Application of active ingredients of Trillium medicinal materials in preparation of liver-protecting or liver-protecting drugs

Abstract

The invention relates to the application of steroidal saponin compounds in Trillium genus or Patricia genus medicinal materials in the preparation of liver-protecting or liver-protecting medicines. The steroidal saponins in the prepared Trillium genus or Patricia genus medicinal materials themselves are pinanogenin‑3‑ O ‑α‑ L ‑Rhamnopyranosyl (1→2)‑β‑ D ‑Glucoside (i.e. papaya saponin VI), pinanogenin‑3‑ O ‑α‑ L ‑Rhamnopyranosyl (1→4)‑[α‑ L ‑rhamnopyranosyl (1→2)]‑β‑ D ‑Glucosides and Pinogenin‑3‑ O ‑α‑ L ‑Rhamnopyranosyl (1→4)‑α‑ L ‑Rhamnopyranosyl (1→4)‑[α‑ L ‑rhamnopyranosyl (1→2)]‑β‑ D One or more of ‑glucosides (i.e. papaya saponin VII), due to the common innosapogenin ‑3‑ O ‑α‑ L ‑Rhamnopyranosyl (1→2)‑β‑ D ‑glucoside (i.e. saponin Ⅵ) and other structural units, and in the human body have the ability to treat alcoholic hepatitis or liver damage, non-alcoholic hepatitis or liver damage, alcoholic fatty liver, non-alcoholic fatty liver, liver fibrosis or Significant efficacy of either hepatitis or liver damage in cirrhosis.

Description

technical field [0001] The invention relates to the application of steroidal saponin compounds in Chinese Trillium genus or Patricia genus medicinal materials in the preparation of liver-protecting or liver-protecting medicines, and belongs to the technical field of traditional Chinese medicine preparation. Background technique [0002] Chemical studies have shown that Chinese Trillium and Chonglou mainly contain steroidal saponins, sesquiterpenoids, phenylpropanoid glycosides and phenolic acids, among which Chinese Trillium and Chonglou The composition types of steroidal saponins in medicinal materials are basically the same, mainly pinanogenin-3-O-α-L-rhamnopyranosyl (1→2)-β-D-glucoside (ie, saponin Ⅵ ), pinanogenin-3-O-α-L-rhamnopyranosyl(1→4)-[α-L-rhamnopyranosyl(1→2)]-β-D-glucose Glycoside and pinanogenin-3-O-α-L-rhamnopyranosyl(1→4)-α-L-rhamnopyranosyl(1→4)-[α-L-rhamnopyranosyl Rhamnosyl (1→2)]-β-D-glucoside, the above three steroidal saponins are not only the index ...

AI Technical Summary

Problems solved by technology

The present inventor through the intraperitoneal injection of 40% carbon tetrachloride olive oil solution while feeding and drinking 13 degrees of liquor-induced liver injury model, the study confirmed that the steroidal saponins in the Chinese Trillium genus or Patricia genus pinanogenin- 3-O-α-L-rhamnopyranosyl (1→2)-β-D-glucoside (ie saponin Ⅵ), pinanogenin-3-O-α-L-rat Lisosyl(1→4)-[α-L-rhamnopyranosyl(1→2)]-β-D-glucoside and pinosenogenin-3-O-α-L-rhamnopyranosyl Lisyl(1→4)-α-L-rhamnopyranosyl(1→4)-[α-L-rhamnopyranosyl(1→2)]-β-D-glucoside mono The above-mentioned researches have not been reported yet. Through the experimental study of whole animals, we first found that the above three steroidal saponins in the medicinal materials of the genus Trillium or Pachyphysis in China have anti-inflammatory properties. , anti-oxidation and play a protective role against acute and chronic liver damage, and its active ingredients have a significant therapeutic effect, providing a basis for the development of new liver-protecting drugs and guiding clinical medication

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