Hemostatic and osteogenic integrated material, preparation method and application thereof

A technology of osteogenesis and ceramic materials, which is applied in the field of medical materials, can solve the problems of bone wax without osteogenesis characteristics, and achieve the effects of improving sealing performance, improving osteogenesis effect, good operability and plasticity

Active Publication Date: 2019-09-24
南京纳铠生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Also, bone wax does not have very good osteogenic properties

Method used

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  • Hemostatic and osteogenic integrated material, preparation method and application thereof
  • Hemostatic and osteogenic integrated material, preparation method and application thereof
  • Hemostatic and osteogenic integrated material, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1: Preparation of the integrated material of the present invention and its in vitro hemostatic test

[0040] 1. Preparation method

[0041] A, the preparation of starch gel precursor

[0042] Dissolve calcium nitrate in deionized water at 25% by mass to obtain an electrolyte solution; add cornstarch to the prepared electrolyte solution at 75% by mass, and stir fully at a temperature of 80°C until the starch is completely gelatinization to obtain viscous liquid;

[0043] Place the obtained viscous liquid in a high-temperature drying cabinet overnight until it is completely dry, then beat it into a powdery solid with a pulverizer, and pass through a 60-mesh sieve.

[0044] B. Preparation of Bioceramic Bone Glue Precursor

[0045] Weigh 60% tetracalcium phosphate, 20% pregelatinized starch and 20% hydroxyapatite.

[0046] Mix all three evenly.

[0047] C. Preparation of integrated materials

[0048] The bioceramic bone glue precursor is mixed with the starch ...

Embodiment 2

[0066] Example 2: Preparation of the integrated material of the present invention and its in vitro osteogenesis induction test

[0067] 1. Preparation method

[0068] A, the preparation of starch gel precursor

[0069] Dissolve magnesium chloride in deionized water at 10% by mass to obtain an electrolyte solution; add waxy starch to the prepared electrolyte solution at 90% by mass, and stir fully at a temperature of 80°C until the starch is completely gelatinization to obtain viscous liquid;

[0070] Place the obtained viscous liquid in a high-temperature drying cabinet overnight until it is completely dry, then beat it into a powdery solid with a pulverizer, and pass through a 60-mesh sieve.

[0071] B. Preparation of Bioceramic Bone Glue Precursor

[0072] Weigh 60% tricalcium phosphate, 20% corn starch and 20% bioactive glass.

[0073] Mix all three evenly.

[0074] C. Preparation of integrated materials

[0075] The bioceramic bone glue precursor is mixed with the st...

Embodiment 3

[0097] Example 3: Preparation of the integrated material of the present invention and its hemostasis and osteogenesis test in mice

[0098] 1. Preparation method

[0099] A, the preparation of starch gel precursor

[0100]According to 12.5% ​​by mass percentage, calcium chloride is dissolved in deionized water to obtain an electrolyte solution; according to 87.5% by mass percentage, potato starch is added to the prepared electrolyte solution, and the temperature is 80°C and fully stirred until the starch Completely gelatinized to obtain viscous liquid;

[0101] Place the obtained viscous liquid in a high-temperature drying cabinet overnight until it is completely dry, then beat it into a powdery solid with a pulverizer, and pass through a 60-mesh sieve.

[0102] B. Preparation of Bioceramic Bone Glue Precursor

[0103] Weigh 80% tricalcium silicate and 20% pregelatinized starch.

[0104] Mix the two evenly.

[0105] C. Preparation of integrated materials

[0106] The bio...

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Abstract

The invention relates to the technical field of medical materials, and discloses a hemostatic and osteogenic integrated material and a preparation method and application thereof. The hemostatic and osteogenic integrated material comprises a bioceramic bone glue precursor and a starch gel precursor. The starch gel precursor is added in the preparation process of bioceramics, the bioceramic based hemostatic and osteogenic integrated material is provided, the original impact resistance of starch is strengthened through the semi-crosslinked interpenetrating network formed in the starch gel precursor, and the improvement of the osteogenesis effect is realized by cooperating with biological ceramic bone glue. The hemostatic and osteogenic integrated material has good operability and plasticity, the biodegradability and biocompatibility of the bioceramics and starch can avoid foreign body reaction and stimulate granuloma growth. In addition, other functional drugs or materials can be added in the integrated material according to requirements to meet the needs of various diseases treatment.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a hemostatic and osteogenic integrated material, a preparation method and application thereof. Background technique [0002] Orthopedic surgery is a discipline based on surgical treatment. Bleeding is a dangerous complication in the process of surgical treatment. Excessive blood loss during surgery can lead to unstable vital signs, even hemorrhagic shock or compressive hematoma, which is extremely detrimental to the recovery of the patient's prognosis; on the other hand, A large amount of intraoperative blood loss affects the clarity of the surgical field of view, which is not conducive to the development of the surgical process. With the development of hemostatic devices and new hemostatic materials, intraoperative hemostasis control measures have become more mature and perfect. However, due to special circumstances such as bone marrow oozing, adjacent nerve sheath b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00A61L24/02A61L24/08A61L27/02A61L27/10A61L27/20A61L27/50A61L27/52A61L27/54
CPCA61L24/0031A61L24/02A61L24/08A61L27/025A61L27/10A61L27/20A61L27/50A61L27/52A61L27/54A61L2400/04A61L2430/02C08L3/02
Inventor 葛隽杨世童徐文
Owner 南京纳铠生物医药科技有限公司
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