315 results about "Treatment medication" patented technology

The invention relates to an application of Danjie emodin in preparation of drugs for preventing or treating drug-induced liver injury. The liver injury is drug-induced liver injury induced by acetaminophen. According to the invention, the effective component Danleaf emodin in the traditional Chinese medicine rhubarb is used for preventing and treating drug-induced liver injury induced by acetamido, and the traditional Chinese medicine composition has the characteristics of safety, reliability and small toxic and side effects. Starting from the whole, multi-target intervention is performed on drug-induced liver injury induced by acetaminophen, the levels of glutamic-pyruvic transaminase, glutamic oxalacetic transaminase and malondialdehyde in plasma are remarkably reduced, the obvious anti-inflammatory and liver cell apoptosis inhibiting effects are achieved, the good clinical application prospect is achieved, and a new way is provided for prevention and treatment of liver injury.

The invention aims to provide a preparation method and application of an inhalation drug-loading ultrasonic driving nano motor, and can effectively solve the problems of preparation of the inhalation drug-loading ultrasonic driving nano motor and application of the inhalation drug-loading ultrasonic driving nano motor in preparation of drugs for treating IPF. Comprising the following steps: firstly preparing PLGA-PFD nanoparticles, then preparing PDA-PLGA-PFD nanoparticles, and finally preparing BNN6 / PDA-PLGA-PFD, namely the asymmetric nano motor BPPP with the ultrasonic responsiveness. The product disclosed by the invention is scientific and advanced in preparation method, good in product performance, high in atomization administration and IPF lung pathological barrier penetrating capability, high in medicine utilization rate, good in curative effect, simple and convenient to operate, wide in application prospect and huge in economic and social benefits.

The invention discloses an application of core proteoglycan or a coding gene thereof as a target spot in preparation of psoriasis treatment drugs, and a series of experiments prove that DCN can effectively protect mouse psoriasis-like dermatitis induced by imiquimod, improve skin scale, erythema, thickening and epidermal abnormal differentiation, enhance the barrier function of skin, improve the curative effect of psoriasis, and improve the curative effect of psoriasis. A large amount of infiltration of inflammatory cells is reduced, and a certain anti-inflammatory effect is achieved. Experimental research shows that the DCN has an obvious drug effect on a psoriasis model, is safe and efficient, has no side effect, is simple in production process and has the potential of realizing medical transformation. And the potential application value of the DCN on other various skin inflammatory diseases can be expanded.

The present invention provides a novel therapeutic drug for treating a Prom1-associated retinal disease. Specifically, the present invention provides an optimized Prom1 gene expression cassette, an rAAV viral vector, and a gene therapy drug. The drug of the present invention can specifically express the PROM1 protein in the retinal photoreceptor layer, and is suitable for the clinical treatment of a retinal disease associated with Prom1 gene mutation.

The invention relates to the field of biomedicine, particularly provides a copper-based nano-enzyme as well as a preparation method and application thereof, and aims to solve the problems that in the prior art, clinical treatment on primary sclerosing cholangitis (PSC) is difficult in diagnosis and lacks of effective treatment drugs. The copper-based nano-enzyme comprises a nano-enzyme carrier and a copper-based nano-enzyme, wherein the nano-enzyme carrier is a two-dimensional nanosheet formed by copper ions, gallic acid and ursodesoxycholic acid through coordinate bonds; the probe molecule is a cyanine dye molecule connected to the surface of the nano-enzyme carrier through a covalent bond; wherein the fluorescence intensity of the copper-based nano enzyme is enhanced after the action of the alkaline phosphatase. The three functions of alkaline phosphatase responsive diagnosis, nano-enzyme catalytic treatment and ursodesoxycholic acid hepatic targeting are innovatively and synergistically integrated into one nano platform, the treatment function can be executed while specific imaging diagnosis is performed on diseases, and a new strategy is provided for diagnosis and treatment of diseases such as PSC.

