Application of steroid saponin compound in medicinal materials of trillium or paris polyphylla to preparation of liver protection medicine

Abstract

The invention relates to application of a steroid saponin compound in medicinal materials of trillium or paris polyphylla to preparation of a liver protection medicine. The prepared steroid saponin compound in the medicinal materials of trillium or paris polyphylla is one or more of pennogenin-3-0-alpha-L-rhamnopy ranosyl group(1 to 2)-beta-D-glucoside (namely polyphyllin VI), pennogenin-3-0-alpha-L-rhamnopy ranosyl group(1 to 4)-[alpha-L-rhamnopy ranosyl group(1 to 2)]-beta-D-glucoside and pennogenin-3-0-alpha-L-rhamnopy ranosyl group(1 to 4)-alpha-L-rhamnopy ranosyl group(1 to 4)-[alpha-L-rhamnopy ranosyl group(1 to 2)]-beta-D-glucoside (namely polyphyllin VII), and as the common structure units like the pennogenin-3-0-alpha-L-rhamnopy ranosyl group(1 to 2)-beta-D-glucoside (namely polyphyllin VI) are owned, the steroid saponin compound in the medicinal materials of trillium or paris polyphylla has remarkable effects of treating any hepatitis or liver injury in alcoholic hepatitis or liver injury, nonalcoholic hepatitis or liver injury, alcoholic fatty liver, non-alcoholic fatty liver, hepatic fibrosis or liver cirrhosis.

Description

Technical field [0001] The invention relates to the application of steroidal saponins in medicinal materials of the genus Trillium or the genus Ceratoides in the preparation of liver-protecting or liver-protecting drugs, and belongs to the technical field of traditional Chinese medicine preparation. Background technique [0002] Chemical studies have shown that the trillium and the genus of medicinal materials mainly contain steroidal saponins, sesquiterpenes, phenylpropanoid glycosides and phenolic acids, among which the trillium and the genus of medicinal materials The types of steroidal saponins are basically the same, mainly partial sapogenin-3-O-α-L-rhamnanopyranosyl (1 → 2)-β-D-glucoside (i.e. saponins VI), Pynosapogenin-3-O-α-L-rhamnopyranosyl (1→4)-[α-L-rhamnopyranosyl(1→2)]-β-D-glucoside and Pynosapogenin-3-O-α-L-rhamnanoyl(1→4)-α-L-rhamnanoyl(1→4)-[α-L-rhamnose Glycosyl (1→2)]-β-D-glucoside (i.e. saponins VII), the above three steroidal saponins are not only the index...

AI Technical Summary

Problems solved by technology

The present inventors induced the liver injury model by intraperitoneally injecting 40% carbon tetrachloride olive oil solution while feeding and drinking 13-degree liquor, and the research confirmed that the steroidal saponins in the medicinal materials of the genus Trillium or Patricia genus pinanogenin-3 ‐O‐α‐L‐rhamnopyranosyl (1→2)‐β‐D‐glucoside (ie saponin VI), pinanogenin‐3‐O‐α‐L‐rhamnopyran Glycosyl(1→4)‐[α‐L‐rhamnopyranosyl(1→2)]‐β‐D‐glucoside and pinanogenin‐3‐O‐α‐L‐rhamnopyranosyl Glycosyl (1→4)‐α‐L‐rhamnopyranosyl (1→4)‐[α‐L‐rhamnopyranosyl (1→2)]‐β‐D‐glucoside (ie Saponin VII) monomeric compounds of Pachyphyllum saponins have hepatoprotective or hepatoprotective pharmacological effects. The above studies have not been reported yet. Through experimental research on whole animals, we first found that the above three steroidal saponins in Trillium genus or Pachyphyllum genus medicinal materials These compounds have anti-inflammatory and anti-oxidation properties to protect acute and chronic liver injuries, and their active ingredients have significant therapeutic effects, providing a basis for the development of new liver-protecting drugs and guiding clinical medication

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