Application of steroid saponin compound in medicinal materials of trillium or paris polyphylla to preparation of liver protection medicine

A technology of steroidal saponins and tertiary saponins, which are applied in the directions of drug combination, digestive system, pharmaceutical formula, etc.
CN106902129AActive Publication Date: 2017-06-30张忠立
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
张忠立
Publication Date
2017-06-30

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Abstract

The invention relates to application of a steroid saponin compound in medicinal materials of trillium or paris polyphylla to preparation of a liver protection medicine. The prepared steroid saponin compound in the medicinal materials of trillium or paris polyphylla is one or more of pennogenin-3-0-alpha-L-rhamnopy ranosyl group(1 to 2)-beta-D-glucoside (namely polyphyllin VI), pennogenin-3-0-alpha-L-rhamnopy ranosyl group(1 to 4)-[alpha-L-rhamnopy ranosyl group(1 to 2)]-beta-D-glucoside and pennogenin-3-0-alpha-L-rhamnopy ranosyl group(1 to 4)-alpha-L-rhamnopy ranosyl group(1 to 4)-[alpha-L-rhamnopy ranosyl group(1 to 2)]-beta-D-glucoside (namely polyphyllin VII), and as the common structure units like the pennogenin-3-0-alpha-L-rhamnopy ranosyl group(1 to 2)-beta-D-glucoside (namely polyphyllin VI) are owned, the steroid saponin compound in the medicinal materials of trillium or paris polyphylla has remarkable effects of treating any hepatitis or liver injury in alcoholic hepatitis or liver injury, nonalcoholic hepatitis or liver injury, alcoholic fatty liver, non-alcoholic fatty liver, hepatic fibrosis or liver cirrhosis.
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Description

Technical field

[0001] The invention relates to the application of steroidal saponins in medicinal materials of the genus Trillium or the genus Ceratoides in the preparation of liver-protecting or liver-protecting drugs, and belongs to the technical field of traditional Chinese medicine preparation. Background technique

[0002] Chemical studies have shown that the trillium and the genus of medicinal materials mainly contain steroidal saponins, sesquiterpenes, phenylpropanoid glycosides and phenolic acids, among which the trillium and the genus of medicinal materials The types of steroidal saponins are basically the same, mainly partial sapogenin-3-O-α-L-rhamnanopyranosyl (1 → 2)-β-D-glucoside (i.e. saponins VI), Pynosapogenin-3-O-α-L-rhamnopyranosyl (1→4)-[α-L-rhamnopyranosyl(1→2)]-β-D-glucoside and Pynosapogenin-3-O-α-L-rhamnanoyl(1→4)-α-L-rhamnanoyl(1→4)-[α-L-rhamnose Glycosyl (1→2)]-β-D-glucoside (i.e. saponins VII), the above three steroidal saponins are not only the index...

Claims

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