The invention relates to the fields of biology, medicine and clinic. In particular to application of PAICS as a target spot in developing or screening reagents for preventing and / or treating orthopoxvirus infection, and application of inhibiting a synthetic pathway of purine nucleotide and / or inhibiting a metabolic pathway of folic acid in preparing reagents for treating and / or preventing orthopoxvirus infection diseases. In order to restrain the infection of orthopoxvirus, the inventor team uses a CRISPR / Cas9 technology to carry out generic genome screening on host cells infected by orthopoxvirus, determines a host-dependent gene PAICS gene in the orthopoxvirus infection process, and verifies and clarifies the virus-dependent mechanism of the gene; in order to deal with the global continuous orthopoxvirus infection problem, the invention plays an important role in the development and screening of future related prevention or treatment drugs, and also expands the new clinical application of existing drugs including methotrexate, mercaptopurine, mizoribine and the like.

The invention discloses nano-particles with antibacterial and osteogenesis promoting effects as well as a preparation method and application of the nano-particles, and belongs to the technical field of antibacterial nano-materials. On one hand, the invention provides the nano-particles with antibacterial and osteogenesis promoting effects and the preparation method thereof, and on the other hand, the invention provides the application of the nano-particles. The nanoparticles obtained by the method disclosed by the invention have good stability under physiological conditions (PH = 7.4); polyphenol, metal ions and AMP (adenosine monophosphate) can be slowly released in an inflammatory (weakly acidic) environment, and the functions including but not limited to bacterium capturing, bacterium killing, inflammation and oxidation resisting, osteogenesis promoting and the like are realized; the nano-particles can be used for preparing a bone infection treatment drug, and the bone infection treatment drug has a broad-spectrum antibacterial effect and cannot cause antibiotic drug resistance; the treatment medicine can efficiently prevent and treat bone infection and improve bone repair efficiency.

The invention discloses application of GSK2606414 in preparation of a medicine for inhibiting duck tembusu virus infection, and belongs to the technical field of veterinary biological products. The research finds that the GSK2606414 can effectively inhibit the replication of the duck tembusu virus for the first time, provides a new therapeutic drug for the prevention and treatment of the duck tembusu virus, and is of great significance to the actual production of the poultry breeding industry.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to application of a traditional Chinese medicine composition in preparation of anti-hepatoma medicines. The traditional Chinese medicine composition comprises red ginseng, ox horn tip, musk, borneol, safflower, bezoar, radix aconiti lateralis praeparata slice, venenum bufonis, pseudo-ginseng, benzoin and pearl. Experimental results show that the traditional Chinese medicine composition can induce apoptosis and necrosis of liver cancer cells and inhibit proliferation of the liver cancer cells; and liver cancer cells are retarded to be in a G1 cell cycle. Therefore, the invention provides a new therapeutic drug for clinical treatment of liver cancer, and the raw materials are natural medicinal materials, have wide sources and have good application prospects.

The invention discloses a preparation method of a cochlear organ chip integrated with a blood labyrinth barrier, and belongs to the field of biomedical engineering. The preparation method of the simulated blood labyrinth barrier comprises the following steps: constructing an endothelial cell culture cavity and a pericyte culture cavity, and separating the endothelial cell culture cavity and the pericyte culture cavity through a simulated basement membrane; and respectively inoculating percutaneous cells and endothelial cells into a percutaneous cell culture cavity and an endothelial cell culture cavity, and culturing to obtain the simulated blood lost barrier. The chip can effectively simulate the structure and the function of the BLB, and the barrier integrity of the BLB is evaluated through TEER (trans-epithelial electrical resistance) measurement and an apparent permeability coefficient. The invention also relates to application of the chip in NIHL drug screening, in particular to drug evaluation for oxidative stress induced inner ear organ injury. Through the platform, the protection effect of the candidate drugs on the TBHP-induced oxidative stress injury of the inner ear organs can be evaluated, and a new tool and thought are provided for developing novel NIHL treatment drugs.

