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A standardized extract of jujube leaves and its preparation and application

An extract and technology of jujube, applied in the field of jujube branch and leaf extract and its extraction, can solve the problems such as the extraction method and use of the jujube branch and leaf extract that have not yet been seen, and achieve the effect of good hepatoprotective activity

Inactive Publication Date: 2019-11-26
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Through literature search of the prior art, it is found that the research on jujube fruit jujube is very in-depth, but there are no reports related to jujube branch and leaf extract and its extraction method and use.

Method used

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  • A standardized extract of jujube leaves and its preparation and application
  • A standardized extract of jujube leaves and its preparation and application
  • A standardized extract of jujube leaves and its preparation and application

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Embodiment Construction

[0030] In order to make the objects and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0031] Such as figure 1 Shown, the embodiment of the present invention provides a kind of preparation method of jujube leaf standardized extract, comprises the following steps:

[0032] Step 1, get 5kg of jujube leaves, and pulverize;

[0033] Step 2, the pulverized jujube leaves are extracted twice with absolute ethanol by percolation, each time for 24 hours, filtered, and the two ethanol extracts are combined to obtain the jujube leaves-EtOH extract; the filter residue is extracted twice with water, each time for 24 hours , after merging, red jujube leaf-Water extract is obtained;

[0034] Step 3. The above two extracts are combined and con...

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Abstract

The invention discloses a standardized extract of red jujube leaves and its preparation method and application. The extract contains the following components: oleic acid-3-O-trans-p-coumaroyl ester 134.96 μg / g; Acid-3-O-cis-p-coumaroyl ester 5.27μg / g; benzoic acid 6.75μg / g; 2,4-dihydroxyphenol 6.47μg / g; p-hydroxybenzoic acid 77.14μg / g; o-hydroxybenzoic acid Benzoic acid 2.24μg / g; rutin 25.13μg / g; p-hydroxybenzaldehyde 10.25μg / g; maslinic acid-3-O-trans-p-coumaroyl ester 3.84μg / g; p-hydroxycis-cinnamic acid 1.71μg / g; p-hydroxy trans-cinnamic acid 9.38μg / g; 3,4-dihydroxybenzoic acid: 1.85μg / g. Activity test results show that the red date leaf extract has hepatoprotective activity and can be used to make hepatoprotective drugs.

Description

technical field [0001] The invention relates to an extract in the technical field of medicine, its extraction method and application, in particular to an extract of jujube branches and leaves, its extraction method, quantitative analysis method and application. Background technique [0002] Jujube is a deciduous shrub or small tree plant of the genus Jujube in the family Rhamnaceae. Up to more than ten meters, the crown is oval, the bark is taupe, and there are strip cracks. Branches include long branches, short branches and budless branchlets, long branches reddish brown, smooth, zigzag curved, with 2 stipules; short branches alternate on long branches that are more than biennial; deciduous branchlets are slender, green , no buds, clustered on short branches, fall with leaves after autumn. The leaves are oval or ovate-elliptic, with short and pointed front ends, and three main veins emerge from the base. Both sides of the leaves are glabrous, shiny, and have fine teeth on...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/725A61P1/16A61K127/00
CPCA61K36/725A61K2236/33A61K2236/331A61K2236/39
Inventor 白乃生白璐吴勇刘庆超张丽郭森崔雪琴江咪
Owner NORTHWEST UNIV
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