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Application of Geranium wilfordii Maxim. polysaccharide in preparation of liver-protecting drugs

A technology of geranium and polysaccharide, applied in the biological field, can solve problems such as obvious side effects and troubles

Active Publication Date: 2020-06-19
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current drugs for autoimmune hepatitis are some immunosuppressants such as glucocorticoids, and their side effects have always been one of the problems in clinical treatment.

Method used

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  • Application of Geranium wilfordii Maxim. polysaccharide in preparation of liver-protecting drugs

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Effect test

preparation example Construction

[0022] The preparation method of the geranium polysaccharide is as follows: crush the geranium medicinal material, reflux and degrease it with methanol, extract it with 80°C water, and precipitate it with 80% ethanol. Deprecipitate to obtain refined geranium polysaccharide.

[0023] Geranium polysaccharide achieves hepatoprotective effect by reducing serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) values

[0024] The dose of geranium polysaccharide is 2-3 times a day, 0.4-1.8g each time.

[0025] The dose of geranium polysaccharide is 3 times a day, 1g each time.

[0026] The geranium polysaccharide is added with pharmaceutically acceptable auxiliary materials to prepare tablets, hard capsules, soft capsules, powders, pills and granules.

[0027] The geranium polysaccharide is used as an active ingredient or a medicinal carrier.

Embodiment 1

[0029] Preparation of crude polysaccharides from Geranium geranium: Grind the medicinal material of Geranium geranium, and degrease with methanol at 60° C. for 3 times. The degreased geranium medicinal material was boiled and extracted in hot water at 80° C. for 3 hours each time, and extracted twice in total. The extracts were combined and concentrated under reduced pressure. Precipitate the concentrated extract with 80% ethanol, centrifuge, and discard the supernatant to obtain the crude polysaccharide of geranium.

Embodiment 2

[0031] Refining of geranium polysaccharides: redissolve the obtained geranium polysaccharides with distilled water, remove protein by sevege method, centrifuge, discard the precipitate, a total of 5 times, until no more precipitate after centrifugation. Finally, the polysaccharide after removing the protein was concentrated under reduced pressure, freeze-dried, and the content of the polysaccharide was detected by the sulfuric acid-phenol method, and finally the refined geranium polysaccharide was obtained.

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Abstract

The invention belongs to the technical field of biology, and specifically relates to preparation of Geranium wilfordii Maxim. polysaccharide and application of the Geranium wilfordii Maxim. polysaccharide in development of liver-protecting drugs. An immunological liver injury model induced by canavaline A is adopted, and the liver-protecting activity of the immunological liver injury model is investigated. An experiment result shows that the Geranium wilfordii Maxim. polysaccharide is capable of remarkably decreasing liver function indexes of a mouse with liver injury, can be used for researching and developing the liver-protecting drugs, particularly drugs for treating immunological liver injury. The application has an important significance to further development and utilization of Geranium wilfordii Maxim..

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a preparation method of geranium polysaccharide and its application in the development of liver-protecting drugs. Background technique [0002] Autoimmune hepatitis is a chronic hepatitis mediated by an autoimmune reaction. Its clinical features are varying degrees of serum transaminase AST, ALT elevation, hypergammaglobulinemia, positive autoantibodies, and histological features are infiltration of lymphocytes and plasma cells. Mainly interface hepatitis, severe cases can develop into cirrhosis. Currently, some immunosuppressants, such as glucocorticoids, are used to treat autoimmune hepatitis, and their side effects have always been one of the problems in clinical treatment. Combined with clinical practical problems, it is imminent to find hepatoprotective drugs with low toxicity and significant effect. [0003] Polysaccharides are widely found in plants, algae, fungi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K36/185A61P1/16
CPCA61K31/715A61K36/185A61P1/16A61K2236/331A61K2236/53
Inventor 刘录陈忠艺马晓霞周志宏张鹏祁燕倪广惠
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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