490 results about "Treatment medication" patented technology

To provide systems and methods suitable for delivering a therapeutic agent to a target site.SOLUTION: The system comprises a container for holding the therapeutic agent, and a pressure source having pressurized fluid, where the pressure source is in selective fluid communication with at least a portion of the container. A catheter is placed in fluid communication with the container, and has a lumen sized for delivery of the therapeutic agent to a target site. A housing is configured to securely retain the container. The system further comprises a camera having a camera head coupled to the catheter, where the camera provides a visual image of the target site during the delivery of the therapeutic agent.SELECTED DRAWING: Figure 1

The invention discloses an application of an Ms-Piscidin antibacterial peptide in preparation of a largemouth bass rhabdovirus inhibitor or a treatment drug, and is characterized by providing an application of the Ms-Piscidin antibacterial peptide in preparation of the largemouth bass rhabdovirus inhibitor and an application of the Ms-Piscidin antibacterial peptide in preparation of the treatment drug for largemouth bass rhabdovirus infection. The amino acid sequence of the Ms-Piscidin antibacterial peptide is as shown in SEQ ID NO.1: FLKHIKSFWRGAKAIFRGARQGWREHR. The Ms-Piscidin antibacterial peptide has the advantages that the Ms-Piscidin antibacterial peptide can inhibit MSRV proliferation, the survival rate of micropterus salmoides infected by MSRV is increased, and the Ms-Piscidin antibacterial peptide can be used as a potential medicine for preventing and treating MSRV infection diseases.

The invention relates to an application of Danjie emodin in preparation of drugs for preventing or treating drug-induced liver injury. The liver injury is drug-induced liver injury induced by acetaminophen. According to the invention, the effective component Danleaf emodin in the traditional Chinese medicine rhubarb is used for preventing and treating drug-induced liver injury induced by acetamido, and the traditional Chinese medicine composition has the characteristics of safety, reliability and small toxic and side effects. Starting from the whole, multi-target intervention is performed on drug-induced liver injury induced by acetaminophen, the levels of glutamic-pyruvic transaminase, glutamic oxalacetic transaminase and malondialdehyde in plasma are remarkably reduced, the obvious anti-inflammatory and liver cell apoptosis inhibiting effects are achieved, the good clinical application prospect is achieved, and a new way is provided for prevention and treatment of liver injury.

The invention aims to provide a preparation method and application of an inhalation drug-loading ultrasonic driving nano motor, and can effectively solve the problems of preparation of the inhalation drug-loading ultrasonic driving nano motor and application of the inhalation drug-loading ultrasonic driving nano motor in preparation of drugs for treating IPF. Comprising the following steps: firstly preparing PLGA-PFD nanoparticles, then preparing PDA-PLGA-PFD nanoparticles, and finally preparing BNN6 / PDA-PLGA-PFD, namely the asymmetric nano motor BPPP with the ultrasonic responsiveness. The product disclosed by the invention is scientific and advanced in preparation method, good in product performance, high in atomization administration and IPF lung pathological barrier penetrating capability, high in medicine utilization rate, good in curative effect, simple and convenient to operate, wide in application prospect and huge in economic and social benefits.

The invention discloses an application of core proteoglycan or a coding gene thereof as a target spot in preparation of psoriasis treatment drugs, and a series of experiments prove that DCN can effectively protect mouse psoriasis-like dermatitis induced by imiquimod, improve skin scale, erythema, thickening and epidermal abnormal differentiation, enhance the barrier function of skin, improve the curative effect of psoriasis, and improve the curative effect of psoriasis. A large amount of infiltration of inflammatory cells is reduced, and a certain anti-inflammatory effect is achieved. Experimental research shows that the DCN has an obvious drug effect on a psoriasis model, is safe and efficient, has no side effect, is simple in production process and has the potential of realizing medical transformation. And the potential application value of the DCN on other various skin inflammatory diseases can be expanded.

