ultrafiltering and packing; or into powder for injection through dissolving, adding mannitol or glucose as forming agent, filtering, ultrafiltering and freeze drying. Its contents of silybin and total arasaponin and its fingerprint are determined via HPLC process. The compound preparation of the present invention has curative effect obviously higher than its single components, and has the features of high curative effect and high safety.

An application of human s DR5 protein in preparing the medicines for treating the viral hepatitis B, especially the acute severe viral hepatitis B, by protecting liver cells and preventing the wither of liver cells is disclosed.

The invention relates to a novel compound, pharmaceutical compositions thereof as well as preparation methods thereof and use of the novel compound and the pharmaceutical compositions, and belongs to the field of pharmacy. The novel compound is oleanolic acid amino glucoside and pharmaceutically acceptable salts. A physical and chemical constant test displays that the solubility of the novel compound is enhanced by tens to hundreds of times in comparison with that of the oleanolic acid. An experiment verifies that the novel compound and the pharmaceutical compositions have more excellent effects than the oleanolic acid in the aspects such as blood pressure reduction, tumor resistance, liver protection and reduction of blood fat.

The present invention relates to a pharmaceutical composition useful as a hepatoprotective agent, said composition comprising of a mixture of coumarinolignoids of formula 1,2 and 3. The present invention also relates to a improved process for production of liver protective composition containing coumarinolignoids of formula 1, 2 and 3 from Cleome viscosa with optimized ratios of the same. More particularly, the present invention relates to a processing technology for the isolation of a combination of coumarinolignoids Cliv-92 comprising a mixture of coumarinolignoids of formula 1,2 and 3 from the seeds of Cleome viscosa.

The invention relates to the extracting technics of the amylase of the privet and the astragalus and the production and the appliance. The amylose is gained from the extracting and retreated the active ingredient amylose of the privet and the astragalus root; the extracting technics is easy and reasonable; the cost is cheap; the gained production is tested to be the glossy privet fruit amylose and the astagalus root amylose; the production has the function of boosting up the body immunologic function and boosting the cell metabolize, regulating the composing of the rna, the deoxyribonucleic acid and the albuminoid, reinforcing the kidney and nourishing the liver; at the same time , it has other function of the antivirus, resisting the knub, fighting against senium, resisting the radiste, resisting the stress, the oxidation resisting ; it can be use to improved the body immunologic function and protect the function of the marrow and the adrenocrtication and cure the disease due to asthenia of viscera and cooperate the operation, radistion therapy, the chemic therapy and accelerate the resume of the positive function and the prevention and treatment of the hepatitis, the diabetes, the flu, the cerebral thrombosis clinically.

The invention discloses semen hoveniae extracts with a liver protection function and an extraction and separation method and application thereof. The extracts comprise, by mass, 10-99% of total flavone C-glycoside, wherein the main flavone C-glycoside comprises six kinds of flavone C-glycoside including vitexin 2''-O-beta-D-glucopyranoside, spinosin, poloretin-3', 5'-di-C-beta-D-glucopyranoside, 6'' '-acetyl spinosin, 6'' '-p- hydroxyl-cinnamoyl-spinosin and 6'' '- sinapoyl-spinosin. The total flavone C-glycoside is extracted from semen hoveniae and used for preventing and treating acute and chronic hepatitis and alcoholic liver disease; compositions at effective parts are accurate; toxicity is small; the pharmacological action is high, and a good medicine prospect is achieved. The extracts and acceptable agents on pharmacy are adopted to be prepared into various dosage forms through a conventional method, like tablets, pills, capsules and granules. The dosage is 200-800 mg / each person / day.

