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73 results about "Transcription initiation" patented technology
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Transcription Initiation. Transcription initiation is a stepwise process including (1) promoter binding, (2) promoter melting, (3) promoter release (preceded by 9nt RNA synthesis), and (4) RNA extension of initial transcripts (up to 14nts) to allow the formation of stable elongation complex.
Oligonucleotide modulation of cell adhesion
InactiveUS6015894AHigh expressionAvoid inhibitionBiocidePeptide/protein ingredientsDiseaseTranscription initiation site
Compositions and methods are provided for the treatment and diagnosis of diseases amenable to treatment through modulation of the synthesis or metabolism of intercellular adhesion molecules. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial leukocyte adhesion molecule-1. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a transcription initiation site, a translation initiation site, 5'-untranslated sequences, 3'-untranslated sequences, and intervening sequences. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating cell adhesion proteins with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to one of the foregoing proteins are disclosed. Methods for treatment of diseases responding to modulation cell adhesion molecules are disclosed.
Owner:IONIS PHARMA INC
Processes and vectors for producing transgenic plants
InactiveUS20040221330A1Increase opportunitiesEasy to processSugar derivativesStable introduction of DNAGMO PlantsTranscription initiation
A process for producing transgenic plants or plant cells capable of expressing a coding sequence of interest under transcriptional and translational control of host nuclear transcriptional and translational elements is described by introducing into the nuclear genome of host plants or plant cells a vector comprising said coding sequence of interest which is devoid of (a) an upstream element of initiation of transcription functional in the host plants or plant cells and operably linked to said coding sequence of interest and required for its transcription; (b) an upstream element of initiation of translation functional in the host plants or plant cells and operably linked to said coding sequence of interest; and subsequently selecting plant cells or plants expressing said coding sequence of interest.
Owner:ICON GENETICS
In vivo assembly of transcription units
ActiveUS8609934B2Good choiceOther foreign material introduction processesFermentationBiological bodyTranscription initiation
Owner:MONSANTO TECH LLC
Hepatocellular carcinoma specific promoter and uses thereof
Liver cancer, particularly hepatocellular carcinoma specific promoter sequences and adenovirus vehicles are provided. By providing for transcriptional initiating regulation dependent upon transcription factors that are only active in specific, limited cell types, virus replication will be restricted to the target cells. The modified adenovirus may be used as a vehicle for introducing new genetic capability, particularly associated with cytotoxicity, for treating neoplasia.
Owner:CELLS GENESYS INC
High-efficiency artificial activating transcription factor dCas9-TV, and coding gene and applications thereof
ActiveCN107722125ATranscriptional activationEliminate the need for cloningHydrolasesAntibody mimetics/scaffoldsMetaboliteBiological activation
The invention relates to a high-efficiency artificial activating transcription factor dCas9-TV, and a coding gene and applications thereof. According to a construction method, the carboxyl terminal ofnuclease inactivated Cas9 protein (dCas9) is connected with a plurality of copies of VP64 and TAL transcription-activating domains so as to obtain a series of novel artificial activating transcription factors, and obtain dCas9-TV with the best transcriptional activation activity via screening. When only one guide RNA (gRNA) is adopted for targeting a specific gene promoter, dCas9-TV is capable ofrealizing high efficiency activating of transcription of endogenous genes of Arabidopis thaliana and paddy rice; when a plurality of gRNA are adopted for targeting a plurality of target genes, dCas0-TV is capable of realizing transcription activation of a plurality of genes. In addition, it is confirmed that dCas9-TV possesses the same high efficiency targeting transcription activation activity in human cells. An in vitro assembled dCas9-TV / gRNA ribonucleoprotein compound can be adopted for transcription activation of Arabidopis thaliana and paddy rice endogenous genes. The high-efficiency artificial activating transcription factor dCas9-TV can be adopted in the fields such as genome genetic screening, metabolite biosynthesis pathway reconstruction, and crop improvement.
