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Application of dianthrone compound in preparation of anti-inflammatory and liver-protecting medicine

A technology of dianthrone and compound, which is applied in the application field of dianthrone compounds in the preparation of anti-inflammatory and liver-protecting drugs, and can solve the problems of unsatisfactory progress in anti-inflammatory and liver-protecting drugs and limited anti-inflammatory and liver-protecting drugs

Active Publication Date: 2021-11-19
NAT INST FOR FOOD & DRUG CONTROL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004]However, for a long time, the progress in anti-inflammatory and liver protection has not been satisfactory, and the clinical options for anti-inflammatory and liver protection drugs are limited

Method used

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  • Application of dianthrone compound in preparation of anti-inflammatory and liver-protecting medicine
  • Application of dianthrone compound in preparation of anti-inflammatory and liver-protecting medicine
  • Application of dianthrone compound in preparation of anti-inflammatory and liver-protecting medicine

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0062] Experimental Example 1 Test of HSW-W-25 / 26's activity on phytohemagglutinin (ConA)-induced immune liver injury in mice

[0063] experimental method:

[0064] SPF grade male ICR mice (20-22g), were randomly divided into blank control group, 20% plant lectin (ConA) model group, positive control drug bicyclol 200mg / kg group, HSW-W-25 / 260.1 after adapting to the environment mg / kg group, HSW-W-25 / 261mg / kg group, 7-8 rats in each group. Each dose group of the test substance was administered once in the afternoon of the day before modeling, and in the morning and afternoon of the same day, for a total of 3 administrations. The animals in the blank control group and the model group were given the same amount of 0.5% CMC-Na solution . 2 hours after the last administration, mice in each group were injected with 20% ConA 10ml / kg once in the tail vein except the blank control group. After the mice were fasted for 16 hours, the mice were sacrificed, blood was collected to prepare...

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Abstract

Particularly relates to application of dianthrone compounds in preparation of anti-inflammatory and liver-protecting medicines, and belongs to the technical field of biological medicines. The invention provides an application of a dianthrone compound in preparation of an anti-inflammatory and liver-protecting medicines. The dianthrone compound comprises Trans-emodin dianthrone and / or Cis-emodin dianthrone. The invention provides application of the dianthrone compound in preparation of anti-inflammatory and liver-protecting medicines, and results of the embodiment show that the dianthrone compound has the following significant pharmacological activities: significantly improving immune liver injury of mice, improving pathological injury of liver tissues, and reducing serum liver injury biomarkers.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of dianthrone compounds in the preparation of anti-inflammatory and liver-protecting drugs. Background technique [0002] In recent years, the incidence of drug-induced liver disease, alcoholic liver disease, metabolic-related fatty liver disease, and autoimmune liver disease has also been increasing year by year. It is well known that liver disease is a progressive disease, and various evidences have suggested that liver inflammation occurs in almost all causes of liver disease, and often throughout the course of liver disease. [0003] Anti-inflammatory and liver-protective therapy is an important part of the comprehensive treatment of liver inflammation. For liver inflammation, regardless of whether there is an effective etiological therapy, anti-inflammatory and liver-protective therapy should be considered; Patients should consider anti-inflammatory and ...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61P1/16A61P29/00
CPCA61K31/122A61P1/16A61P29/00
Inventor 马双成孙华魏锋杨建波欧阳婷汪褀陈子涵王莹宋云飞陈智伟高慧宇王雪婷
Owner NAT INST FOR FOOD & DRUG CONTROL
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