The invention provides a novel therapeutic drug for treating Prom1 related retinal diseases. Specifically, the invention provides an optimized Prom1 gene expression cassette, an rAAV virus vector and a gene therapy drug. The medicine provided by the invention can specifically express the PROM1 protein in a retina photoreceptor layer, and is suitable for clinical application to treatment of Prom1 gene mutation related retinal diseases.

A portable emergency response kit designed for rapid intervention in opioid overdose or cardiac arrest scenarios comprises a durable case with compartments for specific medical devices, such as opioid overdose treatment medication or an Automated External Defibrillator (AED). The case features a breakable closed circuit that is, upon opening, triggered to send a signal to notify emergency medical services (EMS) or predefined contacts of the kit's location.The system utilizes GPS module and may include dual-mode communication capabilities for reliable alert transmission in various environments. Additional features may include a transparent case material for visual confirmation of contents, tamper-evident seals, QR codes linked to instructional content, and a battery power source. The kit is designed to be user-friendly, incorporating ergonomic elements and optional accessories for enhanced portability and storage, ensuring rapid and effective response in critical situations.

The invention discloses a multi-stage leaching purification method of a targeted therapeutic drug. The multi-stage leaching purification method comprises the following steps: sequentially filling an adsorption column with a porous organic polymer layer and an adsorption ball layer; controlling the flow rate of the leacheate and the column temperature for leaching, and setting an adsorption saturation threshold value; carrier gas is adopted to heat and desorb the porous polymer layer, and carrier gas components are switched to heat and desorb the adsorption ball layer; the method comprises the following steps: introducing carrier gas carrying iodine vapor into an alkaline absorption tower to treat waste gas, eluting impurities of adsorption balls by adopting an acidic mixed solution, and performing catalytic degradation by combining ultraviolet light; a chelating agent solution is used for regenerating adsorption balls, a silver salt solution is used for heavily loading silver ions, an organic solvent is used for eluting and regenerating a porous polymer, regular calibration and part replacement are conducted on a system, and organic pollutants and radionuclides in a matrix are difficult to treat synchronously through a traditional single-layer adsorption material; according to the leaching purification method, the generation amount of radioactive waste liquid is remarkably reduced, and meanwhile the shielding protection requirement of the follow-up purification step is reduced.

Devices and methods for treating joint degeneration (e.g., intervertebral disc degeneration) are provided. An example method may comprise: (1) advancing a tip of an introducer needle into a nucleus pulpous of an intervertebral disc; (2) with the tip of the introducer needle in the nucleus pulpous, maneuvering, out of the tip of the introducer needle, a tip of a flexible needle into a region of a cartilaginous endplate (CEP) of the intervertebral disc; and (3) delivering, from an aperture of the flexible needle, therapeutic to the region of the CEP.

The invention discloses application of tangeretin in preparation of a medicine for treating hearing loss. The invention proposes and verifies that the tangeretin can effectively protect the spiral ganglion neurons for the first time, and avoids the death of the cells caused by cisplatin medication; experimental data show that the preventive tangeretin drug can effectively prevent hearing loss of adult mice and greatly relieve sensorineural deafness caused by cis-platinum, and a new thought is provided for clinical ototoxicity drug administration.

This invention provides a highly pathogenic feline calicivirus strain, its vaccine, and its applications. The highly pathogenic feline calicivirus was isolated from pathogenic material and identified as a highly pathogenic strain, named FCV CC475, with its cDNA sequence shown in SEQ ID NO.1. This strain exhibits strong pathogenicity, causing infected animals to develop symptoms such as fever, paw pad ulcers, and dehydration by day 3 post-infection; the viral load after 5 generations is 10. 9.80 TCID 50 / ml. This strain produces high antibody titers after immunization of cats and rabbits, demonstrating good immunogenicity. Therefore, this highly pathogenic feline calicivirus has broad application prospects in the preparation of feline calicivirus infection vaccines, diagnostic reagents, or therapeutic drugs.

