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Composite self-curing material of dicalcium silicate, preparation and uses thereof

A self-curing technology of dicalcium silicate, which is applied to human hard tissue defect filling and repairing materials. It will be used in the field of dicalcium silicate for a long time, and can solve the problems of lack of biological activity, lack of long-term structural support, and no promotion of bone regeneration. , to achieve the effects of excellent biocompatibility, excellent biological performance and excellent biological activity

Inactive Publication Date: 2009-05-13
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some defects in the application of this material, which are mainly reflected in the following aspects: First, although this material solidifies quickly and can provide structural support for the defect site in a short time, the bone cement paste can Poor injectability and lack of ability to provide long-term structural support to the repair site; secondly, although this material has good biocompatibility and osteoconductivity, it is not bioactive and does not promote bone regeneration
Third, clinical studies have shown that this material degrades too quickly in the body, which easily leads to a large amount of fluid leakage from the repair site, and a large amount of SO released during the degradation process 4 2- , in addition, this material also has the problem of metabolism

Method used

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  • Composite self-curing material of dicalcium silicate, preparation and uses thereof
  • Composite self-curing material of dicalcium silicate, preparation and uses thereof
  • Composite self-curing material of dicalcium silicate, preparation and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 1) Blending liquid preparation

[0044] Weigh 1.0 g of analytically pure sodium bicarbonate and dissolve it in 99.0 mL of deionized water to obtain a 1.0 wt.% sodium bicarbonate solution, sterilize, seal it in a sterile bottle, and set aside.

[0045] 2) Preparation of dicalcium silicate / calcium sulfate hemihydrate composite self-curing material:

[0046] The dicalcium silicate / calcium sulfate hemihydrate composite material powder with a calcium sulfate hemihydrate content of 30wt.% and the blending solution are fully blended for 0.5-1 minute at a ratio of liquid to solid mass ratio of 1.2:1 to obtain micro Dicalcium silicate / calcium sulfate hemihydrate composite self-curing material for invasive treatment. The self-curing material can reach the initial setting in about 20 minutes after being injected into the defect site, the self-curing material slurry can be injected within 15 minutes, the compressive strength of the self-curing material can reach 9.6∽36.0MPa, and t...

Embodiment 2

[0048] 1) Blending liquid preparation

[0049] Weigh 1.0 g of analytically pure sodium bicarbonate and dissolve it in 99.0 mL of deionized water to obtain a 1.0 wt.% sodium bicarbonate solution, sterilize, seal it in a sterile bottle, and set aside.

[0050] 2) Preparation of dicalcium silicate / calcium sulfate hemihydrate composite bone defect filling material:

[0051] The dicalcium silicate / calcium sulfate hemihydrate composite material powder with a calcium sulfate hemihydrate content of 60wt.% and the blending solution are fully blended at a liquid-solid mass ratio of 1.2:1, and injected into the mold for 0.5-1 minute. ℃ and 100% humidity conditions for curing for more than 7 days, after which the dicalcium silicate / calcium sulfate hemihydrate composite material pellets or small discs (C 2 S / plaster Pellets). The compressive strength of the pellets or discs can reach 7.0∽9.0MPa, and the degradation rate can reach more than 80% after 21 days, and has good biological activ...

Embodiment 3

[0053] 1) Preparation of blending solution

[0054] The simulated body fluid is used as the blending solution, and the ion concentration of the simulated body fluid is shown in Table 2 (pH=7.25-7.4):

[0055] Table 2

[0056] Ion species Na + K + Mg 2+ Ca 2+ Cl - HCO 3 - HPO 4 2- ion concentration

(mmol / L) 142.0 5.0 1.5 2.5 148.8 4.2 1.0

[0057] 2) Preparation of Dicalcium Silicate / Calcium Sulfate Hemihydrate Composite Degradable Material

[0058] Fully blend the dicalcium silicate / calcium sulfate hemihydrate composite material powder with a calcium sulfate hemihydrate content of 5-95wt.% and the blending solution at a ratio of 0.8-1.2:1 by liquid-solid mass ratio for 0.5-1 minute, inject The mold was cured for more than 7 days at 37°C and 100% humidity, and then the dicalcium silicate / calcium sulfate hemihydrate composite material pellets (C 2 S / plaster Pellets). The compressive strength of the pellets can reach 7.3∽37....

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Abstract

The invention relates to a dicalcium silicate compounded self-setting material as well as the preparation method and the application thereof, in particular to a human body hard tissue defect filling and recovery material, and belongs to the field of medical biomaterials. The invention is a paste comprising mixing liquid and dicalcium silicate / calcium sulfate hemihydrate which are mixed with each other at a mass ratio of 0.5-1.5:1, and the mixing liquid is selected from one of deionized water, a simulated body fluid, an inorganic salt solution, or an organic matter solution. Compared with the prior materials, the invention has the characteristics of excellent biological activity, random moulding, self-setting, non-cytoxicity, progressive degradation and adjustable degradation rate, and can achieve the effect of inducing the generation of bone-like apatite. Moreover, the material provided by the invention has better self-setting performance than pure calcium silicon-based or calcium sulfate self-setting bone recovery materials, the preparation method is simple.

Description

[0001] field of invention [0002] The invention relates to a dicalcium silicate composite self-curing material and a preparation method and application thereof, relates to a human body hard tissue defect filling and repairing material, and belongs to the field of medical biomaterials. Background technique [0003] In the restoration of human bone tissue and tooth defects, calcium phosphate bone cement can be used to fill and repair the defect. At present, with the help of minimally invasive treatment, people design the filling material into a paste that can be injected and self-cured in the body for injection treatment, which not only avoids the complicated process of traditional surgery, reduces the pain of patients, but also greatly reduces the Treatment costs. [0004] Since Chow et al. proposed the concept of calcium phosphate bone cement (CPC) in the 1980s (Chow et al., JDent Res 1984; 63:200), many scholars have successively developed a series of CPC bone cements with...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/02A61K6/027
Inventor 常江郇志广
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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