Owner:SUN YAT SEN UNIV
Expression elements
ActiveUS20080097088A1High expressionMaximizing expressionVectorsSugar derivativesTranscription initiationGenetic element
The invention relates to genetic elements capable of improving the levels of expression of operably-linked transcription units. In particular, said genetic elements are derived from the 5′ untranslated regions of ribosomal protein genes and may comprise a CpG island. Also provided are vectors and host cells comprising said genetic elements and methods of use to obtain high levels of recombinant gene expression.
Owner:MILLIPORE CORP
Retroelement vector system for amplification and delivery of nucleotide sequences in plants
InactiveUS20050048652A1Alter fatty acidImprove reaction to stressMicrobiological testing/measurementOther foreign material introduction processesForeign matterPlant cell
A novel mini-retrotransposon vector system is provided for integrating foreign DNA into plants. The invention includes a novel vector comprising a truncated and modified retroelement which includes the 5′ and 3′ LTR regions that provide transcription initiation and termination sites as well as the cis acting sequences required for reverse transcription. Novel vectors, plant cells, and methods of using the same are disclosed.
Owner:IOWA STATE UNIV RES FOUND
Tumor-specific promoter
InactiveUS20060099188A1High tumor-specificity and promoter activityHigh promoter activityBiocideGenetic material ingredientsPromoter activityC erbb 2
A DNA comprising a 609 bp base sequence from −559 to +50 when the first base sequence of exon 1 of the midkine gene, a human retinoic acid-responsive growth / differentiation factor was set as +1, or a DNA comprising a 251 bp base sequence from −213 to +38 when the transcription initiation point of the c-erbB-2 gene belonging to the EGF receptor family and having a tyrosine kinase activity was set as +1 has a tumor-specific transcription activity, and the promoter activity thereof is high, and therefore is very important as a tumor-specific promoter for use in the suicide gene therapy that combines the use of a gene for a drug metabolizing enzyme and a prodrug for cancer therapy, the gene therapy of cancer using an expression vector that contains a gene encoding a cytokine, and the gene therapy of cancer using an oncolytic virus.
Owner:PRIMMUNE CORP +1
Oligonucleotide inhibition of cell adhesion
Compositions and methods are provided for the treatment and diagnosis of diseases amenable to treatment through modulation of the synthesis or metabolism of intercellular adhesion molecules. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial leukocyte adhesion molecule-1. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a transcription initiation site, a translation initiation site, 5'-untranslated sequences, 3'-untranslated sequences, and intervening sequences. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating cell adhesion proteins with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to one of the foregoing proteins are disclosed. Methods for treatment of diseases responding to inhibition of cell adhesion molecules are disclosed.
Owner:IONIS PHARMA INC
Hepatocellular carcinoma specific promoter and uses thereof
Liver cancer, particularly hepatocellular carcinoma specific promoter sequences and adenovirus vehicles are provided. By providing for transcriptional initiating regulation dependent upon transcription factors that are only active in specific, limited cell types, virus replication will be restricted to the target cells. The modified adenovirus may be used as a vehicle for introducing new genetic capability, particularly associated with cytotoxicity, for treating neoplasia.
Owner:CELLS GENESYS INC
Gene promoter originated from cotton and its application
InactiveCN1869233AFermentationVector-based foreign material introductionNicotiana tabacumAgricultural science
The invention discloses a plant gene promoter and the application. It is has one nucleotide sequence from: the DNA sequence in SEQ ID No: 1; nucleotide sequence of DNA sequence intercross limited in SEQ ID No: 1; the nucleotide sequence has transcription initiation function and has 90% homology of the nucleotide sequence limited by SEQ ID No: 1. The tobacco transgene examination proves theat pGhGlcat1 could endue report gene having high level expression in epidermal hair, top meristem region and androecium and gynoecia of plant flower apparatus. It could be used to improve the plant quality and the gene engineer of fastness.