The invention discloses a construction method and application of a rabies virus RNA polymerase dual-luciferase report system, and belongs to the technical field of biology. In order to solve the technical problem that a report system for detecting the RABV RNA polymerase activity needs to be developed urgently, a Firefly luciferase fragment and a vector pcDNA3.1-SRV9-M-G obtained by amplifying M protein and G protein-deleted rabies virus SRV9 strain full-length plasmid are seamlessly connected, a recombinant luciferase report plasmid is constructed, the recombinant luciferase report plasmid and an auxiliary plasmid are combined, and the recombinant luciferase RNA polymerase activity detection system is constructed. And the RABV RNA polymerase dual-luciferase report system is formed by the Renilla luciferase report plasmid and the T7 promoter plasmid, and the RABV RNA polymerase dual-luciferase report system comprises the Renilla luciferase report plasmid and the T7 promoter plasmid. The system can accurately and efficiently detect the activity of RABV polymerase, and by virtue of the function, effective antiviral targets and therapeutic drugs can be screened out in an assisted manner.

The invention discloses application of a compound AZD5718 in preparation of a medicine for preventing and / or treating cholestatic liver diseases, and belongs to the field of biological medicines. The compound AZD5718 can effectively improve hepatocyte damage and bile metabolism disorder caused by Mdr2 gene deletion, provides solid experimental data support for developing novel drugs for treating cholestatic liver diseases, is expected to provide differentiated therapeutic drug choices for clinic, and has important medical value and social significance.

The invention discloses a back cumin treatment method which is used for relieving symptoms of patients with chronic obstructive pulmonary disease and chronic bronchitis. The method comprises the following steps: preparing a cumin ground medicine which comprises 9g of viola tianshanica, 9g of hollyhock seed, 9g of common fenugreek seed, 9g of dill seed, 9g of linseed, 9g of chamomile, 100g of sesame oil or olive oil and other materials, blending the medicine and oil or warm boiled water into a paste at 38-40 DEG C, applying the paste to lung positions (15 * 20cm, 0.3-0.5 cm in thickness) on two sides of the back of a patient, covering the lung positions with a preservative film, irradiating the lung positions with a TDP baking lamp which is not less than 20cm in height for 20-30 minutes, and cleaning the medicine applying positions after the process is finished. Viola tianshanica in the cumin geomedicine can clear away heat and toxic materials, diminish inflammation and relieve pain, hollyhock seeds can clear heat and induce diuresis, and relieve cough and asthma, through the treatment, the medicine efficiently permeates and quickly acts on diseased regions, the symptoms of patients are effectively relieved, and the life quality is improved.

The application discloses a kind of elastin-like polypeptide V 20 K 40 L, mRNA vaccine and preparation method and application in preparation tumor prevention, mitigation or treating drug.The elastin-like polypeptide carrier V 20 K 40 L provided by the application has good biocompatibility, and has no adverse reaction in vivo.The elastin-like polypeptide V 20 K 40 L provided by the application has amphiphilic structure, can be loaded Melan-A mRNA by hydrophobic self-assembly and electrostatic adsorption, and is in the state of shrinkage when higher than Tt temperature, which can prevent the uncontrollable leakage of mRNA.Furthermore, V 20 K 40 L contains lysosome escape peptide, which can further improve the transfection efficiency of mRNA by promoting lysosome escape.The elastin-like polypeptide V 20 K 40 L in the application can deliver Melan-A mRNA efficiently and safely, and realize the prevention and treatment of melanoma.

The application discloses the use of carbon cyanogen - 4 trifluoromethoxy benzyl hydrazone in the prevention and treatment of candida infection, belonging to the technical field of candida infection prevention and treatment. Carbon cyanogen - 4 trifluoromethoxy benzyl hydrazone is used as the only active ingredient for preparing a medicine for preventing or treating diseases caused by candida infection, wherein the candida is candida albicans and / or candida auris; or it is used for preparing a bacteriostatic and / or bactericidal product of candida, wherein the candida is candida albicans and / or candida auris. FCCP shows good inhibition of strain growth, good inhibition of biofilm effect and good mitochondria breaking effect in the antibacterial experiments of various candida (wild type candida albicans, drug resistant candida albicans and drug resistant candida auris). Thus, a new treatment drug for candida albicans and candida auris infection is provided.