The invention provides a bending-adjustable balloon micro-catheter, and belongs to the technical field of balloon micro-catheters.The bending-adjustable balloon micro-catheter comprises a catheter body, a balloon, a bending mechanism and a feedback mechanism, the catheter body is of a slender tubular structure, and an inner cavity of the catheter body is used for conveying therapeutic drugs or embolism materials or other media; the balloon is located at the far end of the catheter body, is in an ellipsoidal shape and is used for blocking blood flow or expanding blood vessels. The multiple bending mechanisms are sequentially located at the middle section position of the catheter body and are composed of shape memory alloy wires, and the shape memory alloy wires are spirally wound around the outer wall of the catheter body, connected to the catheter body and used for adjusting the bending angle and direction of the catheter body; the feedback mechanisms are pressure sensor arrays, and the number of the feedback mechanisms is eight. The problems that an existing balloon micro-catheter is difficult to accurately reach a target position in a complex blood vessel or cavity, and the blood vessel is prone to being damaged can be solved.

The invention provides a digital intelligent robot for health risk assessment based on big data, and belongs to the field of health assessment. The problem of low health assessment efficiency is solved; the specific evaluation system comprises an information acquisition module for acquiring pre-diagnosis information; the medical record analysis module is used for acquiring pathological data, calculating a benign treatment cycle and malignant treatment of each disease, and constructing a benign lesion equation and a malignant lesion equation of each disease; the patient diagnosis module is used for determining disease names and treatment drugs of the patients, acquiring to-be-analyzed parameters, and analyzing pathological changes and diseased time of the patients in combination with benign lesion equations and malignant lesion equations corresponding to the disease names to obtain a pre-diagnosis report; the physician interaction module is used for feeding back a pre-diagnosis report; by acquiring, processing and analyzing the relevant information of the pathology of the patient, the disease and disease change of the patient are determined, and the treatment of the patient is facilitated.

The invention relates to the technical field of medical instruments, in particular to a balloon delivery microcatheter and a using method thereof.The microcatheter comprises a handle, a balloon delivery pipe, a balloon delivery pipe and a balloon delivery pipe, the catheter body is connected with the handle, and the catheter body sequentially comprises a near-end tube, a balloon tube and a far-end tube from near to far; wherein the catheter body is of a double-cavity structure and comprises an inner cavity and an outer cavity, the inner cavity is a channel, one end of the inner cavity is communicated with the first connector, and the other end of the inner cavity penetrates to the end of the far-end tube and is used for conveying instruments, therapeutic drugs or diagnostic radiography liquid; one end of the outer cavity is communicated with the second connector, the other end of the outer cavity is communicated with the balloon tube, and the outer cavity is used for filling and pressure relief of the balloon tube. The balloon catheter has the functions of a micro catheter and a balloon catheter, a near-end blood vessel can be blocked, temporary blocking of local blood flow is achieved, the balloon catheter is further used for expanding the position, not attached to the wall, of an intravascular stent, the stent can be better attached to the blood vessel wall, and therefore pain and risks of a patient are reduced.

The present invention provides a novel therapeutic drug for treating a Prom1-associated retinal disease. Specifically, the present invention provides an optimized Prom1 gene expression cassette, an rAAV viral vector, and a gene therapy drug. The drug of the present invention can specifically express the PROM1 protein in the retinal photoreceptor layer, and is suitable for the clinical treatment of a retinal disease associated with Prom1 gene mutation.

