46 results about "Hepatoprotection" patented technology

The invention provides an antrodia camphorata sporocarp extract, which is prepared from the following raw materials in parts by weight: 20 to 24 parts of wild ganoderma lucidum extract, 8 to 12 parts of herba taraxaci and 8 to 12 parts of bolete. The antrodia camphorata sporocarp extract disclosed by the invention contains various physiologically active components such as triterpenoids, polysaccharides, superoxide disproportionated enzymes, adenosine, proteins (containing immune proteins), vitamins, trace elements, nucleic acid, lectin, amino acid, sterols, lignin, blood pressure stabilizing substances and the like; the traditional Chinese medicine composition can relieve various tumors such as hangover, gastrointestinal discomfort, heatstroke, hypertension, virus infection, diabetes mellitus, nephritis, liver cirrhosis and liver cancer, has the effects of resisting oxidation, resisting inflammation, inhibiting hypertension, protecting liver nerves, inhibiting tumor growth and the like, can bidirectionally regulate immunity and protect the liver, can also treat tumors at multiple targets, and has a wide application prospect. The discomfort of a patient in an anti-tumor process is reduced.

The invention belongs to the technical field of biological medicines, and provides a method for synthesizing testosterone 17-O-beta-D-glucosyl-(1-> 4)-6 ''-O-acetyl-beta-D-glucoside through two-step enzymatic coupling. Mainly relates to an intermediate compound testosterone 17-O-beta-D-glucosyl-(1-> 4)-beta-D-glucoside for synthesizing the molecule, mutant amino acid and nucleotide sequences of glycosyl transferase OsSGT2 for synthesizing the intermediate, and synthesis application. In addition, the invention also provides an application of the testosterone 17-O-beta-D-glucosyl-(1-> 4)-6 ''-O-acetyl-beta-D-glucoside in liver protection.

The present application relates to the technical fields of oligosaccharide preparation, and discloses a preparation method of dendrobium huoshanense oligosaccharide with liver protection activity, and the specific steps are as follows: first, fresh dendrobium huoshanense stems are selected, impurities are removed, and low-temperature drying is performed, then deionized water is added and heated to extract dendrobium crude polysaccharide; then the crude polysaccharide solution is refined to obtain dendrobium refined polysaccharide; then beta-mannanase is added to the dendrobium refined polysaccharide extraction solution for enzymolysis, the polysaccharide solution is removed through a molecular cut-off membrane, and dendrobium huoshanense oligosaccharide stock solution concentrate is obtained; finally, the finished product is obtained through freeze-drying. The preparation method is simple, efficient and pollution-free, and the prepared dendrobium huoshanense oligosaccharide has significant effects in liver protection.

This invention discloses the application of American ginseng glycoprotein extract in the preparation of drugs for treating alcoholic liver disease, belonging to the field of biomedical technology. This invention verifies that TD can significantly reduce serum ALT, AST, and TG levels in ALD mice, effectively reducing liver damage and lipid accumulation; inhibit NLRP3 protein expression and its downstream targets, effectively alleviating liver inflammation and pyroptosis; and improve intestinal flora imbalance in ALD mice. American ginseng glycoprotein extract has multi-target protective effects against alcoholic liver disease, reducing alcohol-induced liver tissue inflammation and oxidative stress damage. It has a mild composition and high safety profile, and can synergistically exert effects in liver protection, anti-inflammation, and antioxidation, making it suitable for adjunctive intervention and long-term management of alcoholic liver disease, providing a natural, mild, and effective protective pathway for alcoholic liver damage.

The invention belongs to the technical field of biology, and discloses application of DVM nanoparticles in preparation of products for treating and / or preventing alcoholic liver diseases, the DVM nanoparticles contain gallic acid derivatives VM and dihydromyricetin; the mass ratio of the gallic acid derivative VM to the dihydromyricetin is 1: 3; in alcohol-induced HepG2 cells, the DVM nanoparticles can better reduce apoptosis of hepatocytes and generation of ROS, improve ADH activity, reduce AST and ALT activities in the cells and improve the hangover alleviating ability in mice, and have a more excellent liver protection effect compared with gallic acid and a positive drug silibinin.

