80results about How to "Meet treatment needs" patented technology

The invention provides a drug composition of cabazitaxel and a pharmaceutically acceptable biological carrier and a preparation method thereof. The cabazitaxel drug composition is actually a nanoparticle colloid dispersing system containing cabazitaxel. Cabazitaxel is encapsulated in a polymer shell made of proteins or is associated with the proteins by way of association to form nanoparticles, wherein the mass ratio of the cabazitaxel to the proteins is 1:(8-15); the pH value ranges from 5.0 to 7.0; the average diameter of the particles is not more than 200nm; the Zeta potential ranges from minus 10mv to minus 30mv; and the particles can be subjected to sterile filtration. The composition can be prepared by a high-pressure homogenating method or a protein denaturation and renaturation method. The composition prepared by the invention can be transformed to re-dispersable cakes or powder, can maintain stability for at least 48 hours at 37 DEG C after being re-dispersed in an aqueous medium, and can meet the requirements of intravenous drip therapy.

The invention discloses a lower limb vein thrombosis prevention and treatment instrument and relates to the field of medical instruments. The lower limb vein thrombosis prevention and treatment instrument comprises a lower limb cushion and a massage device. The lower limb cushion comprises a shank cushion plate and a thigh cushion plate which are hinged. The thigh cushion plate is connected with an adjusting rod penetrating through a fixed seat. The massage device comprises a main machine and a leg sleeve. The main machine comprises a box internally provided with an electromagnetic air pump, an electromagnetic water pump, an electronic temperature adjusting device and a constant-temperature water tank. A panel of the box is provided with a time control instrument, a pressure dial gauge, a pressure adjusting valve and a temperature control instrument. The time control instrument, the pressure dial gauge and the pressure adjusting valve are connected with the electromagnetic water pump, and the temperature control instrument is connected with the electronic temperature adjusting device and the electromagnetic water pump. The leg sleeve comprises an air bag communicated with the pressure adjusting valve, and a cushion blanket arranged on the surface layer. The problems that in the prior art, the angle and the height of a lower limb cushion cannot be adjusted, the lower limb is prone to slide down from the two sides, the popliteal space is prone to be pressed, blood circulation is affected, and the cold-proof and heat preservation effect on the affected limb is poor and the problem that the inflation and deflation pressure of a pressure anti- thrombosis pump cannot be adjusted at any time are solved.

The invention relates to liquid-state lipid micro-particles used for delivering a cerebric medicine through a nose olfactory pathway, a preparation method thereof, and a preparation thereof. The liquid-state lipid micro-particles at least comprise a medicine, a lipid material, a penetrating agent, hydroxyethyl starch, propylene glycol and water. The mass ratio of the medicine to the lipid material is 1:1 to 1:10. The volume ratio of propylene glycol to water is 2:1 to 1:10. The liquid-state lipid micro-particles are advantaged in large drug load, high deformation capacity, simple preparation method, and high entrapment rate. The micro-particles are beneficial for the medicine to be delivered into the brain through the nose olfactory pathway and to provide curative effects. The range of appropriate medicines of the liquid-state lipid micro-particles is large, and the liquid-state lipid micro-particles are especially suitable for hormone, polypeptide, gene or vaccine medicines. With the liquid-state lipid micro-particles, preparations such as aerosols, nasal drops, and gels can be produced, such that requirements of cerebric disease medication can be satisfied.

The invention belongs to the technical field of cell culture and particularly discloses a medical automatic cell production device and a production method thereof. The medical automatic cell production device comprises a laminar-flow sterile sealed chamber, in which a sample bottle (such as a blood bottle) is arranged; and a cell separation device for separating samples, a cell rinsing device, a cell induction culture device, a cell proliferation culture device and cell filtering, rinsing and recycling devices for filtering, rinsing and recycling cultured cells are connected through connecting pipes in sequence behind the sample bottle in the sealed chamber. By the invention, the cell separation, the induction culture, the large-scale proliferation culture, cell filtering, rinsing and recycling processes and the like of each patient can be completed in an independent system which is completely sealed and sterile, and therefore the constant conditions of a cell culture environment are ensured, the effector cell proportion is greatly improved, a GMP standard is reached and treatment requirement of patients can be satisfied. In addition, the medical cell production method has high automation degree, simple and convenient operation process, small operation error and high repeatability and can be widely applied to different working environments and occasions, such as medical treatment, biopharming and the like.