Owner:TSINGHUA UNIV
DNA (Deoxyribonucleic Acid) methylation marker for evaluating early abortion risk, primer and application thereof
ActiveCN108315410AEasy to detectQuantitatively accurateMicrobiological testing/measurementDNA/RNA fragmentationTranscription initiationPRDM1
The invention belongs to the field of the genetic engineering, and particularly provides a blood DNA (Deoxyribonucleic Acid) methylation marker for evaluating an early abortion risk, a primer and theapplication thereof. The DNA methylation marker comprises eight DNA methylation sites positioned near a PRDM1 gene transcription starting area: cg25608130, cg19577529, cg10573915, cg11072009, cg02667677, cg23778363, cg24793124 and cg07331652. The successful development of the category of the differentiated DNA methylation biological marker is the overturn of a traditional biomarker which gives a priority to protein, a brand new situation is started for diagnosing, preventing and curing the early abortion, and a reference is provided for researching the biomarkers of other diseases. The DNA methylation marker has the advantages of abundant raw materials and convenience in operation and is the biomarker with prospect.
Owner:NANJING MEDICAL UNIV
Populus deltoidesx populus nigra PdMYB2 gene and application thereof
The invention discloses a populus deltoidesx populus nigra resistance-related gene PdMYB2 which plays an important role in the plant salt resistance and drought resistance process. The provided bZIP gene is named as PdMYB2, and the gene has a base sequence shown in SEQ ID NO:3 of a sequence table. When the resistance-related gene PdMYB2 is constructed to an expression vector pCAMBIA1304, a promoter is added in front of a transcription initiation nucleotide, a selective marker GFP is added to authenticate and screen transgenosis vegetable cells or plants, and the expression vector carrying the resistance-related gene PdMYB2 can convert plant hosts through multiple methods and is used for cultivating salt-resistant and drought-resistant plant varieties. The gene has wide application prospects in cultivation of salt-resistance and drought-resistant plants.
Owner:DALIAN NATIONALITIES UNIVERSITY
Higher order structure and binding of peptide nucleic acids
InactiveUS6770738B1Easy to identifyStable strand displacementBiocidePeptide/protein ingredientsTranscription initiationProtein activity
Peptide nucleic acids and analogues of peptide nucleic acids are used to form duplex, triplex, and other structures with nucleic acids and to modify nucleic acids. The peptide nucleic acids and analogues thereof also are used to modulate protein activity through, for example, transcription arrest, transcription initiation, and site specific cleavage of nucleic acids.
Owner:IONIS PHARMA INC +1
Genes coding for tomato beta-galactosidase polypeptides
A novel beta -galactosidase gene family and DNA sequences derived from the cloning of cDNAs encoding products of these genes are provided, as exemplified by a beta -galactosidase II protein which is encoded by a cDNA clone, pZBG2-1-4. A method for modifying cell wall metabolism which involves modifying the activity of at least one beta -galactosidase, and thus modifying the quality of the fruit is also provided. Also provided by the present invention is a DNA construct including some or all of a beta -galactosidase DNA sequence under control of a transcriptional initiation region operative in plants, so that the construct can generate RNA and, optionally, beta -galactosidase polypeptide in plant cells. The present invention also relates to recombinant vectors, which include the isolated nucleic acid molecules of the present invention, and to host cells containing the recombinant vectors, as well as to methods of making such vectors and host cells and for using them for production of beta -galactosidase polypeptides or peptides by recombinant techniques. The present invention also provides plant cells containing DNA constructs of the present invention; plants derived therefrom having modified beta -galactosidase gene expression; and seeds produced from such plants.
Owner:US SEC AGRI
Paramyxoviruses comprising modified transcription start sequence
InactiveUS7144579B2Reduced expression levelLow cytotoxicitySsRNA viruses negative-senseSugar derivativesTranscription initiationGene type
The present invention provides virus vectors of the family Paramyxoviridae in which the transcription start (S) sequence has been modified so as to modify the expression of genes located downstream thereof, a method for producing the vectors, and uses thereof. By measuring the transcription initiation efficiency of the S sequence of each gene carried by Sendai viruses (SeV), it was clarified that the S sequence of F gene has a significantly lower ability to promote transcription than the other three S sequences. When the S sequence of the F gene of wild type Sendai virus was substituted by the S sequence of the P / M / HN gene-type showing a high transcription initiation efficiency, the F gene of the resultant Sendai virus mutant and genes located downstream thereof show elevated expression levels. It was also revealed that this mutant proliferates more quickly than the wild type. The vectors of this invention are useful in elevating the expression of foreign genes and producing pharmaceutical compositions and vaccines. Furthermore, by lowering virus gene expression from virus vectors, it is possible to suppress transcription and / or replication and reduce cytotoxicity of the vector genome.