The invention discloses a rosa roxburghii tratt fruit composite beverage with a hangover alleviating effect and a preparation method and application thereof, and belongs to the technical field of biology. The roxburgh rose beverage disclosed by the invention comprises the following raw materials in parts by weight on the basis of 100 parts by weight: 8-16 parts of roxburgh rose concentrated juice, 5-15 parts of crystalline fructose, 0.8-2.5 parts of soybean peptide powder, 0.8-1.8 parts of yeast extract and the balance of water. Experiments prove that the formula product has the advantages of moderate taste, aromatic flavor, good stability and the like, and can keep stable taste and flavor during long-term storage. Animal experiments verify that the roxburgh rose beverage has an obvious hangover alleviating effect by improving ALDH activity, accelerating ethanol metabolism and reducing blood ethanol mass concentration, can improve liver injury caused by drinking by increasing liver SOD, GSH-Px, CAT activity and GSH content, reducing MDA content, enhancing body antioxidant ability and inhibiting lipid peroxidation reaction, and has a liver protection effect.

The invention discloses an acacetin and isonicotinamide eutectic, a preparation method, a composition and application thereof, and belongs to the technical field of medicines. Specifically, the invention discloses an eutectic substance formed by acacetin and isonicotinamide, and the molecular formula of the eutectic substance is (C16H12O5). (C6H6N2O), the invention relates to a preparation method of a cocrystal of acacetin and isonicotinamide. The acacetin and isonicotinamide eutectic is used as an active ingredient of a medicine and is applied to preparation of medicines for resisting oxidation, resisting inflammation, resisting viruses, resisting tumors, resisting rheumatism, easing pain, protecting the liver, regulating immunity, treating osteoporosis and treating cardiovascular and cerebrovascular diseases.

The application provides a curcumin composition-FGF21 functional protein co-assembly microparticle applied to liver diseases and a preparation method thereof, and comprises the following steps: extracting turmeric by dynamic warm soaking, obtaining turmeric filtrate after centrifugation, concentration and microfiltration; preparing high-purity curcumin composition through PS-NVP specific purification and 80% ethanol gradient elution; and preparing Curs-FGF21 co-assembly microparticles through oil-water phase assembly and centrifugation by taking a polymer as a carrier, compounding the curcumin composition with FGF21 protein. The microparticle can improve drug stability and bioavailability, realizes long-acting slow release, can regulate liver cell lipid metabolism, reduce liver lipid accumulation and inflammation, significantly improves liver damage and liver fibrosis, and has outstanding liver protection and repair effects. The process is stable and controllable, has outstanding innovation, and provides a brand-new candidate preparation research and development idea and technical scheme for the prevention and treatment of metabolic liver diseases.

The invention discloses a high-efficiency targeted anti-hepatic fibrosis oral nano drug delivery system and a preparation method thereof. According to the system, a sesquiterpene lactone component, namely lettuce lactone (LC), in Xinjiang traditional liver protection medicinal material cichorium glandulosum is used as a medicine core, and although the lettuce lactone has a good anti-fibrosis effect, the lettuce lactone (LC) has the problems of poor water solubility, high first-pass metabolism and the like. Therefore, 18 beta-glycyrrhetinic acid modified silicon-based hybrid micelles (LC-FS-G) are studied and constructed, the liver targeting property of glycyrrhetinic acid and a silicon-based cross-linked structure are utilized to enhance the stability, and drug release is responded in a glutathione (GSH) high expression environment by virtue of a disulfide bond. The particle size of the obtained micelle is uniform (27.83 nm), the encapsulation efficiency reaches 95.05%, and the drug loading rate is 10.62%. The system is slowly released in gastric juice (48h release lt); 50%), and the gt can be quickly released in a high GSH environment (36h release gt; 87%), and the liver fibrosis process can be reversed by regulating and controlling a TGF-beta / Smad pathway. According to the strategy, physicochemical and metabolic restrictions of LC are overcome, and a new way with high efficiency and low toxicity is provided for oral nano targeted therapy of hepatic fibrosis.

This invention relates to the field of traditional Chinese medicine technology, specifically to a composition for clearing heat and detoxifying, protecting the liver and improving eyesight, its pharmaceutical preparation and application. The raw materials of the composition, by weight, include the following components: 10-30 parts ursodeoxycholic acid, 1-5 parts chenodeoxycholic acid, 5-15 parts Lycium barbarum polysaccharide, 5-18 parts betaine, 1-5 parts glycyrrhizic acid, 0.2-5 parts glycyrrhetinic acid, and 1-5 parts glycyrrhizin. This invention combines these components to achieve the effects of clearing heat and detoxifying, protecting the liver and improving eyesight. Pharmacological experiments have demonstrated that it has significant antipyretic effects, prevents and treats eye fatigue, and improves acute liver injury.

