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Tumor chemotherapeutic medicinal preparation and preparation method thereof

A chemotherapeutic drug, chemotherapeutic drug technology, applied in the directions of antitumor drugs, drug combination, drug delivery, etc., can solve the problems of increasing the toxic and side effects of nano-carrier chemotherapeutic drugs on the body, the toxic and side effects of biological organisms, and unfavorable clinical promotion and application. The effect of exerting drug efficacy, reducing drug resistance, and improving drug efficacy

Active Publication Date: 2012-01-04
HUBEI SOUNDNY BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since nanomaterials are exogenous substances, they have certain toxic and side effects on biological organisms. At the same time, the particle size specifications of clinically used nanoparticles also make it easy to pass through the cell membrane of normal cells, which increases the number of nanocarriers and all of them. Toxic and side effects of chemotherapy drugs carried on the body
In addition, the special materials and process technology used in some nanoparticles greatly increase the cost, which is not conducive to clinical application

Method used

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  • Tumor chemotherapeutic medicinal preparation and preparation method thereof
  • Tumor chemotherapeutic medicinal preparation and preparation method thereof
  • Tumor chemotherapeutic medicinal preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1: Using chemotherapeutic drugs to induce apoptosis of mouse liver cancer cells and human ovarian cancer cells to produce microparticles (formation of cell vesicles encapsulating chemotherapeutic drugs)

[0045] 1. Experimental materials and reagents

[0046] H22 mouse liver cancer cells, A2780 human ovarian cancer cells, and doxorubicin (commercially available, a commonly used chemotherapy drug in clinical practice, with red fluorescence).

[0047] 2. Experimental steps

[0048] 1) Cultivate H22 mouse liver cancer cells in DMEM cell culture medium to make the cell amount reach 2×10 7 ;Cultivate A2780 human ovarian cancer cells to make the cell volume reach 2×10 7 Divide the above-mentioned H22 mouse liver cancer cell culture medium into two groups, each group including half of the amount of H22 mouse liver cancer cells; similarly divide the A2780 human ovarian cancer cell culture medium into two groups, each group including half of the amount of A2780 human o...

Embodiment 2

[0054] Example 2: Using ultraviolet rays to induce apoptosis of mouse liver cancer cells and human ovarian cancer cells to produce cell vesicles and incubate with chemotherapeutic drugs to obtain microparticles coated with chemotherapeutic drugs

[0055] 1. Experimental Materials and Reagents

[0056] The H22 mouse liver cancer cells and A2780 human ovarian cancer cells used were the same as in Example 1, the ultraviolet device was owned by a conventional cell clean bench, and the doxorubicin was the same as in Example 1.

[0057] 2. Experimental steps

[0058] 1) Culture H22 mouse liver cancer cells and A2780 human ovarian cancer cells to make the cell volume reach 2×10 7 , the culture method is the same as in Example 1, the above-mentioned H22 mouse liver cancer cell culture solution is divided into two groups, each group includes half of the amount of H22 mouse liver cancer cells, and the A2780 human ovarian cancer cell culture solution is also divided into two groups, eac...

Embodiment 3

[0064] Example 3: Ultraviolet-induced cell vesicles produced by mouse liver cancer cell lines can be taken up by mouse liver cancer cells

[0065] 1. Experimental materials and reagents

[0066] The H22 mouse liver cancer cells and the ultraviolet device used were the same as in Example 1, carboxyfluorescein succinimidyl ester (CFSE) (green fluorescent dye, commercially available), PKH26 (red fluorescent dye, commercially available).

[0067] 2. Experimental steps

[0068] 1) Culture 2×10 7 Individual H22 mouse liver cancer cells were cultured in the same manner as in Example 1, and the cultured H22 mouse liver cancer cells were divided into two groups with the same amount.

[0069] 2) For the first group of cells, the green fluorescent dye CFSE was used to label according to a conventional method.

[0070] For the second group of cells, the red fluorescent dye PKH26 was used to label according to the conventional method, and the labeled H22 mouse liver cancer cells showed ...

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Abstract

The invention provides a tumor chemotherapeutic medicinal preparation and a preparation method thereof. The tumor chemotherapeutic medicinal preparation comprises a cell vesicle derived from apoptotic tumor cells and a chemotherapeutic medicine which is wrapped in the cell vesicle and serves as an active ingredient. The chemotherapeutic medicine in the medicinal preparation comprises an active ingredient for treating tumor which provides the cell vesicle. The invention also provides a preparation method for the tumor chemotherapeutic medicinal preparation. By the technical scheme provided by the invention, the chemotherapeutic medicine can be selectively released at the tumor site, so that the chemotherapeutic medicine can exert medicine effect continuously, the killing effect of the chemotherapeutic medicine on the tumor cells can be improved, and the toxic or side effect of the chemotherapeutic medicine on the normal cells can be reduced.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to a tumor chemotherapy drug preparation and a preparation method thereof. Background technique [0002] In recent years, as a disease that seriously threatens people's lives, tumors have become a topic of research for many scientific researchers. Among them, the use of chemical drugs (chemotherapy drugs) to eliminate tumor cells is a key step in the treatment of tumors. This is a very important and conventional method. However, while using chemotherapy drugs to destroy tumor cells, it will also kill normal tissue cells, which not only brings unbearable toxic side effects to patients, but also often leads to chemotherapy failure. [0003] The essence of the toxic and side effects of chemotherapy drugs is the killing of normal cells of the body by chemotherapy drugs. In order to avoid non-specific killing of normal cells by chemotherapeutic drugs, the ...

Claims

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Application Information

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IPC IPC(8): A61K47/46A61K45/00A61P35/00A61P35/02A61K33/243
CPCA61K45/06A61K9/127A61K35/13A61K9/5089A61K9/5068A61K33/24A61K9/0019A61K31/704A61K31/519A61P35/00A61P35/02A61K33/243A61K2300/00
Inventor 黄波
Owner HUBEI SOUNDNY BIOLOGICAL TECH
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