The invention relates to the field of biomedicine, particularly provides a copper-based nano-enzyme as well as a preparation method and application thereof, and aims to solve the problems that in the prior art, clinical treatment on primary sclerosing cholangitis (PSC) is difficult in diagnosis and lacks of effective treatment drugs. The copper-based nano-enzyme comprises a nano-enzyme carrier and a copper-based nano-enzyme, wherein the nano-enzyme carrier is a two-dimensional nanosheet formed by copper ions, gallic acid and ursodesoxycholic acid through coordinate bonds; the probe molecule is a cyanine dye molecule connected to the surface of the nano-enzyme carrier through a covalent bond; wherein the fluorescence intensity of the copper-based nano enzyme is enhanced after the action of the alkaline phosphatase. The three functions of alkaline phosphatase responsive diagnosis, nano-enzyme catalytic treatment and ursodesoxycholic acid hepatic targeting are innovatively and synergistically integrated into one nano platform, the treatment function can be executed while specific imaging diagnosis is performed on diseases, and a new strategy is provided for diagnosis and treatment of diseases such as PSC.

The invention relates to the fields of biology, medicine and clinic. In particular to application of PAICS as a target spot in developing or screening reagents for preventing and / or treating orthopoxvirus infection, and application of inhibiting a synthetic pathway of purine nucleotide and / or inhibiting a metabolic pathway of folic acid in preparing reagents for treating and / or preventing orthopoxvirus infection diseases. In order to restrain the infection of orthopoxvirus, the inventor team uses a CRISPR / Cas9 technology to carry out generic genome screening on host cells infected by orthopoxvirus, determines a host-dependent gene PAICS gene in the orthopoxvirus infection process, and verifies and clarifies the virus-dependent mechanism of the gene; in order to deal with the global continuous orthopoxvirus infection problem, the invention plays an important role in the development and screening of future related prevention or treatment drugs, and also expands the new clinical application of existing drugs including methotrexate, mercaptopurine, mizoribine and the like.

The invention discloses nano-particles with antibacterial and osteogenesis promoting effects as well as a preparation method and application of the nano-particles, and belongs to the technical field of antibacterial nano-materials. On one hand, the invention provides the nano-particles with antibacterial and osteogenesis promoting effects and the preparation method thereof, and on the other hand, the invention provides the application of the nano-particles. The nanoparticles obtained by the method disclosed by the invention have good stability under physiological conditions (PH = 7.4); polyphenol, metal ions and AMP (adenosine monophosphate) can be slowly released in an inflammatory (weakly acidic) environment, and the functions including but not limited to bacterium capturing, bacterium killing, inflammation and oxidation resisting, osteogenesis promoting and the like are realized; the nano-particles can be used for preparing a bone infection treatment drug, and the bone infection treatment drug has a broad-spectrum antibacterial effect and cannot cause antibiotic drug resistance; the treatment medicine can efficiently prevent and treat bone infection and improve bone repair efficiency.

The invention discloses application of GSK2606414 in preparation of a medicine for inhibiting duck tembusu virus infection, and belongs to the technical field of veterinary biological products. The research finds that the GSK2606414 can effectively inhibit the replication of the duck tembusu virus for the first time, provides a new therapeutic drug for the prevention and treatment of the duck tembusu virus, and is of great significance to the actual production of the poultry breeding industry.

The utility model discloses an infusion tube flow statistical device, and mainly relates to the technical field of infusion tube flow devices. Comprising a liquid conveying pipeline, the arc surface of one end of the liquid conveying pipeline is slidably connected with an adjuster, a flow meter is installed on the surface of the end, away from the adjuster, of the liquid conveying pipeline and comprises a flow displayer, a flow laser velometer and a flow warmer, and an adjusting device is arranged at the position, corresponding to the flow meter, of the arc surface of the liquid conveying pipeline. The adjusting device comprises a bearing plate, and the bottom face of the bearing plate abuts against the surface of the liquid conveying pipeline. The infusion metering device has the advantages that the problems that in the treatment process of a patient in a hospital, various infusion tubes are used for conveying treatment medicine, flow control over infusion medicine is crucial, infusion metering in the hospital is generally displayed and regulated through an infusion pump, and the infusion pump is large in overall size, so that the infusion metering device is inconvenient to use and the like are solved. And convenience and rapidness in adjustment by medical staff are avoided.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to application of a traditional Chinese medicine composition in preparation of anti-hepatoma medicines. The traditional Chinese medicine composition comprises red ginseng, ox horn tip, musk, borneol, safflower, bezoar, radix aconiti lateralis praeparata slice, venenum bufonis, pseudo-ginseng, benzoin and pearl. Experimental results show that the traditional Chinese medicine composition can induce apoptosis and necrosis of liver cancer cells and inhibit proliferation of the liver cancer cells; and liver cancer cells are retarded to be in a G1 cell cycle. Therefore, the invention provides a new therapeutic drug for clinical treatment of liver cancer, and the raw materials are natural medicinal materials, have wide sources and have good application prospects.