The invention discloses a nutrition intervention composition with functions of regulating liver metabolism, promoting liver repair and resisting hepatic fibrosis. The nutrition intervention composition comprises purple perilla micro-capsule powder, a protein component, a liver peptide component, glutathione-rich yeast, a silybum marianum component, corn oligopeptide powder, oat powder and a fermentation product of germinated brown rice powder. According to the nutrition intervention composition disclosed by the invention, the microencapsulated perilla frutescens extract is organically integrated with antioxidant, regeneration-promoting and metabolism-regulating components such as a protein component, a liver peptide component, glutathione-rich yeast, a silybum marianum component and corn oligopeptide, so that the stability and bioavailability of fat-soluble active components are improved; the functions of exogenous anti-oxidation, endogenous anti-oxidation supplement, hepatocyte repair and intestinal-hepatic axis regulation are synergistically enhanced, so that the synergistic and lasting liver protection, repair and anti-fibrosis effects are realized.

The application discloses a near-infrared carbon monoxide fluorescent probe and a preparation method and application thereof, wherein the probe has a structure shown in formula I; a fluorescent unit of the probe is constructed by connecting 2-pyridine acetonitrile and hydroxyl xanthene derivative through an olefin bond; the probe itself has weak fluorescence and can release strong near-infrared fluorescence signals after responding to carbon monoxide. The probe has the advantages of rapid response, high sensitivity and good selectivity. The probe can sensitively detect expression changes of endogenous carbon monoxide levels, realize direct diagnosis of pathological degrees of drug-induced liver injury, and realize visual evaluation of liver-protecting effects of active components of traditional Chinese medicines. The application integrates disease diagnosis and drug efficacy evaluation functions in a single probe system, and provides an efficient and intuitive molecular imaging tool for early warning of drug-induced liver injury and screening of liver-protecting components of traditional Chinese medicines.

The invention relates to the technical field of traditional Chinese medicine preparations, and discloses a preparation method of a liver-protecting and hangover-alleviating formula containing radix puerariae, turmeric, hovenia dulcis thunb and penthorum chinense pursh, and the liver-protecting and hangover-alleviating formula is prepared from the following raw materials in parts by weight: 20-40 parts of radix puerariae, 15-30 parts of turmeric, 10-25 parts of hovenia dulcis thunb and 10-25 parts of penthorum chinense pursh. According to the preparation method of the liver-protecting and hangover-alleviating radix puerariae, turmeric, hovenia dulcis thunb and penthorum chinense pursh, based on the theory of traditional Chinese medicine and modern pharmacological research, radix puerariae, turmeric, hovenia dulcis thunb and penthorum chinense pursh are scientifically matched, and radix puerariae has the effects of resisting oxidation and promoting alcohol metabolism; turmeric is anti-inflammatory and anti-oxidative stress; hovenia dulcis thunb inhibits alcohol absorption and protects liver cell membranes; penthorum chinense pursh has the effects of detoxifying, resisting inflammation and protecting the liver, the four medicines are combined to achieve a multi-target and multi-path synergistic effect, the powerful effects of protecting the liver and relieving alcoholism are jointly achieved, and the effect is better than that of a single medicinal material or a simple combination.

The invention discloses a compound enzyme enzymolysis process of a suckling pig liver active peptide as well as a product and application of the suckling pig liver active peptide, and belongs to the technical field of extraction and preparation of functional peptides. The technical problems to be solved are that an adaptive compound enzyme formula is lacked in the existing preparation of the active peptide of the suckling pig liver, the enzymolysis efficiency of a single enzyme or a conventional compound enzyme is low, active peptide components in the suckling pig liver cannot be efficiently released, and the activity is not ideal. In the research and development of bioactive peptides for hepatitis and liver injury, no bioactive peptide from suckling pig liver is efficiently prepared and has a definite liver protection function, and the existing liver protection bioactive peptide has the problems of unstable curative effect and the like. According to the technical scheme, the compound enzyme enzymolysis process is characterized in that compound enzyme is used, and the compound enzyme is composed of neutral protease, papain, trypsin and lipase.

