A new rotenone-type flavonoid compound and its preparation method and application

A technology of flavonoids and rotenone, which is applied in the field of medicine, can solve the problems of less research on chemical components and unseparated chemical components, and achieve the effects of simple preparation methods, high yields, and abundant raw material resources

Inactive Publication Date: 2021-04-23
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to modern literature reports, Arrowhead mainly contains flavonoids, terpenoids, and volatile oils. However, compared with the research on the chemical constituents of medicinal plants in other genera of Asteraceae, scholars at home and abroad have studied the chemical constituents of Arrowhead. Relatively few, mainly focused on partial research on crude extracts such as flavonoids, terpenoids, and volatile oils, without systematic separation of chemical components

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A new rotenone-type flavonoid compound and its preparation method and application
  • A new rotenone-type flavonoid compound and its preparation method and application
  • A new rotenone-type flavonoid compound and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A new rotenone type flavonoid compound, the molecular formula of the new rotenone type flavonoid compound is C 26 h 24 o 6 , the structural formula is as follows:

[0029] ,

[0030] The chemical name is: 2-(1'-isopropenyl)-7,8-dimethoxy-14,14-dimethyl-benzopyran-10-one.

[0031] The preparation method of above-mentioned new rotenone type flavonoids, comprises the following steps:

[0032] (1) Take the dried Arrowhead and crush it through a 20-40 mesh sieve, then heat and reflux with an ethanol solution with a volume fraction of 50-70% to extract 3-5 times, each extraction time is 4-6 hours, filter, Combine the filtrates, and concentrate the filtrates under reduced pressure at 40-60°C and evaporate to dryness until there is no alcohol smell, so as to obtain the total thick paste of arrowroot;

[0033] (2) Suspend the Arrowhead thick paste prepared in step (1) in water, let it stand, remove the water-insoluble matter to obtain a filtrate, add cyclohexane to the f...

Embodiment 2

[0040] A kind of preparation method of new rotenone-type flavonoids (flow process is as follows figure 1 shown), including the following steps:

[0041] (1) Take 12.0Kg of dried Arrowhead and crush it through a 30-mesh sieve, then heat and reflux extraction with 60% ethanol solution for 4 times, each extraction time is 5 hours, filter, combine the filtrate, and extract the filtrate Concentrate under reduced pressure and evaporate to dryness at 50°C until there is no alcohol smell, and 960.5g of the total thick paste of Arrowhead is obtained;

[0042](2) Suspend the total thick paste of Arrowhead Chrysanthemum prepared in step (1) in water, let it stand, remove the water-insoluble matter to obtain a filtrate, add cyclohexane to the filtrate and extract continuously for 3 times, and combine the extracts to obtain 46.8g cyclohexane extract and cyclohexane extract filtrate, add ethyl acetate to the cyclohexane extract filtrate and extract continuously for 3 times, combine the ex...

Embodiment 3

[0049] A preparation method of new rotenone-type flavonoids, comprising the following steps:

[0050] (1) Take 8.0Kg of dried Arrowhead and crush it through a 20-mesh sieve, then heat and reflux extraction with 70% ethanol solution for 3 times, each extraction time is 4.5 hours, filter, combine the filtrate, and extract the filtrate Concentrate under reduced pressure and evaporate to dryness at 40°C until there is no alcohol smell, and 646.9 g of the total thick paste of Arrowhead is obtained;

[0051] (2) Suspend the total thick paste of Arrowhead Chrysanthemum prepared in step (1) in water, let it stand, remove the water-insoluble matter to obtain a filtrate, add cyclohexane to the filtrate and extract continuously for 3 times, and combine the extracts to obtain 30.9g cyclohexane extract and cyclohexane extract filtrate, add ethyl acetate to the cyclohexane extract filtrate and extract continuously for 3 times, combine the extracts to obtain 57.9g ethyl acetate extract and c...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to view more

Abstract

The invention relates to a new rotenone-type flavonoid compound and its preparation method and application. The structural formula of the new rotenone-type flavonoid compound is as follows:. The new rotenone-type flavonoids have a novel structure, simple extraction and separation methods, and significant hepatoprotective activity, providing an important experimental basis and theoretical basis for the discovery of new hepatoprotective drugs from Arrowflower.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a new rotenone-type flavonoid compound isolated from Tibetan medicine Arrowhead Chrysanthemum and its preparation method and application. Background technique [0002] Currently, liver disease has become one of the major threats to human health worldwide. The liver is the most important site of body metabolism and plays an important role in maintaining the life activities of the body. Liver injury refers to a type of liver cell apoptosis, necrosis or autoimmunity caused by various factors (such as genetic variation, virus infection, cholestasis, steatosis, drug abuse, alcohol intake, chemical injury and autoimmunity, etc.). Liver disease characterized by phagocytosis. Further development of liver damage can lead to liver fibrosis, and further deterioration into serious diseases such as liver cirrhosis and liver cancer. At present, there is no specific drug in mod...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/14A61P1/16
CPCA61P1/16C07D493/14
Inventor 魏荣锐马勤阁钟国跃杨明
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap