16 results about "Hepatoprotection" patented technology

This invention discloses the application of American ginseng glycoprotein extract in the preparation of drugs for treating alcoholic liver disease, belonging to the field of biomedical technology. This invention verifies that TD can significantly reduce serum ALT, AST, and TG levels in ALD mice, effectively reducing liver damage and lipid accumulation; inhibit NLRP3 protein expression and its downstream targets, effectively alleviating liver inflammation and pyroptosis; and improve intestinal flora imbalance in ALD mice. American ginseng glycoprotein extract has multi-target protective effects against alcoholic liver disease, reducing alcohol-induced liver tissue inflammation and oxidative stress damage. It has a mild composition and high safety profile, and can synergistically exert effects in liver protection, anti-inflammation, and antioxidation, making it suitable for adjunctive intervention and long-term management of alcoholic liver disease, providing a natural, mild, and effective protective pathway for alcoholic liver damage.

The application provides a curcumin composition-FGF21 functional protein co-assembly microparticle applied to liver diseases and a preparation method thereof, and comprises the following steps: extracting turmeric by dynamic warm soaking, obtaining turmeric filtrate after centrifugation, concentration and microfiltration; preparing high-purity curcumin composition through PS-NVP specific purification and 80% ethanol gradient elution; and preparing Curs-FGF21 co-assembly microparticles through oil-water phase assembly and centrifugation by taking a polymer as a carrier, compounding the curcumin composition with FGF21 protein. The microparticle can improve drug stability and bioavailability, realizes long-acting slow release, can regulate liver cell lipid metabolism, reduce liver lipid accumulation and inflammation, significantly improves liver damage and liver fibrosis, and has outstanding liver protection and repair effects. The process is stable and controllable, has outstanding innovation, and provides a brand-new candidate preparation research and development idea and technical scheme for the prevention and treatment of metabolic liver diseases.

The application discloses a near-infrared carbon monoxide fluorescent probe and a preparation method and application thereof, wherein the probe has a structure shown in formula I; a fluorescent unit of the probe is constructed by connecting 2-pyridine acetonitrile and hydroxyl xanthene derivative through an olefin bond; the probe itself has weak fluorescence and can release strong near-infrared fluorescence signals after responding to carbon monoxide. The probe has the advantages of rapid response, high sensitivity and good selectivity. The probe can sensitively detect expression changes of endogenous carbon monoxide levels, realize direct diagnosis of pathological degrees of drug-induced liver injury, and realize visual evaluation of liver-protecting effects of active components of traditional Chinese medicines. The application integrates disease diagnosis and drug efficacy evaluation functions in a single probe system, and provides an efficient and intuitive molecular imaging tool for early warning of drug-induced liver injury and screening of liver-protecting components of traditional Chinese medicines.

The present application belongs to the field of nutritional composition and biological medicine technology, and particularly relates to a composition for protecting and preserving liver, a preparation method, application and product thereof. The composition of the present application is composed of extract of Silybum marianum, glucoraphanin and extract of Cynara scolymus. The composition of the present application can intervene the pathological process of liver injury from multiple dimensions such as antioxidation, anti-inflammation, regulation of lipid metabolism and repair of hepatocytes through synergistic effect of the three components, significantly reduces the levels of glutamic-pyruvic transaminase and glutamic-oxalacetic transaminase, reduces the accumulation of liver fat, improves the antioxidant capacity of the body, effectively prevents or improves alcoholic, chemical, non-alcoholic fatty and autoimmune liver injury, delays the progression of liver fibrosis, and comprehensively maintains the structural integrity and functional stability of the liver.

The application discloses application of a triperpenoid compound of Ailanthus-type or a glycoside thereof in preparation of a liver-protecting medicine. The application also performs glycosylation modification on the triperpenoid compound of Ailanthus-type to obtain a liver-protecting active triperpenoid glycoside of Ailanthus-type. The compound has potential application value in preparation of a medicine for preventing or treating liver diseases.

The application relates to the field of medicine, in particular to the application of 4-hydroxyphenylacetic acid and irinotecan as cancer chemotherapy drugs. In view of the technical defects that the existing irinotecan chemotherapy hepatoprotective drugs have single action and may interfere with the chemotherapy effect, the application provides the application of 4-hydroxyphenylacetic acid and irinotecan in the preparation of cancer chemotherapy drugs. The application has the following advantages: 1. clear hepatoprotective effect: 4HPAA can significantly alleviate the liver fatty degeneration induced by irinotecan; 2. significant synergistic anti-tumor effect: the tumor inhibition effect of the combination of 4HPAA and irinotecan is significantly better than that of the single-drug group; 3. high safety; and 4. great clinical transformation potential.

The application of mussel polysaccharide in preparation of a medicine for regulating the intestine-liver axis to treat alcoholic liver injury belongs to the technical field of natural products and biological medicine. The method takes mussel polysaccharide as an active ingredient, and divides experimental mice into a normal control group, an alcoholic liver injury model group, a positive control group and mussel polysaccharide low-, medium- and high-dose groups (60, 120 and 180 mg / kg / day), and continuously intervenes for 4 weeks. The results show that the mussel polysaccharide can significantly reduce liver function indexes such as ALT and AST, improve TC, TG, LDL-C, HDL-C related blood lipid disorders, protect the colon mucosal barrier, regulate the intestine-liver axis homeostasis, effectively reduce alcohol-induced liver fatty degeneration, inflammatory infiltration and oxidative stress injury, and the effect shows obvious dose dependence. The mussel polysaccharide is safe, non-toxic, economical in source, simple in intervention method and strong in repeatability, and provides a new way for the development of functional food and liver protection products for preventing and treating alcoholic liver injury.