The invention discloses a preparation method of a cochlear organ chip integrated with a blood labyrinth barrier, and belongs to the field of biomedical engineering. The preparation method of the simulated blood labyrinth barrier comprises the following steps: constructing an endothelial cell culture cavity and a pericyte culture cavity, and separating the endothelial cell culture cavity and the pericyte culture cavity through a simulated basement membrane; and respectively inoculating percutaneous cells and endothelial cells into a percutaneous cell culture cavity and an endothelial cell culture cavity, and culturing to obtain the simulated blood lost barrier. The chip can effectively simulate the structure and the function of the BLB, and the barrier integrity of the BLB is evaluated through TEER (trans-epithelial electrical resistance) measurement and an apparent permeability coefficient. The invention also relates to application of the chip in NIHL drug screening, in particular to drug evaluation for oxidative stress induced inner ear organ injury. Through the platform, the protection effect of the candidate drugs on the TBHP-induced oxidative stress injury of the inner ear organs can be evaluated, and a new tool and thought are provided for developing novel NIHL treatment drugs.

The invention provides application of arabian jasmine flower lactone in preparation of a medicine for resisting senescence caused by microgravity. The arabian jasmine flower lactone can inhibit dissolution and / or deconstruction of F-actin caused by microgravity, stabilize cytoskeleton, and further inhibit or delay the aging process under microgravity. The invention also provides application of the arabian jasmine flower lactone in preparation of medicines for preventing and / or treating space diseases. The arabian jasmine flower lactone can inhibit organ and / or cell function decline caused by weightlessness in a space environment.

The present invention relates to a damaged skin organoid model and a drug screening method using same, and is a technology that uses a technique for producing an air-liquid interface skin organoid, in which skin cells, appendages, nerve cells, adipocytes, and the like are formed as a structure similar to actual skin, and which produces damaged skin by irradiating the skin organoid with ultraviolet rays that simulate ultraviolet radiation reaching the earth's surface. In the present invention, by irradiation with simulated solar ultraviolet rays including 94.5% of UV-A and 5.5% of UV-B, the skin barrier was damaged and collagen degradation was promoted by increasing the activity of matrix metalloproteinases, and, at the same time, the characteristics of UV-damaged skin, such as increased secretion of pro-inflammatory cytokines, were successfully mimicked. Therefore, it is determined that the present invention will be effectively used as a UV-induced damage and photoaging model, and will serve as a useful technology for screening for potential therapeutic drugs.

The invention provides a new target for treating metabolism-related fatty liver diseases, a regulation molecule and application thereof. The invention discloses a novel target gene closely related to relieving or treating the metabolism-related fatty liver disease and a signal channel related to upstream and downstream regulation and control of the target gene for the first time. The invention discloses a new mechanism participated by the signal channel and used for regulating and controlling the metabolism-related fatty liver disease. Preferred remission / therapeutic agents are also disclosed.