Owner:DNAVEC RES
RASSF1A gene methylation state detection kit and application thereof
PendingCN110283913AImprove detection efficiencyPrevent non-specificMicrobiological testing/measurementTranscription initiationWilms' tumor
The invention relates to an RASSF1A gene methylation state detection kit. The kit comprises a stem-loop primer, and the stem-loop primer is used for performing specific amplification detection on CpG island-rich sequences in the upstream -1bp to -187bp of the transcriptional initiation region of an RASSF1A gene. The stem-loop primer designed by the invention can significantly improve the detection efficiency of methylated DNA in DNA and prevent non-specific amplification of an unmethylated DNA template; and the kit improves the sensitivity of detection while the specificity of tumor detection is improved.
Owner:广东辉锦创兴生物医学科技有限公司
Genes coding for tomato beta-galactosidase polypeptides
Owner:UNITED STATES OF AMERICA AS REPRESENTED BY THE SEC OF AGRI THE
Short exogenous promoter for high level expression in fungi
InactiveUS20160160299A1Save amountInhibit homologous recombinationSugar derivativesMicroorganismsTranscription initiationHigh level expression
Provided herein are short exogenous fungi transcription promoter nucleic acid sequences and methods of using the exogenous fungi transcription promoter nucleic acid sequences to modulate transcription initiation or rate of transcription.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST
Tumor-specific promoters
InactiveUS20030157065A1High tumor-specificityHigh promoter activityBiocideGenetic material ingredientsPromoter activityC erbb 2
A DNA comprising a 609 bp base sequence from -559 to +50 when the first base sequence of exon 1 of the midkine gene, a human retinoic acid-responsive growth / differentiation factor was set as +1, or a DNA comprising a 251 bp base sequence from -213 to +38 when the transcription initiation point of the c-erbB-2 gene belonging to the EGF receptor family and having a tyrosine kinase activity was set as +1 has a tumor-specific transcription activity, and the promoter activity thereof is high, and therefore is very important as a tumor-specific promoter for use in the suicide gene therapy that combines the use of a gene for a drug metabolizing enzyme and a prodrug for cancer therapy, the gene therapy of cancer using an expression vector that contains a gene encoding a cytokine, and the gene therapy of cancer using an oncolytic virus that exhibits cytotoxic effects only on tumor cells, etc.
Owner:CHIBA PREFECTURE +1
Lilium chalcone synthase genes (chs) promoter as well as preparation method and use thereof
InactiveCN101230347AFermentationVector-based foreign material introductionHot start PCRChalcone synthase
The invention discloses a newly found DNA sequence of the promoter of the chalcone synthase (chs) gene and the manufacturing method and use for the same. The promoter is used for PCR with a joint from sorbonne, and clones 899bp of the upstream regulation sequence of chs gene by combining the characteristics of the nested PCR, TD PCR, hot-started PCR and two-step PCR. The analysis in the promoter database Plant CARE shows that, the sequence has a basically conservative region TACPyAT which expresses specifically in flowers, and has the main cis-acting elements with which the primary promote is provided such as a transcription initiation related TATA box, a transcription auxiliary CAAT box, a G box and CCAAT etc. The promoter can regulate the specific expression of the target gene in the plant, and can provide an effective promoter element for the constructing the plant expression vector, increase the expression of foreign gene, and minimum the biological energy consumption.