The invention discloses a long bone fracture repositioning device, which comprises a proximal end support frame, a distal end support frame, quick drawing extension rods, steel needle fixing clamps and steel needles, wherein the quick drawing extension rods are connected between the proximal end support frame and the distal end support frame, the steel needle fixing clamps are connected to the proximal end support frame and the distal end support frame, the steel needles are clamped by the steel needle fixing clamps, the proximal end support frame and the distal end support frame are same in structure and respectively comprise a transverse chute type repositioning slide plate and two fixed gliding hole plates which are connected to the chute type repositioning slide plate, one surface of each chute type repositioning slide plate is provided with a transverse guide sliding chute, a transverse guide long hole is formed between the bottom of the guide sliding chute and the other surface of the chute type repositioning slide plate, the fixed gliding hole plates are provided with holes for connecting the steel needle fixing clamps, the fixed gliding hole plates are further provided with positioning bulges which are matched with the guide sliding chutes and can slide along the guide sliding chutes. The long bone fracture repositioning device disclosed by the invention is simple in structure, the minimally invasive idea is enhanced, the excellent rate of repositioning is improved, and requirements of fracture repositioning and various malformation correcting can be met to the maximum extent.

The invention discloses cancer diffusion transfer therapeutic equipment which ingrates a targeted function restoration therapy with a therapy chemoradiotherapy and prevents and cures the diffusion transfer of a cancer. The cancer diffusion transfer therapeutic equipment is advanced therapeutic technology integrally formed by a direct current low-medium frequency multifunctional rubbing head, lasers, ultrasonic waves, microwaves, radio frequencies, medicine external application injection intervention in a symmetrically combined mode, and is used for conducting a therapy of function restoration of a diseased region and prevention of diffusion transfer of cancer cells through the symmetrical combination of medicine massage, electrical stimulation, deep layer heating, medicine injection and anti-cancer drugs. According to the 'principle scheme of disease generation and development' in an explanatory memorandum, the cancer diffusion transfer therapeutic equipment aims at the fact that the reasons for generation of cancer diffusion transfer are function degradation and structural pathological changes of system levels of a human body, enables a recovery system level function therapy and a system level structural anti-damage therapy in which the chemoradiotherapy operation is used for killing the cancer cells to be combined in a symmetrical, equivalent, and mutually promoting mode to form an integrated therapeutic method aimed at the reasons, and therefore achieves the targets of controlling and eliminating the cancer diffusion transfer.

The invention relates to a dicalcium silicate compounded self-setting material as well as the preparation method and the application thereof, in particular to a human body hard tissue defect filling and recovery material, and belongs to the field of medical biomaterials. The invention is a paste comprising mixing liquid and dicalcium silicate/calcium sulfate hemihydrate which are mixed with each other at a mass ratio of 0.5-1.5:1, and the mixing liquid is selected from one of deionized water, a simulated body fluid, an inorganic salt solution, or an organic matter solution. Compared with the prior materials, the invention has the characteristics of excellent biological activity, random moulding, self-setting, non-cytoxicity, progressive degradation and adjustable degradation rate, and can achieve the effect of inducing the generation of bone-like apatite. Moreover, the material provided by the invention has better self-setting performance than pure calcium silicon-based or calcium sulfate self-setting bone recovery materials, the preparation method is simple.