The present invention relates to an artificial nucleic acid molecule, a related product thereof and use thereof in the preparation of a medicament for DNA or RNA-based therapy, and to the use of a 3 '-untranslated region element (i.e., 3'-UTR) in said artificial nucleic acid molecule for translating a coding region of a nucleic acid molecule into a polypeptide or protein encoded by said coding region, and a method of obtaining RNA, polypeptide or protein. According to the present invention, the specific 3 '-UTR element capable of improving the RNA translation performance is included, such that the artificial nucleic acid molecule has the high RNA translation performance so as to provide the high potential value and the high application prospect in the development of the RNA treatment drug.

Nanoparticles are provided having a calcium core, such as calcium hydroxide (Ca (OH) 2) and calcium carbonate (CaCO3) particles. The nanoparticles may further include a shell, such as a shell formed from silica or oleic acid. The nanoparticles may further include a coating, such as a coating formed from polyethylene glycol, and optionally further include a coating of lipids. The nanoparticles may further include a targeting agent, such as a targeting agent that targets dendritic cells, T cells, or other immune cells. The nanoparticles may further include or otherwise be used in combination with an active agent, optionally selected from the group consisting of an antigen, a chemotherapeutic drug, an immune system modulator or an immune checkpoint modulator. Also provided are pharmaceutical compositions comprising the nanoparticles and methods of use thereof for increasing an immune response against, for example, cancer and infection.

The invention discloses a medicinal and edible composite particle capable of relieving liver injury and a preparation method and application thereof.The particle is a puerarin-loaded phosphorylated hollow zein-chitosan oligosaccharide particle and has an efficient delivery structure with the exterior hydrophilic and the interior hydrophobic, the bioavailability is improved while the puerarin drug loading capacity is increased, and the bioavailability is improved. The circulation time in the body is prolonged, and the medicinal effect is enhanced. Meanwhile, the chitosan oligosaccharide in the components of the composite particle has a liver protection effect and can be cooperated with the anti-oxidation and anti-alcohol characteristics of puerarin, so that multi-target protection in alcoholic liver injury is realized, and the composite particle can be used for expanding and developing treatment medicines or health-care foods with anti-alcohol and liver-protecting effects and has remarkable economic and social values.

This invention discloses a method for preparing and applying a photothermal nanoreagent targeting bacteria. This invention utilizes Ti3C2T... x Using MXene as a matrix, a photothermal nanoreagent MXene@PDA@Peptide (MPP) was constructed by sequentially modifying the surface of Ti3C2Tx MXene with polydopamine and grafting it with the peptide CAEKA, which has the function of recognizing bacteria. Under the recognition of the peptide CAEKA, the photothermal Ti3C2Tx MXene was targeted. x MXene nanosheets are guided to the surface of bacterial cells, achieving effective sterilization at a relatively low overall temperature of around 50°C (or achieving more efficient sterilization at the same overall temperature level, exhibiting superior sterilization performance compared to pure Ti3C2Tx MXene). This makes them particularly suitable for the preparation of therapeutic drugs for subcutaneous abscesses caused by methicillin-resistant Staphylococcus aureus (MRSA) infection.

The invention discloses an application of rhBMP9 in preparation of a medicine for treating idiopathic pulmonary fibrosis related pulmonary arterial hypertension, the rhBMP9 protects pulmonary vascular endothelial cells, inhibits endothelial cell apoptosis and improves pulmonary vascular remodeling by up-regulating BMP9 / BMPR2 / SMAD signal pathways so as to treat IPF-PH, the invention further provides various dosage forms and administration routes of the rhBMP9 medicine, and the rhBMP9 medicine can be used for preparing the medicine for treating the idiopathic pulmonary fibrosis related pulmonary arterial hypertension. According to the application of the rhBMP9 and the drug combination scheme of the rhBMP9 and other IPF treatment drugs, animal experiments show that the rhBMP9 can remarkably improve hemodynamic parameters and lung tissue pathological changes of an IPF-PH model, and a new strategy is provided for clinical treatment of IPF-PH.