Owner:NORTHWEST A & F UNIV
Novel process
Novel organisms, including DNA construct host cell combinations, are disclosed. The organisms comprise a transcription unit (e.g. operon) comprising DNA sequences encoding for enzymes which promote the supply of single carbon units for the conversion of dUMP to dTMP. Examples include: dihydrofolate reductase genes e.g. T4 frd; Serine Hydroxymethyltransferase genes e.g. glyA; 3-phosphoglycerate dehydrogenase genes e.g. serA; and THF synthase genes e.g. ADE3. The organisms are used in a biological method of producing thymidine with significantly reduced levels of uridine.
Owner:GLAXO GROUP LTD
Higher order structure and binding of peptide nucleic acids
InactiveUS20050048552A1Improve thermal stabilityImprove bindingSugar derivativesPeptide/protein ingredientsTranscription initiationProtein activity
Peptide nucleic acids and analogues of peptide nucleic acids are used to form duplex, triplex, and other structures with nucleic acids and to modify nucleic acids. The peptide nucleic acids and analogues thereof also are used to modulate protein activity through, for example, transcription arrest, transcription initiation, and site specific cleavage of nucleic acids.
Owner:IONIS PHARMA INC
Use of aav integration efficiency element for mediating site-specific integration of a transcription unit
InactiveUS20110166207A1Organic active ingredientsGenetic material ingredientsTranscription initiationAdeno associate virus
The invention provides an expression construct comprising a nucleic acid sequence encoding an adeno-associated virus integration efficiency element (AAV IEE), wherein the expression construct is substantially devoid of AAV inverted terminal repeats (AAV ITRs). Such an expression construct site-specifically integrates into a host cell chromosome when provided to a host cell in conjunction with an AAV Rep protein. The invention also provides a method of integrating a nucleic acid sequence of interest into a host cell chromosome through use of such an expression construct, as well as a method of prophylactically or therapeutically treating a mammal for a pathologic state comprising administering to a mammal such an expression construct comprising a nucleic acid sequence encoding a therapeutic factor.
Owner:CORNELL RES FOUNDATION INC
Detection primer, detection kit and detection method of dehiscence resistance of Sesamum indicum
ActiveCN107090516AFast detection methodThe detection method is accurateMicrobiological testing/measurementDNA/RNA fragmentationSesamumMarker-assisted selection
The invention relates to a detection primer, detection kit and detection method of dehiscence resistance of Sesamum indicum, and belongs to the technical field of molecular biology. Compared with the sequence of a dehiscent Sesamum indicum gene, in the KANADI gene of anti-dehiscent Sesamum indicum, 14 bases are deleted in the DNA sequence, 77 bases are deleted in the cDNA sequence, the deleted bases are located between the 1,118th bp and the 1,332th bp in the downstream position of a transcription initiation codon, and the 14 bp bases are located in the connection position of a second exon and a second intron. According to the feature of the gene sequence differences, a detection primer of dehiscence resistance is designed, an important detection primer is provided for molecular marker assisted selection breeding of Sesamum indicum, and a rapid and accurate detection method is provided for screening of a new variety of Sesamum indicum with dehiscence resistance.
Owner:HENAN SESAME RES CENT HENAN ACADEMY OF AGRI SCI
Substances for regulating chromatin histone methylation level of rDNA gene and application thereof
ActiveCN109172597ATrimethylation level decreasedElevated levels of trimethylationOrganic active ingredientsAntineoplastic agentsHistone methylationBiotechnology
The invention discloses substances for regulating expression of PHF6, and provides an application of substances for preparing and regulating the level of rDNA transcription initiation region H3K9me3 in animal cells. The experiments of the present application demonstrate that the level of rDNA transcription initiation region h3k9me3 can be influenced by regulating the expression level of PHF6, andthe overexpression of PHF6 could significantly increase the level of H3K9me3 and reduction of PHF6 can significantly reduce the level of H3K9me3, so as to realize the apparent modification effect on rDNA histone.