A cage type support for bone grafting capable of achieving heat balance comprises a support shell and a base, and a multipurpose cavity is formed in the base. The inner cavity of the bracket shell is communicated with the multi-purpose chamber through a heat convection pipe group; the multipurpose cavity is configured to be a heat dissipation end communicated with the inner cavity, and heat balance of the inner cavity and the multipurpose cavity is achieved through a heat convection pipe set communicated between the multipurpose cavity and the inner cavity; a stable supporting foundation is provided, the osseointegration process is promoted, heat balance of the whole stent is achieved, the internal temperature of the femoral head is properly increased, local blood circulation of the femoral head is accelerated, cell activity is enhanced, metabolism is accelerated, proliferation and differentiation of related cells such as bone cells are promoted, angiogenesis and bone repair are promoted, and gas exchange is facilitated. The implant can be used for promoting the discharge of hydrops and pneumatosis, continuously releasing intraosseous pressure and providing a storage space and path for therapeutic drugs and / or nutritional ingredients, and the implant realizes multi-system collaboration and promotes overall rehabilitation.

The present invention relates to RNA molecules, and particularly, although not exclusively, to methods for preparing RNA molecules, and to methods for translating RNA molecules into protein. The invention extends to improved methods for forming RNA by in vitro transcription, and to the resultant RNA molecules. Furthermore, the invention relates to novel methods for enhancing the expression and / or translation of RNA, i.e. protein expression, and to methods for improving the stability of an RNA molecule. The invention also involves reducing the activation of innate sensing, interferon generation and / or degradation of an RNA molecule in a host. The invention also incorporates the use of the RNA molecules in vaccines and other therapeutic pharmaceutical compositions, and their use in immunisation and therapy, such as RNAi, gene therapy, gene editing and protein replacement. In particular, the invention relates to locked nucleotides and locked nucleic acid (LNA)-RNA molecules, and the use or incorporation of such locked nucleotides and LNA-RNA molecules in any of the above applications.

The invention provides a novel therapeutic drug for treating Prom1 related retinal diseases. Specifically, the invention provides an optimized Prom1 gene expression cassette, an rAAV virus vector and a gene therapy drug. The medicine provided by the invention can specifically express the PROM1 protein in a retina photoreceptor layer, and is suitable for clinical application to treatment of Prom1 gene mutation related retinal diseases.

The invention provides a gene therapy drug for treating AMD (Amplified Maleic Disease). The invention provides an anti-VEGF fusion protein with a specific secretion signal peptide sequence. The anti-VEGF fusion protein can effectively express and secrete an anti-VEGF protein. The invention also provides a modified AAV vector for improving the retinal transduction efficiency of the anti-VEGF protein. The fusion protein and the modified AAV vector can be used for treating neovascular eye diseases.

The invention relates to a crystal form of a compound I, a preparation method of the crystal form, and application of the crystal form in preparation of iron deficiency related treatment medicines for treating anemia accompanied with or not accompanied with iron deficiency. The novel crystal form of the compound I provided by the invention has the advantages of high solubility, good chemical stability, solid stability, mechanical stability and humidity stability, simple preparation method, easiness in crystal form control, low production amplification cost and the like, and has important value for development of the medicine in the future. # imgabs0 #

According to the silk fibroin hydrogel microneedle manufacturing method and the hydrogel microneedle, a silk fibroin solution and a riboflavin aqueous solution are evenly mixed to obtain a mixed solution, then a hydrogen peroxide solution is added into the mixed solution to be mixed to obtain a precursor solution, then the precursor solution is poured into a light-transmitting microneedle mold, and the silk fibroin hydrogel microneedle is obtained. Placing a microneedle mold containing the precursor solution into a vacuum pump, performing vacuum pumping treatment, taking out the microneedle mold, placing the microneedle mold under ultraviolet irradiation for illumination to form a gel, drying the gel at room temperature, taking out the gel from the microneedle mold, forming a plurality of convex cones on the outer surface of the gel, and performing vacuum pumping treatment on the cones to obtain the composite microneedle. The silk fibroin hydrogel microneedle is obtained. According to the design, the operation requirement is low, the slow release effect is good, the biocompatibility is high, and efficient carrying of treatment medicine is facilitated.

