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Film coating agent for wound surface treatment and preparation method of film coating agent

A film coating agent and wound surface technology, applied in the field of medicine, can solve the problems of poor air permeability of adhesive tape, local skin soaking, poor selectivity, etc., and achieve the effects of good bacteriostatic effect, convenient use and reduction of allergic reactions.

Active Publication Date: 2015-01-07
KUNMING YUANRUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Band-Aids have a fixed size, and have poor selectivity to wounds of different sizes and properties, and the external adhesive tape has poor air permeability, and the water vapor and sweat normally secreted by the human body cannot penetrate this layer of adhesive tape, which will soak the local skin; in addition, the Band-Aid is waterproof Poor performance, and affect the normal life of patients after use

Method used

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  • Film coating agent for wound surface treatment and preparation method of film coating agent
  • Film coating agent for wound surface treatment and preparation method of film coating agent
  • Film coating agent for wound surface treatment and preparation method of film coating agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: the preparation of film coating agent

[0037] (1) Prescription composition:

[0038] The prescription composition of table 1 coating agent

[0039]

[0040] In prescriptions 1-5, polyvinyl alcohol 2488 can be replaced by sodium alginate, polyvinyl formal, polyvinyl butyral, carbomer, sodium carboxymethylcellulose and hypromellose . Sodium ethylparaben also includes a reasonable amount of coloring or flavoring.

[0041] (2) The preparation method of the coating agent of prescription one to prescription five:

[0042] 1. Dissolve the prescribed amount of preservative with an appropriate amount of water to prepare solution 1;

[0043] 2. Put the prescribed amount of polyvinyl alcohol 2488 and water-soluble chitosan in a suitable container, add the remaining prescribed amount of distilled water to it, stir and mix evenly while adding, add the prescribed amount of glycerin after swelling for 30 minutes, and gradually heat up While stirring to 80°C, unt...

Embodiment 2

[0046] Embodiment 2: the bacteriostasis experiment of coating agent

[0047] (1) Strain: Staphylococcus aureus CMCC (B) 26003] 4th generation; (Note: provided by Guangdong Microbial Culture Collection Center)

[0048] (2) Preparation of bacteria solution: take the above Staphylococcus aureus and use 0.9% sterile sodium chloride solution to make a bacteria suspension containing 50-100 cfu of bacteria per 1 ml.

[0049] (3) test product test group: get a certain amount of film-coating agent prepared by prescription one to prescription five of embodiment 1 and the above-mentioned bacterial suspension (50~100cfu / ml) of 1ml and inject in the petri dish, pour into nutrient agar culture medium immediately. Prepare 2 flat plates in parallel for each batch of test samples, culture them at 30-35°C for 3 days, and then measure the number of bacteria according to the plate method.

[0050] Viable bacteria group: Take 1ml (50-100cfu / ml) of the above-mentioned bacteria suspension and injec...

Embodiment 3

[0058] Embodiment 3: the preparation of coating agent

[0059] (1) Prescription composition:

[0060] The prescription composition of table 3 coating agent

[0061]

[0062]

[0063] In prescriptions 6-10, polyvinyl alcohol 2488 can be replaced by sodium alginate, polyvinyl formal, polyvinyl butyral, carbomer, sodium carboxymethylcellulose and hypromellose . Sodium ethylparaben also includes a reasonable amount of coloring or flavoring. The water can be deionized or distilled.

[0064] (2) The preparation method of the coating agent of prescription six to prescription ten:

[0065] 1. Dissolve the prescribed amount of preservative with an appropriate amount of water to prepare solution 1.

[0066] 2. Put the prescribed amount of polyvinyl alcohol 2488 and water-soluble chitosan in a suitable container, add the remaining prescribed amount of water to it, stir and mix evenly while adding, add the prescribed amount of glycerin after swelling for 30 minutes, and gradual...

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Abstract

The invention discloses a film coating agent for wound surface treatment and a preparation method of the film coating agent. The film coating agent comprises chitosan, a film-forming material, a plasticizer and a solvent, wherein the plasticizer is glycerin with the amount accounting for 2-15% of the total weight of the film coating agent. The film coating agent has the advantages that the film coating agent is better in antibacterial effect, more convenient to use and better in waterproofness, is not limited by shapes and sizes of skin wound surfaces, does not affect normal limb movement and the like.

Description

technical field [0001] The invention relates to a film-coating agent for treating wounds and a preparation method thereof. The film-coating agent is suitable for the treatment of superficial wounds on the skin surface, surgical wounds, burn wounds and ulcer wounds, and belongs to the technical field of medicine. Background technique [0002] The skin is the largest organ of the human body and one of the most important organs of the human body. It mainly undertakes the functions of protecting the body, perspiration, and feeling cold, heat and pressure; the skin covers the whole body, and it protects various tissues and organs in the body from physical, Mechanical, chemical and pathogenic microbial attacks. At the same time, skin trauma is also a common surgical disease. Factors such as burns, scalds, knife wounds, infections, drugs, and immune responses in daily life may damage the skin tissue. On the one hand, the wound surface caused by skin trauma is easy to cause bleedin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/722A61P17/02
Inventor 王高华
Owner KUNMING YUANRUI PHARMA
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