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Muscular amino acid and peptide nucleoside powder injection and its preparation method

A technology for carnosin glycoside powder and powder injection, which is applied to the field of carnosine glycoside powder for injection and its preparation, can solve the problems that the content of nucleoside substances cannot meet the demand and the yield is not high, and achieves easy industrial production and preparation method. Simple and safe to use

Inactive Publication Date: 2004-08-25
黑龙江江世药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 2) Due to the simple preparation process of sarcosaminopeptide glycoside solution, the yield is not high, and the content of nucleosides often cannot meet the requirements, and additional

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] (1) Take 1000 grams of rabbit myocardium and muscle (the ratio of muscle to heart is 4:1), wash the frozen or fresh myocardium and muscle with pure water until bloodless at 10°C, and then put them in a meat grinder to grind broken.

[0069] (2) The minced tissue was mixed with cold water for injection at a ratio of 1:0.8 to make a homogenate, frozen at -18°C for 20 hours, and then frozen and thawed 4 times in total.

[0070] (3) After thawing the frozen homogenate, coarsely filter, heat the filter to 80°C and keep it for 5 minutes, then quickly cool down to room temperature, centrifuge, and filter the supernatant with a microporous membrane (0.45 μm) to obtain a clear filtrate.

[0071] (4) The filtrate is ultrafiltered with an ultrafiltration membrane (relative molecular cut-off value is 8000), and the filtrate is collected to obtain the carnosine glycoside solution. According to the content of polypeptide and hypoxanthine in the solution, 5g of excipient solution is a...

Embodiment 2

[0074] (1) Take 1800 grams of rabbit myocardium and muscle (the ratio of muscle to heart is 10:1), wash the frozen or fresh myocardium and muscle with pure water at 10°C until bloodless, then put them in a meat grinder and grind them. broken.

[0075] (2) The minced tissue was mixed with cold water for injection at a ratio of 1:2 to make a homogenate, frozen at -22°C for 26 hours, and then frozen and thawed 7 times in total.

[0076] (3) After thawing the frozen homogenate, coarsely filter, heat the filter to 85°C and keep it for 8 minutes, then quickly cool down to room temperature, centrifuge, and filter the supernatant with a microporous membrane (0.22 μm) to obtain a clarified filtrate.

[0077] (4) The filtrate is ultrafiltered with an ultrafiltration membrane (relative molecular cut-off value is 6000), and the filtrate is collected to obtain a sarcosaminoglycan glycoside solution. According to the content of polypeptide and hypoxanthine in the solution, 80 g of excipient...

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PUM

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Abstract

The present invention relates to a sarcopeptidoglucoside powder injection and its preparation method. It is formed from polypeptide, hydroxanthine and excipient. Said invention adopts the modern biological extraction technique to prepare sarcopeptidoglucoside solution, and utilizes the modern low-temp. freeze-drying preparation technique to obtain the invented sterile freeze-dried powder injection. When it is used, it can be dissolved by injection water or infusion fluid, then can be injected. Said invention has good stability, long storage time and high safety, etc.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a carnosine glycoside powder injection and a preparation method thereof. Background technique [0002] Carnosine glycoside injection is a drug used to treat diseases of the cardiovascular and cerebrovascular systems. This product has the effects of improving blood circulation disorders, reducing vascular resistance, increasing the use of oxygen by the myocardium, promoting the activity of the hematopoietic system, increasing the number of white blood cells, increasing the elasticity of blood vessels, and preventing hardening of the arteries. The main disadvantages and deficiencies of the existing carnosine glycoside injection: [0003] 1) Since sarcosaminoglycan injection contains biologically active substances such as polypeptides, amino acids, and nucleotides, it is easily affected by environmental factors during transportation and storage, and changes such as oxidation, polymer...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K38/16A61P9/10
Inventor 江卫世
Owner 黑龙江江世药业有限公司
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