The invention discloses a medicinal and edible biological preparation for dispelling effects of alcohol and protecting liver as well as a preparation method and application of the medicinal and edible biological preparation. The medicinal and edible biological preparation is prepared from the following raw materials in parts by weight: 10 to 15 parts of radix puerariae, 5 to 15 parts of semen hoveniae, 2 to 10 parts of liquorice root, 10 to 15 parts of poria cocos, 6 to 15 parts of honeysuckle flower and 5 to 15 parts of curcumin. After the six extracts are compounded, an excellent hangover alleviating effect is achieved, alcohol metabolism can be accelerated, and the hangover alleviating time can be shortened. Wherein the kudzuvine root, the hovenia dulcis thunb, the poria cocos, the liquorice and the honeysuckle have the effects of protecting liver and benefiting gallbladder, and can inhibit liver injury and promote regeneration of hepatocytes; the turmeric has the effects of dispelling the effects of alcohol, preventing hangover and the like. The composition disclosed by the invention is used as a main active component of the beverage for dispelling effects of alcohol and protecting liver, and has good taste and rich nutritional value. In addition, the influence of the curcumin freeze-dried powder on the activity of ADH and SOD is adjusted under a specific pH value, so that the alcohol effect dispelling effect is optimal.

The present application belongs to the field of nutritional composition and biological medicine technology, and particularly relates to a composition for protecting and preserving liver, a preparation method, application and product thereof. The composition of the present application is composed of extract of Silybum marianum, glucoraphanin and extract of Cynara scolymus. The composition of the present application can intervene the pathological process of liver injury from multiple dimensions such as antioxidation, anti-inflammation, regulation of lipid metabolism and repair of hepatocytes through synergistic effect of the three components, significantly reduces the levels of glutamic-pyruvic transaminase and glutamic-oxalacetic transaminase, reduces the accumulation of liver fat, improves the antioxidant capacity of the body, effectively prevents or improves alcoholic, chemical, non-alcoholic fatty and autoimmune liver injury, delays the progression of liver fibrosis, and comprehensively maintains the structural integrity and functional stability of the liver.

The application discloses application of a triperpenoid compound of Ailanthus-type or a glycoside thereof in preparation of a liver-protecting medicine. The application also performs glycosylation modification on the triperpenoid compound of Ailanthus-type to obtain a liver-protecting active triperpenoid glycoside of Ailanthus-type. The compound has potential application value in preparation of a medicine for preventing or treating liver diseases.

The invention discloses a new application of hyodeoxycholic acid, namely an application of hyodeoxycholic acid in preparation of a medicine for preventing or treating liver injury. A mouse drug-induced liver injury model is established through acetaminophen, ALT, AST, gamma-GT and the like in serum of a mouse given with hyodeoxycholic acid are remarkably reduced, and the liver function is basically recovered; pathological histology shows that the liver form and structure tend to be normal; the levels of inflammatory factors IL-1beta, IL-6 and TNF-alpha in the liver are remarkably reduced, and the inflammatory response of the liver is relieved; meanwhile, the levels of GSH, SOD and the like in liver tissues are improved, MDA accumulation is reduced, and liver oxidative stress is weakened. Therefore, the hyodeoxycholic acid can effectively relieve the APAP-induced drug-induced liver injury, and has great potential in development of liver protection drugs.

The application relates to the field of medicine, in particular to the application of 4-hydroxyphenylacetic acid and irinotecan as cancer chemotherapy drugs. In view of the technical defects that the existing irinotecan chemotherapy hepatoprotective drugs have single action and may interfere with the chemotherapy effect, the application provides the application of 4-hydroxyphenylacetic acid and irinotecan in the preparation of cancer chemotherapy drugs. The application has the following advantages: 1. clear hepatoprotective effect: 4HPAA can significantly alleviate the liver fatty degeneration induced by irinotecan; 2. significant synergistic anti-tumor effect: the tumor inhibition effect of the combination of 4HPAA and irinotecan is significantly better than that of the single-drug group; 3. high safety; and 4. great clinical transformation potential.