The application discloses a rhynoxanthine type diterpene and a preparation method and application thereof; the rhynoxanthine type diterpene is separated from the bark of Cinnamomum cassia, and has at least one of structural formulae as shown in formula (I), formula (II) and formula (III); the rhynoxanthine type diterpene is separated from the bark of Cinnamomum cassia in the Lauraceae Cinnamomum plant; the application uses an alcohol, palmitic acid and other induced liver cell damage models to evaluate hepatoprotective activity, finds that the rhynoxanthine type diterpene can effectively relieve alcohol, palmitic acid and other induced liver cell damage, and indicates that the rhynoxanthine type diterpene has hepatoprotective activity, can be used for preparing hepatoprotective drugs, and has a good research and development prospect.

The application discloses use of Acorus gramineus or an extract thereof in preparation of a medicine for treating and / or preventing diseases caused by liver injury and use in preparation of a medicine for treating and / or preventing diseases and / or conditions related to diseases caused by liver injury. The diseases caused by liver injury can be acute liver injury, chronic liver injury, liver fibrosis, liver cirrhosis, liver cancer and the like. The Acorus gramineus or the extract thereof has a liver protection effect, and proves to have a protective effect on the diseases caused by liver injury through liver function indexes and liver pathological staining, and is expected to become a new therapeutic drug for liver injury diseases.

The application discloses application of a combination of lyophilized powder of Haemadipsa integrifascialis and bear gall powder in preparation of a medicine for treating liver injury, and belongs to the technical field of medicines. The application proves through in-vitro HepG2 and HSC-T6 cell experiments and in-vivo CCl4-induced mouse liver injury models that the combination of the lyophilized powder of Haemadipsa integrifascialis and the bear gall powder can significantly improve the survival rate of injured liver cells, inhibit the activation and fibrosis of hepatic stellate cells, reduce the level of inflammatory factors, improve the antioxidant capacity, reduce the pathological injury of liver tissues, and the synergistic effect is significantly better than that of single medicine, and the safety is good. The application provides a new medicine combination and experimental basis for developing a new liver-protecting and anti-liver fibrosis medicine, and has important clinical application and medicine development values.

The invention relates to the technical field of bioactive polypeptides and liver health regulation, in particular to a polypeptide with a liver protection function. The polypeptide achieves the liver protection effect by inhibiting inflammatory response and protecting liver cell activity, the effect of the polypeptide does not depend on a single induction factor, and the polypeptide can play a stable and remarkable protection role in different types of liver injury models, which indicates that the polypeptide has broad-spectrum liver protection potential. Compared with the existing micromolecular anti-inflammatory or anti-oxidation liver protection preparation, the polypeptide disclosed by the invention is safe in source, low in toxic and side effects, clear in activity, suitable for being developed into functional foods, medicines or health-care preparations for preventing and treating liver injury, hepatitis and inflammation-related liver diseases, and good in application prospect and industrialization value.

This invention discloses the application of a renolane-type diterpenoid compound or a pharmaceutically acceptable salt thereof in the preparation of a drug for the prevention or treatment of liver disease; the renolane-type diterpenoid compound has at least one of the structural formulas shown in formulas (I), (II), (III), (IV), (V), and (VI); the renolane-type diterpenoid compounds of formulas (I) to (VI) can significantly alleviate alcohol-induced hepatocellular damage, and the renolane-type diterpenoid compounds of formulas (III) to (VI) can significantly alleviate palmitic acid-induced hepatocellular damage, indicating that the renolane-type diterpenoids of this invention have hepatoprotective activity and can be used to prepare hepatoprotective drugs, showing good research and development prospects. This invention belongs to the field of natural product chemistry.

The present invention discloses a natural plant liver-protecting formulation based on promoting bile secretion and a preparation thereof, relating to the technical field of natural plant medicine and health food. The present invention effectively achieves a liver-protecting effect through multi-target synergistic actions of promoting bile secretion, cholagogic and detoxifying effects, and directly protecting liver cells. Among these, the milk thistle extract is rich in silymarin, which can stabilize hepatocyte membranes, prevent toxic substances from entering hepatocytes, and promote the repair and regeneration of damaged hepatocytes. Cynarin in the artichoke extract promotes bile secretion, accelerates the excretion of toxins and waste from the body, and reduces the burden on the liver. The total flavonoids component in the dandelion root extract has anti-inflammatory and antioxidant effects, which can protect hepatocytes from free radical damage, thereby comprehensively improving liver health.

This invention discloses the application of a traditional Chinese medicine composition in the preparation of drugs, foods, or health products for the prevention and / or treatment of Alzheimer's disease and / or neuroinflammation and / or cognitive impairment. The traditional Chinese medicine composition includes Hovenia dulcis, mung bean, sea buckthorn or fresh sea buckthorn, tangerine peel, mulberry or fresh mulberry, turmeric, and hawthorn. It exhibits good preventive and therapeutic effects on Alzheimer's disease, improves neuroinflammation, and alleviates cognitive impairment. It can effectively avoid the toxic effects of acetaldehyde on the human body, achieve the prevention of drunkenness and rapid sobering up. It has good improvement effects on alcoholic liver damage, alcoholic gastric damage, alcoholic kidney damage, alcoholic brain damage, alcoholic cardiomyopathy, and alcohol-induced cognitive impairment. It also has the effects of protecting the cardiovascular and cerebrovascular systems, strengthening the spleen and stomach, and protecting the liver. It has the advantages of having a small number of medicinal ingredients, low cost, convenient administration, no obvious toxic side effects, and convenient daily carrying. It is suitable for timely administration by people who want to sober up and for preventive health care by the general population. Its market prospects are even broader.