The invention provides application of a compound shown in a general formula I in preparing a hepatic or health-care food. The invention also provides a pharmaceutical composition containing the compound shown in the general formula I. The medicament belongs to a pure natural preparation, is safe and reliable, is developed from food, has small toxicity, and has no adverse reaction after being usedfor a long time; the medicament can be drunk as tea, and has convenient use and delicious taste; the medicament has protection effect on hepatic injury caused by various reasons, and has prevention and treatment effects on various diseases caused by the hepatic injury; and the medicament has good effect on treating or preventing acute alcoholism, and can obviously improve various symptoms caused by alcoholic intoxication such as dizziness, headache, hypodynamia and the like.

The invention discloses new application of phillyrin, phillyrin derivatives, and a phillyrin-phillygenin composition in preparation of drugs or health products for liver protection, liver care and liver injury resistance. Tests prove that the phillyrin, phillyrin derivatives, and phillyrin-phillygenin composition have the characteristics of significant liver protection, liver care and liver injury resistance effect, quick effect and small toxic and side effect, are a safe, efficient and stable liver protection and liver injury resistance drug with a simple preparation process, and are suitable for industrial production and easy for popularization. The invention provides a new drug source for liver protection and liver injury resistance.

This invention relates to applications of Chinese starjasmine stem aglycon, burdock aglycon and Chinese starjasmine stem glucoside as dibenzyl butyrolactone compounds to the preparation of medicaments for treating hepatitis viruses and particularly hepatitis C viruses. The three compounds can be also used for preparing liver protection food or healthcare product. The invention provides the new applications of the Chinese starjasmine stem aglycon, the burdock aglycon and the Chinese starjasmine stem glucoside. The study on tests on resisting hepatitis C viruses shows that the three compounds have very significant hepatitis C virus resisting activity and can serve as the sources of novel active components for developing the medicaments for resisting hepatitis viruses, the liver protection food and the healthcare product.

The invention relates to an amino acid composition capable of protecting kidney and liver as well as promoting growth for the animal. The amino acid composition comprises the raw materials: 95% of tea polyphenol, propolis powder, Japanese climbing fern spore, herba lysimachiae, taurine, glutathione, coated vitamin, vitamin, etc. The amino acid composition capable of protecting kidney and liver as well as promoting growth for the animal can be used as prophylactic medicine for health protection and curative medicine for treating disease, so as to effectively protect the kidney and the liver of the animal, alleviate or eliminate drug-induced liver and kidney damage of animal, strength the functions of detoxification and metabolism of the liver as well as excretory function of the kidney, lead the drug effect to be improved, reduce the dosage, effectively shorten course of disease and increase the cure rate of diseases.

The invention provides a traditional Chinese medicine composition capable of protecting livers and reducing lipid. The traditional Chinese medicine composition is characterized by comprising, in partsby weight, 1-100 parts of herba sedi, 1-100 parts of seaweeds, 1-100 parts of calcined oyster shells, 1-100 parts of hawthorns, 1-100 parts of alcohol-treated Herba Siegesbeckiae, 1-100 parts of vinegar-added Schisandra chinensis and 1-100 parts of rhizoma polygoni cuspidati. Through the composition, the content of triglyceride, total cholesterol and low-density lipoprotein-cholesterol (P<0.05) in liver-disease model rats can be reduced significantly, the level of high-density lipoprotein-cholesterol (P<0.05) is increased significantly, and it is shown that the prepared composition has the effect of treating non-alcoholic steatohepatitis. Moreover, it is also confirmed through experiments that the traditional Chinese medicine composition is capable of reducing the activity of glutamic-pyruvic transaminase and glutamic-oxalacetic transaminease in serum and the secretion amount of IL-6 in the liver tissue of the model rats significantly, and it is also shown that the traditional Chinesemedicine composition has a significant protective effect on rat liver injury caused by CC14.

At least one isolated lactic acid bacteria strains selected from the following: TSP05 (Lactobacillus plantarum), TSF331 (Lactobacillus fermentum) and TSR332 (Lactobacillus reuteri) is provided. The above-mentioned active or inactive lactic acid bacteria strains have a function of hepatoprotection and is used in a form of a food composition or a pharmaceutical composition.