The present invention provides a new synthesis method of Parovide, a therapeutic drug for the new coronavirus. Wherein, the synthesis method of the intermediate 6,6-dimethyl-3-azabicyclo (3.2.0) hexane hydrochloride, the steps include nitrogen protection, reduction reaction, quenching, extraction, salification, and deprotection. The Parovide intermediate 6,6-dimethyl-3-azabicyclo (3.2.0) hexane hydrochloride synthesized by this method has the characteristics of high yield, few impurities, safe reaction, simple operation, and no special requirements for equipment, thereby being more conducive to the synthesis of high-quality Parovide, a therapeutic drug for the new coronavirus.

The invention discloses a protein ADGRE2-targeted acute myelogenous leukemia treatment medicine and application, and relates to the technical field of biomedicine. The invention provides an application of a drug targeting protein ADGRE2 in preparation of a drug for preventing and / or treating acute myelogenous leukemia. The protein ADGRE2 is highly specifically expressed on the surface of an acute myelogenous leukemia cell membrane, and the targeted protein ADGRE2 can inhibit the proliferation ability and migration ability of acute myelogenous leukemia cells and promote the apoptosis of the acute myelogenous leukemia cells. Meanwhile, the protein ADGRE2 can be used as an effective drug target for CAR-T cell therapy, guides the development of novel CAR-T cells, and is expected to promote the novel target CAR-T cell therapy for acute myelogenous leukemia to make a major breakthrough.

The invention discloses a traditional Chinese medicine monomer composition derived from chrysanthemum plants and used for treating diabetic retinopathy as well as a preparation method and application of the traditional Chinese medicine monomer composition. The traditional Chinese medicine monomer composition prepared from the chrysanthemum plant as the raw material is high in safety, small in side effect and definite in component and is prepared according to a specific ratio, and pharmacodynamic experiments prove that compared with an ethanol extract, the traditional Chinese medicine monomer composition is more remarkable in curative effect on diabetic retinopathy, and the curative effect of the traditional Chinese medicine monomer composition on diabetic retinopathy is better than that of a traditional Chinese medicine composition on diabetic retinopathy. The composition can improve the pathological state of diabetic retinopathy from multiple targets and multiple ways, specifically can inhibit body mass increase caused by high glucose, reduce blood glucose level, improve retinal tissue structure damage, recover retinal tissue thickness, inhibit retinal cell apoptosis and inflammatory response, reduce the expression level of HIF-1alpha and VEGF protein in retinal tissue, and can be used for treating diabetic retinopathy. Scientific basis and technical support are provided for research and development of novel drugs for treating the diabetic retinopathy, and important clinical significance and market application prospects are achieved.

The invention discloses a traditional Chinese medicine composition for scalds and burns as well as preparation and application thereof, and belongs to the technical field of traditional Chinese medicine treatment. The traditional Chinese medicine composition is prepared by combining raw materials including barks of barks of portulaca oleracea, barks of rubus corchorifolius, carbon crystals (coal crystals) and borneol according to a specific weight ratio, and raw tung oil is used as a matrix carrier. The preparation process is completed through the steps of raw material purification, drying, nanoscale crushing, precise proportioning, mixing and screening and the like, and the product is fine and uniform nanoscale powder. The traditional Chinese medicine composition is scientific and reasonable in formula, simple and controllable in preparation process and convenient and safe in medication mode, solves the problems of slow healing, obvious scars, easy infection, large side effects and the like of existing scald and burn treatment medicines, is suitable for various scenes such as family emergency, clinical medical treatment and outdoor operation, and has extremely high popularization and application values.