The application of mussel polysaccharide in preparation of a medicine for regulating the intestine-liver axis to treat alcoholic liver injury belongs to the technical field of natural products and biological medicine. The method takes mussel polysaccharide as an active ingredient, and divides experimental mice into a normal control group, an alcoholic liver injury model group, a positive control group and mussel polysaccharide low-, medium- and high-dose groups (60, 120 and 180 mg / kg / day), and continuously intervenes for 4 weeks. The results show that the mussel polysaccharide can significantly reduce liver function indexes such as ALT and AST, improve TC, TG, LDL-C, HDL-C related blood lipid disorders, protect the colon mucosal barrier, regulate the intestine-liver axis homeostasis, effectively reduce alcohol-induced liver fatty degeneration, inflammatory infiltration and oxidative stress injury, and the effect shows obvious dose dependence. The mussel polysaccharide is safe, non-toxic, economical in source, simple in intervention method and strong in repeatability, and provides a new way for the development of functional food and liver protection products for preventing and treating alcoholic liver injury.

The application discloses a gentiopicroside compound and a preparation method and application thereof. The gentiopicroside compound has a structure shown in formula 1. A new gentiopicroside compound is separated from a thermal conversion product of gentiopicroside, the preparation method is simple and easy to implement, the compound can protect the liver by inhibiting the activities of glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase, and can be used as a leading compound of liver-protecting drugs.

The invention relates to the technical field of Mongolian medicines, discloses a Mongolian medicine composition for treating a liver-heat-type liver disease, and aims to solve the problems that when an existing Mongolian medicine scheme is used for treating complex diseases with liver parenchyma injury and liver and gall dysfunction, the synergism of liver heat clearing and liver and gall dysfunction is insufficient, and overall intervention is difficult. The Mongolian medicine composition is prepared from twenty-one medicinal materials including bunge corydalis herb, coptis chinensis, fructus gardeniae, bistort rhizome, bear gall powder, fructus choerospondiatis, radix aucklandiae, flos caryophyllata, amomum tsao-ko, myristica fragrans and the like. The traditional Chinese medicine composition is prepared by adopting a staged extraction process, comprehensively plays the effects of protecting the liver, lowering transaminase, benefiting the gallbladder, relieving jaundice and improving the gastrointestinal function, and shows better comprehensive treatment effect and safety on drug-induced, alcoholic and non-alcoholic fatty liver injuries.

The application discloses a rhynoxanthine type diterpene and a preparation method and application thereof; the rhynoxanthine type diterpene is separated from the bark of Cinnamomum cassia, and has at least one of structural formulae as shown in formula (I), formula (II) and formula (III); the rhynoxanthine type diterpene is separated from the bark of Cinnamomum cassia in the Lauraceae Cinnamomum plant; the application uses an alcohol, palmitic acid and other induced liver cell damage models to evaluate hepatoprotective activity, finds that the rhynoxanthine type diterpene can effectively relieve alcohol, palmitic acid and other induced liver cell damage, and indicates that the rhynoxanthine type diterpene has hepatoprotective activity, can be used for preparing hepatoprotective drugs, and has a good research and development prospect.

The application discloses use of Acorus gramineus or an extract thereof in preparation of a medicine for treating and / or preventing diseases caused by liver injury and use in preparation of a medicine for treating and / or preventing diseases and / or conditions related to diseases caused by liver injury. The diseases caused by liver injury can be acute liver injury, chronic liver injury, liver fibrosis, liver cirrhosis, liver cancer and the like. The Acorus gramineus or the extract thereof has a liver protection effect, and proves to have a protective effect on the diseases caused by liver injury through liver function indexes and liver pathological staining, and is expected to become a new therapeutic drug for liver injury diseases.

The invention discloses a liver-protecting kudzu vine root composition and a preparation method and application thereof in the field of medicinal chemistry, and the liver-protecting kudzu vine root composition comprises a kudzu vine root extract, silymarin, a salvia miltiorrhiza extract, vitamins and two traditional Chinese medicine modified raw materials, the two modified raw materials are respectively an ester derivative formed by puerarin and aminobutyric acid and an ester derivative formed by glycyrrhizic acid and aminocaproic acid. The preparation method comprises the following steps: pre-mixing the extracts and the vitamins, adding the two modified raw materials, uniformly mixing, finally adding the pharmaceutic adjuvants, and tabletting and forming. The two modified raw materials are respectively prepared by activating puerarin or glycyrrhizic acid and corresponding aminocarboxylic acid under the action of a specific condensation reagent, condensing and purifying. According to the composition disclosed by the invention, two structurally modified active components are innovatively introduced and have a synergistic effect with a plurality of liver protection raw materials, so that the anti-oxidation, anti-inflammatory and liver protection effects are remarkably enhanced, and the composition can be used for preparing medicines or health-care products for preventing and treating alcoholic liver injury and non-alcoholic fatty liver diseases.

