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Application of cajanin in preparation of medicine for preventing and/or treating medicine-induced liver injury

A technology for drug-induced liver injury and drug treatment, applied in the field of medicine, can solve problems such as liver injury, and achieve good therapeutic effect and significant application value.

Inactive Publication Date: 2021-11-02
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, inappropriate administration of APAP can lead to severe liver damage and is the most common cause of acute liver failure in many countries

Method used

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  • Application of cajanin in preparation of medicine for preventing and/or treating medicine-induced liver injury
  • Application of cajanin in preparation of medicine for preventing and/or treating medicine-induced liver injury
  • Application of cajanin in preparation of medicine for preventing and/or treating medicine-induced liver injury

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0016] Experimental Example 1. Therapeutic Effects of Gastralin on Drug-Induced Liver Injury Caused by APAP

[0017] 1. Experimental materials

[0018] Experimental animals: C57BL / 6N male mice, weighing 20-22g, 24 were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., production license: SCXK (Beijing) 2016-0006. The conventional diet of mice was provided by Weitong Lihua Experimental Animal Technology Co., Ltd. Mice were raised in an SPF-grade environment (Experimental Animal Room of the Institute of Medicinal Plants, Chinese Academy of Medical Sciences [SYXK (Beijing) 2018-0020]), maintaining a 12h light: 12h dark circadian rhythm, temperature 23-25°C, humidity 45%- 65%, each group is 6 / cage, free to drink water and eat. The experiment was reviewed and approved by the Experimental Animal Management and Animal Welfare Committee of the Institute of Medicinal Plants, Chinese Academy of Medical Sciences (approval number: SLXD-20191219001).

[0019...

experiment example 2

[0036] Experimental Example 2. Therapeutic Effect of Intraperitoneal Injection of Phalin on Drug-Induced Liver Injury Caused by APAP

[0037] 1. Experimental materials

[0038] Experimental animals: The experiment was reviewed and approved by the Experimental Animal Management and Animal Welfare Committee of the Institute of Medicinal Plants, Chinese Academy of Medical Sciences (approval number: SLXD-20200103001). Others are the same as experimental example 1.

[0039] Drugs and reagents: the same as Experimental Example 1.

[0040] 2. Experimental method

[0041]Grouping and administration: Mice were divided into blank control group, APAP liver injury model group, low-dose phyloganin treatment group (50 mg / kg) and high-dose treatment group (75 mg / kg), and acclimated to the environment in the animal room for 7 days. Mice were fasted without food and water for 16 hours before the formal experiment. The blank control group was injected with normal saline, the APAP liver inju...

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to novel application of cajanin in prevention and treatment of drug-induced liver injury. Animal experiments firstly prove and disclose that cajanin can effectively treat drug-induced liver injury caused by acetaminophen. The invention further discloses application of the cajanin to preparation of the medicine for preventing and / or treating the medicine-induced liver injury. The invention provides a scientific basis for developing the liver-protecting medicine taking the cajanin as the active ingredient, and has important application value.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to cajaninstilbene acid (CSA) (chemical name: 2-carboxy-3-hydroxyl-4-prenyl-5-methoxystilbene, 2-carboxyl-3- hydroxy-4-prenyl-5-methoxystilben) in the preparation of drugs for preventing and / or treating drug-induced liver injury. Background technique [0002] Drug-induced liver injury (DILI) refers to the liver injury induced by various prescription or over-the-counter chemical drugs, biological agents, traditional Chinese medicines, natural medicines, health products, dietary supplements and their metabolites, and even excipients. of liver damage. Acute DIL1 currently reported in my country accounts for about 20% of hospitalizations for acute liver injury, and the incidence is gradually increasing. As one of the most common and serious adverse drug reactions, DILI can cause acute liver failure or even death in severe cases. Therefore, DILI has become a public health problem tha...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61P1/16A61K36/48A61K127/00
CPCA61K31/192A61P1/16A61K36/48
Inventor 闫明珠常琪靳苏维王智夏天吉刘永广
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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