The invention discloses a multi-core co-shell compound drug-carrying microsphere, and a preparation method and application thereof. Firstly, through an emulsified solvent evaporation method, an FNS (Finasteride)/PHBV (Poly(3-hydroxybutyrate-3-hydroxyvalerate)) microsphere is prepared, the FNS/PHBV microsphere is coated to a PVA (Polyvinyl alcohol)/CS (Chitosan) hydrophilic polymer matrix through an inverse suspension crosslinking method, a hydrophobic drug is efficiently and artfully coated to the hydrophilic polymer, and the load rate of a hydrophilic drug is improved. The particle size of the prepared FNS/PHBV@PVA/CS drug-carrying microsphere meets the treatment requirement of a prostate targeted embolism. From a drug release curve, a whole drug release process is free from burst release, and sustained release is realized. An in-vitro cell experiment and a hemolytic experiment prove that the microsphere exhibits good cellular compatibility and blood compatibility. A rabbit ear embolism experiment preliminarily indicates that the microsphere has a good embolism effect and good histocompatibility. In addition, the microsphere has the advantages of simple preparation technology andcontrollable particle size and is suitable for industrial batch production. The physical embolism performance and the drug slow release performance of the compound drug-carrying microsphere can be effectively combined, and the microsphere has a potential application prospect in BPH (Benign Prostate Hyperplasia) embolism treatment.

The invention discloses a preparation method for a biodegradable tissue engineering skin stent. The method comprises the following steps: adding carboxylation chitosan and sodium hyaluronate as auxiliary raw materials and adding NaCl as a pore-foaming agent into an aqueous solution of human collagen, stirring till fully dissolving all the added materials, adding glutamine transaminase as a bio-enzyme cross-linking agent for enzymatic cross-linking, and then refrigerating, performing vacuum freeze drying, removing salt and sterilizing by irradiating with Co60, thereby acquiring a degradable three-dimensional tissue engineering skin stent for repairing skin. The skin stent has high biocompatibility and excellent pore structure, is suitable for cell growth and can be used for treating full-thickness defect and scald.

The invention provides pelvic floor muscle training equipment, which comprises a probe, wherein a cylindrical body is arranged in the middle of the probe; a conical head is arranged at the front end of the cylindrical body; a pressure sensor is arranged in the cylindrical body in the middle of the probe; the tail end of the probe is connected to a controller by virtue of a signal line; a control circuit is arranged in the controller; a display screen is arranged on the control panel; and a switch is arranged on the panel of the controller. By virtue of the pelvic floor muscle training equipment disclosed by the invention, a patient can personally operate the step of inserting the training equipment into anus or the patient can operate the step with the assistance of a family member or a medical person, and the patient can personally turn on the switch and observe a training effect; moreover, during training, the patient can directly observe the contraction power of pelvic floor muscle through the display screen, so that the patient is directly supervised virtually; and on the other aspect, the patient, through training, can observe a treatment effect, so that the treatment confidence of the patient is obviously enhanced.

The invention discloses a Chinese patent medicine treating common cold of wind-cold type and the preparation process, which comprises granule, powder, capsule, tablet and medical pill types and is produced by eleven following Chinese herbal medicine material through mixing according to proportion: ephedra, honeysuckle, baikal skullcap root, bupleurum, wild chrysanthemum flower, honeysuckle stem, Chinese rhubarb, prepared rhizome of rehmannia, liquorice root, gardenia and tangerine peel. The Chinese patent medicine has the advantages of dispelling wind and relieving exterior syndrome, clearing heat and toxin, treating cold and obviously improving symptoms such as fever, aversion to coldness, watery nasal discharge, headache, swelling and pain in throat.

The invention relates to mongolian medicine and a preparation method of the medicine. The mongolian medicine is used for treating dyslipidemia, fatty liver and various adiposis as well as hypertension and diabetes caused by the dyslipidemia. The mongolian medicine is basically prepared from the raw materials of the root of red-rooted salvia, fructus piperis longi, sea-buckthorn, Chinese rhubarb and the like by virtue of a scientific processing method, and can be made in to any suitable medicine form, such as powder, liquid, pills, dissolved medicine, tablets, oral liquid or capsules. The mongolian medicine has favorable therapeutic effects to the dyslipidemia, the fatty liver and various adiposis as well as the hypertension and diabetes caused by the dyslipidemia.