The application discloses application of a combination of lyophilized powder of Haemadipsa integrifascialis and bear gall powder in preparation of a medicine for treating liver injury, and belongs to the technical field of medicines. The application proves through in-vitro HepG2 and HSC-T6 cell experiments and in-vivo CCl4-induced mouse liver injury models that the combination of the lyophilized powder of Haemadipsa integrifascialis and the bear gall powder can significantly improve the survival rate of injured liver cells, inhibit the activation and fibrosis of hepatic stellate cells, reduce the level of inflammatory factors, improve the antioxidant capacity, reduce the pathological injury of liver tissues, and the synergistic effect is significantly better than that of single medicine, and the safety is good. The application provides a new medicine combination and experimental basis for developing a new liver-protecting and anti-liver fibrosis medicine, and has important clinical application and medicine development values.

The present invention relates to the technical field of traditional Chinese medicine and, in particular, to a liver-protecting composition and a method for its preparation. The liver-protecting composition contains, by weight: 10 to 25 parts Lysimachia christinae, 5 to 15 parts Aster tataricus, 5 to 13 parts turmeric, 2 to 8 parts ginseng, 2 to 8 parts Hovenia dulcis Thunb., and a spice additive, wherein the spice additive contains red dates. The present invention relates to a pure traditional Chinese medicinal product that is easy to prepare and convenient to take, has beneficial effects in protecting and nourishing the liver, and also has an effect in alleviating the effects of alcohol.

The invention relates to the technical field of biological pharmacy, in particular to application of a rhizoma polygonati extract in preparation of a medicine for treating liver injury, and the rhizoma polygonati extract is prepared from the following main active ingredients: hexadecanamide, L-valine, 2-pyrrolidine carboxylic acid, 4-oxoproline, manninotriose, succinic acid, choline, D-(-)-ribose, stachyose and L-threonine. The invention proves that the prophylactic administration of the rhizoma polygonati extract can improve the acetaminophen-induced liver injury, so that the rhizoma polygonati extract has important clinical significance on pain patients who need to take acetaminophen for a long time, and can be developed into an effective liver protection auxiliary medicine.

The present application relates to a kind of polypeptide extracted from hemp seed, its amino acid sequence is selected from any one of VADW, VAMP, YQLM, FPQS, FSPSSQQ, YGDQ, WLE, YTGD, VVDNNGRS, PSSQQ, YSYA, WNVN, WIAVK, LNAP, YNLP, FLQ, NYLP, LLY, FNPRG, YTPHW, FDGEL, WDSY, PQNHA, VFTPQ, PQNHA, IEQMPQRS, FNVDSE, PSSQQTR, FQL, LTTVNSY, YNL or YQL.The polypeptide can be applied in the preparation of related drugs such as hypoglycemic, lipid-lowering, liver protection, kidney protection, intestinal flora regulation and the like.

The invention discloses a psidium guajave acid derivative as well as a preparation method and application thereof. The preparation method comprises the following steps: crushing radix sophorae flavescentis root bark, heating and extracting with an ethanol solution, concentrating under reduced pressure to obtain a total extract, dispersing the total extract in water, filtering, eluting filtrate with 732 type cation exchange resin and distilled water to obtain a non-alkaloid part, and extracting with petroleum ether and ethyl acetate to obtain an ethyl acetate extraction part; carrying out silica gel column chromatography, polyamide column chromatography, ODS column chromatography, Sephadex LH-20 column chromatography and preparative HPLC (High Performance Liquid Chromatography) separation and purification on the ethyl acetate extraction part to obtain seven guava acid derivatives, wherein the compounds 1-6 are new compounds. According to the invention, alcohol-induced AML-12 cytotoxicity is adopted to evaluate the liver protection effect of monomeric compounds, and the compounds 1-7 are proved to have obvious inhibition effect on cytotoxicity. A rat alcoholic liver injury model is adopted to evaluate the in-vivo liver protection effect of the psidium guajave acid, it is proved that the psidium guajave acid has an obvious protection effect on alcohol-induced liver injury, and the new application of the psidium guajave acid in preparation of the liver protection medicine is proved.