Owner:SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
Method for activating gene expression of endogenous Ngn3 and MAFA
ActiveCN109055433AEfficient activationGenetically modified cellsBlood/immune system cellsTranscription initiationEmbryo
The invention discloses a method for activating the gene expression of endogenous Ngn3 and MAFA genes. According to the method disclosed by the invention, the method for activating the expression of the endogenous Ngn3 and / or MAFA genes in targeting cells is established based on an SAM system of CRISPRa (Clustered Regularly Interspaced Short Palindromic Repeats activation). The SAM system comprises sgRNA (small guide Ribonucleic Acid) from upstream -400 to +1bp positions of a transcription starting point of the targeting Ngn3 and / or MAFA genes; a target sequence of the sgRNA aiming the Ngn3 isSEQ ID No. 2 and / or SEQ ID No. 3; a target sequence of the sgRNA aiming the MAFA is SEQ ID No. 6 and / or SEQ ID No. 10. The method is applied to a CRISPRa technology, and Ngn3 and MAFA expression of 293T cells can be efficiently activated through chromatin remodeling. The method disclosed by the invention plays an important role in embryonic development researches of inducing PSCs to be directionally differentiated into beta cells and pancreas through the genes.
Owner:ACADEMY OF MILITARY MEDICAL SCI
Tumor specific promoters of the midkine gene that allow for selective expression in P53-inactivated cells
InactiveUS7030099B2High tumor-specificity and promoter activityHigh promoter activityBiocideSugar derivativesPromoter activityC erbb 2
A DNA comprising a 609 bp base sequence from −559 to +50 when the first base sequence of exon 1 of the midkine gene, a human retinoic acid-responsive growth / differentiation factor was set as +1, or a DNA comprising a 251 bp base sequence from −213 to +38 when the transcription initiation point of the c-erbB-2 gene belonging to the EGF receptor family and having a tyrosine kinase activity was set as +1 has a tumor-specific transcription activity, and the promoter activity thereof is high, and therefore is very important as a tumor-specific promoter for use in the suicide gene therapy that combines the use of a gene for a drug metabolizing enzyme and a prodrug for cancer therapy, the gene therapy of cancer using an expression vector that contains a gene encoding a cytokine, and the gene therapy of cancer using an oncolytic virus.
Owner:CHIBA PREFECTURE +1
Kit for detecting methylation status of Septin 9 genes and application of kit
PendingCN110607369AImprove detection efficiencyAvoid non-specific amplificationMicrobiological testing/measurementTranscription initiationExon
The invention relates to a kit for detecting the methylation status of Septin 9 genes. The kit includes a hairpin-shaped primer, wherein the primer is applied special amplification detection of a CpGisland-rich sequence in an exon 1 of the second transcript NM_001113493.2 of the Septin 9 genes. Through screening and comparison, it is shown that the segment, of a length of 158 bp, in the backwardposition of a transcription initiation point of the second transcript NM_001113493.2 of the Septin 9 genes is a region with the most significant methylation change in the tumor tissue. Through the designed hairpin-shaped primer, the detection efficiency of methylated DNA in DNA can be improved significantly, and non-specific amplification of unmethylated DNA templates is prevented.
Owner:广东辉锦创兴生物医学科技有限公司
Recombinant Microorganism
Provision of a recombinant microorganism which has increased productivity of a protein or polypeptide of interest and a method for producing a protein or polypeptide of interest using the recombinant microorganism. The recombinant microorganism is produced by transferring a gene encoding a protein or polypeptide of interest to a microorganism strain, wherein the microorganism strain is prepared by: introducing a transcription initiation regulatory region that functions in the microorganism or both the transcription initiation regulatory region and a ribosome-binding site that functions in the microorganism into the upstream of a Bacillus subtilis prsA gene or a gene corresponding thereto in the genome of a parental microorganism, or introducing a gene fragment prepared by ligating a transcription initiation regulatory region that functions in the microorganism or both the transcription initiation regulatory region and a ribosome-binding site that functions in the microorganism to the upstream of the Bacillus subtilis prsA gene or a gene corresponding thereto into the genome of a parental microorganism; and deleting or inactivating one or more genes selected from an abrB gene, a dltA gene, a dltB gene, a dltC gene, a dltD gene, a dltE gene, and a gene (genes) corresponding thereto.
Owner:KAO CORP
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