The invention relates to the technical field of medical materials, and discloses a hemostatic and osteogenic integrated material and a preparation method and application thereof. The hemostatic and osteogenic integrated material comprises a bioceramic bone glue precursor and a starch gel precursor. The starch gel precursor is added in the preparation process of bioceramics, the bioceramic based hemostatic and osteogenic integrated material is provided, the original impact resistance of starch is strengthened through the semi-crosslinked interpenetrating network formed in the starch gel precursor, and the improvement of the osteogenesis effect is realized by cooperating with biological ceramic bone glue. The hemostatic and osteogenic integrated material has good operability and plasticity, the biodegradability and biocompatibility of the bioceramics and starch can avoid foreign body reaction and stimulate granuloma growth. In addition, other functional drugs or materials can be added in the integrated material according to requirements to meet the needs of various diseases treatment.

The invention discloses isavuconazonium sulfate freeze-dried powder injection and a preparation method and belongs to the technical field of antifungal freeze-dried powder injections. The powder injection contains an effective treating ingredient isavuconazonium sulfate, an excipient mannitol and a pH regulator dilute sulfuric acid. In the preparation process, the mannitol is dissolved with 70-80% water for injection firstly, heat preservation is performed to 0-15 DEG C after all the mannitol is dissolved, the isavuconazonium sulfate is added, pH is regulated to be 1.2-1.8 with the dilute sulfuric acid after stirring and dissolution, the volume is fixed with the water for injection to make the concentration of the isavuconazonium sulfate be 90-130 mg/mL, and then pyrogen removal, aseptic filtration, split charging (the volume is 3-4 mL) and freeze drying are performed to obtain the injection. The prepared isavuconazonium sulfate freeze-dried powder injection is quick to redissolve, complete, good in stability and convenient to store and transport, and the application of the isavuconazonium sulfate in the field of preparations is enriched.

The invention discloses a skin treatment fumigation device for dermatology. The fumigation device comprises a bottom plate, a support frame is arranged on both sides of the upper end of the bottom plate respectively, a horizontal plate is installed at the top ends of the support frames, a fumigation chamber is installed at the middle of the upper end of the horizontal plate, and a driving cylinderis installed in the middle of the left end of the support frame on the right side. A rotating block is mounted at the left end in the driving cylinder, and the left end of the rotating block is in contact with a moving block. The middle portion of the lower end of the moving block is provided with a keyway. The middle portion of the left end of the moving block is provided with a piston shaft, and the left end of the piston shaft is connected with a piston. An air venting chamber is mounted on the outer side of the piston, a fumigator is mounted on the left side of the upper end of the bottomplate, and a storage battery is mounted on the right side of the upper end of the bottom plate. The fumigation device is reasonable in structure and novel in design. By means of matching between therotating block and the moving block, fume in the fumigator can continuously fumigate the skin of a patient through the fumigation chamber, the fumigation efficiency and the fumigation quality are improved, and the treatment demand of the skin patient is met. The fumigation device is simple to operate and high in reliability.

The invention relates to the technical field of medical apparatuses and instruments, in particular to a multiband laser comprehensive therapeutic apparatus. The multiband laser comprehensive therapeutic apparatus comprises a power unit, a voltage conversion unit, a signal control unit, a direction control unit, a constant-current drive unit, a laser output unit and a constant-temperature control unit. The power unit is connected with the voltage conversion unit, the constant-current drive unit, the direction control unit and the constant-temperature control unit. The voltage conversion unit is connected with the signal control unit. The constant-current drive unit is connected with the laser output unit. The signal control unit is connected with the constant-curretn drive unit, the direction control unit and the constant-temperature control unit. At least two laser devices are arranged in the laser output unit. The different laser devices emit lasers with different wavelengths. According to the multiband laser comprehensive therapeutic apparatus, the laser devices can emit the lasers with different wavelengths, and therefore the multiband laser comprehensive therapeutic apparatus can better meet the therapeutic requirements. In addition, the position and the direction of the laser output unit can be regulated according to the requirements, and therefore different affected parts can be conveniently treated.