A portable emergency response kit designed for rapid intervention in opioid overdose or cardiac arrest scenarios comprises a durable case with compartments for specific medical devices, such as opioid overdose treatment medication or an Automated External Defibrillator (AED). The case features a breakable closed circuit that is, upon opening, triggered to send a signal to notify emergency medical services (EMS) or predefined contacts of the kit's location.The system utilizes GPS module and may include dual-mode communication capabilities for reliable alert transmission in various environments. Additional features may include a transparent case material for visual confirmation of contents, tamper-evident seals, QR codes linked to instructional content, and a battery power source. The kit is designed to be user-friendly, incorporating ergonomic elements and optional accessories for enhanced portability and storage, ensuring rapid and effective response in critical situations.

The invention discloses a multi-stage leaching purification method of a targeted therapeutic drug. The multi-stage leaching purification method comprises the following steps: sequentially filling an adsorption column with a porous organic polymer layer and an adsorption ball layer; controlling the flow rate of the leacheate and the column temperature for leaching, and setting an adsorption saturation threshold value; carrier gas is adopted to heat and desorb the porous polymer layer, and carrier gas components are switched to heat and desorb the adsorption ball layer; the method comprises the following steps: introducing carrier gas carrying iodine vapor into an alkaline absorption tower to treat waste gas, eluting impurities of adsorption balls by adopting an acidic mixed solution, and performing catalytic degradation by combining ultraviolet light; a chelating agent solution is used for regenerating adsorption balls, a silver salt solution is used for heavily loading silver ions, an organic solvent is used for eluting and regenerating a porous polymer, regular calibration and part replacement are conducted on a system, and organic pollutants and radionuclides in a matrix are difficult to treat synchronously through a traditional single-layer adsorption material; according to the leaching purification method, the generation amount of radioactive waste liquid is remarkably reduced, and meanwhile the shielding protection requirement of the follow-up purification step is reduced.

The invention belongs to the field of medicinal chemistry, and particularly relates to application of specific spiro chalcone compounds in preparation of neuroprotective drugs and drugs for treating nerve injury related diseases, and the spiro chalcone compounds can antagonize cell excitatory injury and cell apoptosis caused by amino acid. In a middle cerebral artery occlusion (MCAO) mouse model, E38 can reduce cerebral infarction area, improve neurological score and alleviate retinal ganglion cell (RGC) injury. In an optic nerve pinch injury model, the X38 can effectively improve retinal thinning and optic nerve electrophysiological function loss caused by optic nerve injury.

The utility model relates to the field of organ chips, in particular to a micro-fluidic platform for screening tumor individualized treatment drugs. The micro-fluidic platform comprises a chip which comprises an upper-layer chip and a lower-layer chip, a first channel, a first-stage mixing structure, a second channel, a second-stage mixing structure, a first cell culture area and a third channel which are communicated in sequence are arranged on the upper-layer chip, a medicine inlet is formed in the first channel, and a discharge port is formed in the third channel; the lower-layer chip is provided with a second cell culture area, and the second cell culture area is arranged corresponding to the first cell culture area; a temperature control device is arranged on the lower surface of the lower-layer chip and comprises a heating film, an isolation layer and a power source, and the heating film is arranged on the isolation layer and electrically connected with the power source. According to the utility model, the temperature control device is arranged, so that the chip can be continuously heated when cell observation is needed, the temperature of the chip is always maintained at 37 DEG C, and the accuracy of an experiment can be ensured.

Devices and methods for treating joint degeneration (e.g., intervertebral disc degeneration) are provided. An example method may comprise: (1) advancing a tip of an introducer needle into a nucleus pulpous of an intervertebral disc; (2) with the tip of the introducer needle in the nucleus pulpous, maneuvering, out of the tip of the introducer needle, a tip of a flexible needle into a region of a cartilaginous endplate (CEP) of the intervertebral disc; and (3) delivering, from an aperture of the flexible needle, therapeutic to the region of the CEP.