The invention discloses an air bag support. During use of the air bag support, a medical worker adjusts a connecting plate till the length of the air bag support is up to a length needed by a fixing position of a patient, extrudes an inflatable balloon to expand an air bag so as to effectively fix the fixing position of the patient; meanwhile, the medical worker can accurately control the expansion magnitude of the air bag by checking a pressure meter; at the same time, a universal joint has a multi-direction rotation function, so that after the air bag support is fixed to an arm joint junction of the patient, and the arms of the patient can bend normally. By adopting the air bag support, the fracture position of the patient is fixed effectively through simple operation; the safety of the fixing position of the patient is enhanced through protection of the air bag; meanwhile, the medical worker can adjust the length of the air bag support according to the specific situation of the fixing position of the patient till the air bag support is up to the length needed by the fixing position of the patient, so that the demands of performing treatment on patients according to different illness situations are met.

The invention relates to an ultrasonic wave treating device, which comprises ultrasonic wave detecting treating unit, moving unit and driving unit for driving the detecting treating unit, control unit and image display unit for controlling the detecting treating unit, wherein the detecting treating unit comprises chamber with ultrasonic wave energy converter and ultrasonic wave imager connected to the image display unit; the chamber can be open and closed; when it is open, the ultrasonic wave energy converter expands to two sides of chamber at two sides of ultrasonic wave imager. The invention can avoid image interference between imager and converter, without hurting rectum.

The invention discloses an oval-body-adjustable gynecological close-range back-loading source applicator, and solves the problems that in the prior art, the source applicator cannot adapt to cervicalcancer patients in various vaginal environments, errors of radiotherapy dosage are easily caused, tumor control fails, and side effects are aggravated. The source applicator comprises a middle connecting frame consisting of a connecting frame main body, and is characterized in that in an elbow mounting hole at the upper end of the middle connecting frame, a source applicator bent is inserted; an oval body left hemisphere and an oval body right hemisphere are symmetrically arranged on the two sides of the middle connecting frame respectively and are each composed of a hemispheric shell, and inwards-concave cavities are formed in the opposite sides of the two hemispheric shells respectively. The oval body left hemisphere and the oval body right hemisphere are connected with the middle connecting frame through the oval body adjusting mechanism. The source applicator is reasonable in design, compact in structure, capable of meeting the treatment requirements of different types of middle and advanced cervical cancer radiotherapy patients, easy and convenient to operate, capable of effectively improving the radiotherapy quality, free of trauma, small in side reaction after treatment, economical, practical and good in patient medical compliance.

The invention provides an ultrasonic transducer for an orthopedic surgery instrument. The ultrasonic transducer comprises a detection device, a bearing device and an operation device, wherein the detection device, the bearing device and the operation device are sequentially arranged from bottom to top; the detection device comprises a coupling agent storage box, a probe, an ultrasonic transducer shell and an ultrasonic transducer body; the operation device comprises supporting frames, a handle, an auxiliary soft belt and a motor; the supporting frames comprise the first supporting frame and the second supporting frame, an operation button box and a display screen are arranged on the top of the second supporting frame, and a motor button, a laser lamp button, a transducer power button and a power button are arranged on the operation button box; a power source is arranged in the operation button box, the coupling agent storage box is arranged at the bottom of the detection device, the probe is arranged at the bottom of the coupling agent storage box, and an opening and closing groove is formed in the joint of the probe and the coupling agent storage box. The ultrasonic transducer is reasonable in structure, good in using effect and convenient to use in medical equipment.